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Implication of Endophytic Metabolite and Their Derivatives in Cancer Chemotherapy: A Prospective Study

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Advances in Endophytic Research

Abstract

Incidence of cancer keep increasing worldwide may be due to genetic aberration, environmental effect, diet, socioeconomic factors, and various types of infections. Our previous studies revealed an association of Helicobacter pylori (H. pylori) and their species, Salmonella Typhi (S. Typhi), and Mycobacterium with various gastrointestinal tract (GI) cancers including oral, oropharyngeal, esophageal, gastric, gallbladder, pancreatic, and anal-canal cancers. We experience that poor cure rate is reported due to failure of conventional medicine, drug resistance, and failure to know the exact cause. As we are a group of oncologist and basic researcher, it is our experience that surgical procedures and chemotherapy are better adjuvant therapeutic option for cancer treatment. The area of chemotherapy is enhanced, but basic foundation is devised from natural products, which are used directly or as synthetic derivatives as stand-alone or in different combinations. Microorganisms, either bacteria or fungi that live inside plant tissue (endophytes) system, are big source of natural antimicrobial compound. It is known that endophytic alkaloids, taxoids, podophyllotoxins, etc., have an antineoplastic activity. Keeping these facts in mind, this chapter points out the active exploration and implication of endophytic metabolite and their derivatives in cancer chemotherapy in near future. Obtained data were analyzed and result showed that the endophytic metabolites may be potential source of newer cancer chemotherapeutic drugs. It concluded that in the field of cancer chemotherapy, search for novel drugs from endophytic origin is still a priority.

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Acknowledgements

The authors are thankful to Dr. V. C. Verma (Postdoctoral Fellow) and Prof. Gopal Nath (Head), Department of Microbiology, Banaras Hindu University, Varanasi, for his encouragement to write about such newer aspects of medical and basic science. Financial assistance from the Council of Scientific and Industrial Research, New Delhi, India (file no. 9/13(306)/2010-EMR-I), as Research associateship to RRM is gratefully acknowledged for the years 2010–2013.

Dedication

This article is dedicated to late Er. Shivendra Ranjan Mishra (1982–2012), younger brother of Raghvendra Raman Mishra, who lost his life in an accident of explosion in piped natural gas (PNG) at Kanpur, Uttar Pradesh, India.

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Authors and Affiliations

  1. Ranjan Physiology and Biochemistry Laboratory, Department of Botany, Centre of Food Technology, University of Allahabad, Allahabad, 211002, India

    Pragya Mishra

  2. Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India

    Raghvendra Raman Mishra

  3. Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India

    Mallika Tiwari & Hari S. Shukla

  4. Department of Pharmaceutical Sciences, Faculty of Health Science, Sam Higginbottom Institute of Agriculture Technology and Sciences – Deemed University, Allahabad, India

    Parjanya Shukla

  5. Department of Botany, Faculty of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Archana Singh

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  1. Pragya Mishra
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  2. Raghvendra Raman Mishra
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  4. Parjanya Shukla
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  6. Hari S. Shukla
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Correspondence to Hari S. Shukla .

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Editors and Affiliations

  1. Centre of Experimental Medicine and Surgery (CEMS), Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Vijay C. Verma

  2. School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, United Kingdom

    Alan C. Gange

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Mishra, P., Mishra, R.R., Tiwari, M., Shukla, P., Singh, A., Shukla, H.S. (2014). Implication of Endophytic Metabolite and Their Derivatives in Cancer Chemotherapy: A Prospective Study. In: Verma, V., Gange, A. (eds) Advances in Endophytic Research. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1575-2_19

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