Pharmacogenomics of Allergy and Asthma

  • Anjana Munshi
  • Luciana B. Crotti
  • Vandana Sharma
  • Sanjeev Sharma
  • Luis A. Espinoza


Allergy and asthma are the diseases of multifactorial etiologies increasing dramatically all over the world. Numerous factors (e.g., aeroallergen, toxin, pathogen, food, chemical insect debris, and drugs) play a key role in the pathophysiology of allergy and asthma. Recent advances in the field of genetics have led to the identification of genetic factors which are involved not only in the pathogenesis of asthma and allergy but also significantly (60–70 %) contribute toward the interindividual variability to drug response and adverse drug reactions. There are several common categories of medications for treating asthma and allergy. Significant heterogeneity in the efficacy and adverse drug reactions of anti-allergic and anti-asthmatic drugs have been observed and efforts have been made to study the role of genetic determinants in the variable interindividual response to medication. Armed with the knowledge of a patient’s pharmacogenomic information, a clinician could predict the response to certain drugs and adverse drug reactions to improve the efficacy and tolerability of the therapeutic interventions.


Glucocorticoid Receptor Food Allergy Peak Expiratory Flow Rate Ipratropium Bromide Morning Peak Expiratory Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Diamine oxidase


A disintegrin and metalloproteinase domain-containing protein 33


Beta adrenergic receptors


Beta-2 adrenergic receptor


Adverse Drug Reactions


Arachidonate 5 lipoxygenase


Adenosine triphosphate


Bronchoalveolar lavage fluid


Cyclic adenosine monophosphate


Chemokine (C-C motif) ligand 11


Cluster of differentiation 14 (CD14)


Cystic fibrosis transmembrane conductance regulator


Cholinergic receptor muscarinic 2


Calcium-activated chloride channel regulator 1




Caspase recruitment domain-containing protein 15


Corticotrophin-releasing hormone receptor 1


Cytoplasmic FMR1-interacting protein


Cytochrome P450 family 1 subfamily A, polypeptide 2


Cytochrome P450 family 2 subfamily E, polypeptide 1


Cysteinyl leukotriene receptor


Defensin beta 1


Deoxyribonucleic acid


Dipeptidyl-peptidase 10


Fc epsilon receptor I beta-chain


Food and Drug Administration


FK506-binding protein 51




Trans-acting T-Cell-specific transcription factor


Glucocorticoid resistant


Glucocorticoid sensitive


Granulocyte-macrophage colony-stimulating factor


Granulocyte-monocyte colony-stimulating factor


G protein-coupled receptor for asthma


S-Nitrosoglutathione reductase


Glutathione S-transferase


Genome-wide association study


Histidine decarboxylase


Human glucocorticoid receptor


Human leukocyte antigen


Histamine N-methyl transferase


Histamine receptor


Interferon γ


Interferon gamma receptor-1


Immunoglobulin E






The International Study of Asthma and Allergies in Childhood


Janus kinase 1


Michaelis-Menton Constant


Long-acting beta-2 agonists




Leukotriene C4 synthase


Messenger ribonucleic acid


Nicotinamide adenine dinucleotide


Nuclear factor kappa B


Poly (ADP-ribose) polymerase 1


Peripheral blood mononuclear cells




Plant homeodomain finger protein 11


Periostin osteoblast-specific factor


Ribonucleic acid


Short-acting beta-2 agonists

Serpin B2

Serpin peptidase inhibitor clade B2


Systemic Lupus Erythematous


Single nucleotide polymorphisms


Serine protease inhibitor kazal type 5


Signal transducer and activator of transcription


T-box transcription factor


T cell antigen receptor γ chain


Transforming growth factor Β


T helper 1


T helper 2


Toll-like receptors


Tumor necrosis factor-α


Maximum rate of the enzyme catalyzed reaction


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Copyright information

© Springer India 2013

Authors and Affiliations

  • Anjana Munshi
    • 1
  • Luciana B. Crotti
    • 2
  • Vandana Sharma
    • 3
  • Sanjeev Sharma
    • 4
  • Luis A. Espinoza
    • 5
  1. 1.Department of Molecular Biology, Institute of Genetics and Hospital for Genetic DiseasesOsmania University, BegumpetHyderabadIndia
  2. 2.Department of BiochemistryUniformed Services University of the Health SciencesBethesdaUSA
  3. 3.Institute of Genetics and Hospital for Genetic DiseasesOsmania University, BegumpetHyderabadIndia
  4. 4.Department of Pharmacology, Apollo Health City, Jubillee HillsHyderabadIndia
  5. 5.Department of Biochemistry and Molecular Biology & Cell BiologyGeorgetown UniversityWashingtonUSA

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