Histopathology of Invasive Fungal Rhinosinusitis

  • R. B. Deshpande


Histopathological examination forms the basis of diagnosis, classification, and management of invasive fungal rhinosinusitis [1, 2]. In cases where fungal infection is suspected on clinical grounds, demonstration of fungal elements should be sufficient to start treatment, but histopathological examination is necessary to confirm the diagnosis of “invasive” fungal infection and to properly classify the fungal disease for further management.


Fungal Hypha Multinucleated Giant Cell Invasive Fungal Disease Fungal Element Allergic Fungal Sinusitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    deShazo RD, O’Brien M, Chapin K, et al. A new classification and diagnostic criteria for invasive fungal sinusitis. Arch Otolaryngol Head Neck Surg. 1997;123:1181–8.PubMedCrossRefGoogle Scholar
  2. 2.
    Das A, Bal A, Chakarabarti A, Panda N, Joshi K. Spectrum of fungal rhinosinusitis; a histopathologist’s perspective. Histopathology. 2009;54:854–9.PubMedCrossRefGoogle Scholar
  3. 3.
    Schell WA. Histopathology of fungal rhinosinusitis. Otolaryngol Clin North Am. 2000;33:251–76.PubMedCrossRefGoogle Scholar
  4. 4.
    Barnes L, Peel RL. Head and neck pathology: a text/atlas of differential diagnosis. New York: Igahu-Shoin; 1990. p. 170.Google Scholar
  5. 5.
    Michaels L. Ear, nose and throat histopathology. New York: Springer; 1987. p. 146–8.CrossRefGoogle Scholar
  6. 6.
    Johnson JT. Infections. In: Cummings CW, Krause CJ, editors. Otolaryngology head neck surgery, vol. 2. 2nd ed. St. Louis: Mosby Year Book; 1993. p. 931–3.Google Scholar
  7. 7.
    Myerowitz RL, Guggenheimer J, Barnes L. Infectious diseases of the head and neck. New York: Marcel Dekker; 1985. p. 1784–6.Google Scholar
  8. 8.
    Straatsma BR, Zimmerman LE, Gass JDM. Phycomycosis: a clinicopathologic study of fifty one cases. Lab Invest. 1962;11:963–85.PubMedGoogle Scholar
  9. 9.
    Milro CM, Blanshard JD, Lucas S, Michaels L. Aspergillosis of the nose and paranasal sinuses. J Clin Pathol. 1989;42:123–7.CrossRefGoogle Scholar
  10. 10.
    Veress B, Malik OA, el-Tayeb AA, et al. Further observations on the primary paranasal Aspergillosis granuloma in the Sudan: a morphological study of 46 cases. Am J Trop Med Hyg. 1973;22:765–72.PubMedGoogle Scholar
  11. 11.
    Currens J, Hutcheson PS, Slavin RG, Citardi MJ. Primary paranasal Aspergillus granuloma: a case report and review of literature. Am J Rhinol. 2002;16:165–8.PubMedGoogle Scholar
  12. 12.
    Schubert MS, Goetz DW. Evaluation and treatment of allergic fungal sinusitis. I. Demographics and diagnosis. J Allergy Clin Immunol. 1998;102:387–94.PubMedCrossRefGoogle Scholar
  13. 13.
    Katzenstein AA, Sale SR, Greenburger PA. Allergic Aspergillus sinusitis: a newly recognized form of sinusitis. J Allergy Clin Immunol. 1983;72:89–93.PubMedCrossRefGoogle Scholar
  14. 14.
    Gourley DS, Whisman BA, Jorgensen NL, et al. Allergic Bipolaris sinusitis. Clinical and histopathological characteristics. J Allergy Clin Immunol. 1990;85:583–91.PubMedCrossRefGoogle Scholar
  15. 15.
    Bent III JP, Kuhn FA. Diagnosis of allergic fungal sinusitis. Otolaryngol Head Neck Surg. 1994;111:580–8.PubMedCrossRefGoogle Scholar
  16. 16.
    de Shazo RD, Swain RE. Diagnostic criteria for allergic fungal sinusitis. J Allergy Clin Immunol. 1995;95:24–35.Google Scholar
  17. 17.
    Ferguson BJ. Eosinophilic mucin rhinosinusitis: a distinct clinicopathological entity. Laryngoscope. 2000;110:799–813.PubMedCrossRefGoogle Scholar
  18. 18.
    Ramadan HH, Quraishi HA. Allergic mucin sinusitis without fungus. Am J Rhinol. 1997;11:145–7.PubMedCrossRefGoogle Scholar

Copyright information

© Springer India 2014

Authors and Affiliations

  1. 1.Department of PathologyP.D. Hinduja HospitalMahim, MumbaiIndia

Personalised recommendations