Pulmonary and Systemic Inflammation
In order to begin work on a disease, with the aim to ameliorate human suffering, a researcher must first educate herself about the nitty-gritties of what is involved and what is at stake. This involves recreating the inner workings of a human disease in a nonhuman but closely related animal so as to facilitate delineation of each and every fine detail of the onset, etiology, establishment, development, progression, and exacerbations (cyclical manifestations in an exaggerated form of the disease pathology). In order to understand these inner workings, the model has to be simple enough and yet similar enough to be of any use to alleviate suffering of the human patients. The bench-to-bedside strategy therefore aims to recreate a complex disease first, part by part, outside the body (ex vivo) which enables easy dissection of nodal points of disease onset-progression, and then the entire composite disease phenotype is addressed using a whole organism by various treatments such as administration of a molecule (chemically induced), be it a drug, a polymer, an antibody or a peptide, or even an allergen or toxin, by various routes of administration, which, over various time intervals, usually manifest in a complex human disease in the subhuman primate or non-primate.
KeywordsChronic Obstructive Pulmonary Disease Airway Hyperresponsiveness Chronic Obstructive Pulmonary Disease Exacerbation Airway Remodel Complex Human Disease
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