In recent years edible vaccine emerged as a new concept developed by biotechnologists. Edible vaccines are subunit vaccines where the selected genes are introduced into the plants and the transgenic plant is then induced to manufacture the encoded protein. Foods under such application include potato, banana, lettuce, corn, soybean, rice, and legumes. They are easy to administer, easy to store and readily acceptable delivery system for different age group patients yet cost effective. Edible vaccines present exciting possibilities for significantly reducing various diseases such as measles, hepatitis B, cholera, diarrhea, etc., mainly in developing countries. However, various technical and regulatory challenges need to overcome in the path of this emerging vaccine technology to make edible vaccine more efficient and applicable. This chapter attempts to discuss key aspects of edible vaccines like host plants, production, mechanism of action, advantages and limitations, applications, and different regulatory issues concerned to edible vaccines.
Human Immunodeficiency Virus Transgenic Plant Human Papilloma Virus Newcastle Disease Virus Rabies Virus
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Arntzen CJ (1997) Edible vaccines. Public Health Rep 112(3):190–197Google Scholar
Chowdhury K, Bagasra O (2007) An edible vaccine for malaria using transgenic tomatoes of varying sizes, shapes and colors to carry different antigens. Med Hypo 68:22–30CrossRefGoogle Scholar
Das DK (2009) Plant derived edible vaccines. Curr Tren Biotech Pharm 3(2):113–127Google Scholar
Eibl C, Zou Z, Beck A, Kim M, Mullet J, Koop HU (1999) In vivo analysis of plastid psbA, rbcL and rpl32 UTR elements by chloroplast transformation: tobacco plastid gene expression is controlled by modulation of transcript levels and translation efficiency. Plant J 19:333–345PubMedCrossRefGoogle Scholar
Gruissem W, Tonkyn J (1993) Control mechanisms of plastid gene expression. CRC Critical Rev Plant Biol 12:19–55Google Scholar
Ma JKC, Hein MB (1995) Immunotherapeutic potential of antibodies produced in plants. Trends Biotechnology 13:522–527CrossRefGoogle Scholar
Ma S, Huang Y, Davis A, Yin Z, Mi Q, Menassa R, Brandle JE, Jevnikar AM (2005) Production of biologically active human interleukin-4 in transgenic tomato and potato. Plant Biotechnol J 3(3):309–318PubMedCrossRefGoogle Scholar
Mor TS, Richter L, Mason HS (1999) Expression of rotavirus proteins in transgenic plants. In: Altman A, Ziv M, Izhar S (eds) Plant biotechnology and in vitro biology in the 21st century. Kluwer Academic publishers, Dordrecht, pp 521–524CrossRefGoogle Scholar
Richter LJ, Thanavala Y, Arntzen CJ, Mason HS (2000) Production of hepatitis B surface antigen in transgenic plants for oral immunization. Nat Biotechnol 18(11):1167–1171PubMedCrossRefGoogle Scholar
Tacket CO, Mason HS, Losonsky G, Estes MK, Levine MM, Arntzen CJ (2000) Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes. J Infect Dis 182:302–305PubMedCrossRefGoogle Scholar
Thanavala Y, Mahoney M, Pal S, Scott A, Richter L, Natarajan N, Goodwin P, Arntzen CJ, Mason HS (2005) Immunogenicity in humans of an edible vaccine for hepatitis B. Proc Natl Acad Sci USA 102:3378–3382PubMedCrossRefGoogle Scholar
Wang L, Goschnick MW, Coppel RL (2004) Oral immunization with a combination of Plasmodium yoelii merozoite surface protein 1 and 4/5 enhances protection against lethal malarial challenge. Infect Immunol 72:6172--6175Google Scholar