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Pharmacogenomics of Allergy and Asthma

  • Anjana Munshi
  • Luciana B. Crotti
  • Vandana Sharma
  • Sanjeev Sharma
  • Luis A. Espinoza
Chapter

Abstract

Allergy and asthma are the diseases of multifactorial etiologies increasing dramatically all over the world. Numerous factors (e.g., aeroallergen, toxin, pathogen, food, chemical insect debris, and drugs) play a key role in the pathophysiology of allergy and asthma. Recent advances in the field of genetics have led to the identification of genetic factors which are involved not only in the pathogenesis of asthma and allergy but also significantly (60–70 %) contribute toward the interindividual variability to drug response and adverse drug reactions. There are several common categories of medications for treating asthma and allergy. Significant heterogeneity in the efficacy and adverse drug reactions of anti-allergic and anti-asthmatic drugs have been observed and efforts have been made to study the role of genetic determinants in the variable interindividual response to medication. Armed with the knowledge of a patient’s pharmacogenomic information, a clinician could predict the response to certain drugs and adverse drug reactions to improve the efficacy and tolerability of the therapeutic interventions.

Keywords

Glucocorticoid Receptor Food Allergy Peak Expiratory Flow Rate Ipratropium Bromide Morning Peak Expiratory Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ABP

Diamine oxidase

ADAM-33

A disintegrin and metalloproteinase domain-containing protein 33

ADRB2

Beta adrenergic receptors

ADRB-2

Beta-2 adrenergic receptor

ADRs

Adverse Drug Reactions

ALOX5

Arachidonate 5 lipoxygenase

ATP

Adenosine triphosphate

BALF

Bronchoalveolar lavage fluid

cAMP

Cyclic adenosine monophosphate

CCL11

Chemokine (C-C motif) ligand 11

CD-14

Cluster of differentiation 14 (CD14)

CFTR

Cystic fibrosis transmembrane conductance regulator

CHRM2

Cholinergic receptor muscarinic 2

CLCA1

Calcium-activated chloride channel regulator 1

COX-2

Cycloxygenase-2

CRDCP15

Caspase recruitment domain-containing protein 15

CRHR1

Corticotrophin-releasing hormone receptor 1

CYF1P2

Cytoplasmic FMR1-interacting protein

CYP1A2

Cytochrome P450 family 1 subfamily A, polypeptide 2

CYP2E1

Cytochrome P450 family 2 subfamily E, polypeptide 1

CysLTR1

Cysteinyl leukotriene receptor

DEFB1

Defensin beta 1

DNA

Deoxyribonucleic acid

DPP10

Dipeptidyl-peptidase 10

FCER1B

Fc epsilon receptor I beta-chain

FDA

Food and Drug Administration

FKB51

FK506-binding protein 51

FLG

Flaggrin

GATA3

Trans-acting T-Cell-specific transcription factor

GC-R

Glucocorticoid resistant

GC-S

Glucocorticoid sensitive

GM-CSF

Granulocyte-macrophage colony-stimulating factor

GMCSF

Granulocyte-monocyte colony-stimulating factor

GPRA

G protein-coupled receptor for asthma

GSNOR

S-Nitrosoglutathione reductase

GST

Glutathione S-transferase

GWAS

Genome-wide association study

HDC

Histidine decarboxylase

hGR

Human glucocorticoid receptor

HLA

Human leukocyte antigen

HNM

Histamine N-methyl transferase

HRH

Histamine receptor

IFNG

Interferon γ

IFNGR1

Interferon gamma receptor-1

IgE

Immunoglobulin E

IL

Interleukin

IL-1β

Interleukin-1β

ISSAC

The International Study of Asthma and Allergies in Childhood

JAK1

Janus kinase 1

Km

Michaelis-Menton Constant

LABA

Long-acting beta-2 agonists

LT

Leukotriene

LTC4S

Leukotriene C4 synthase

mRNA

Messenger ribonucleic acid

NAD+

Nicotinamide adenine dinucleotide

NF-κB

Nuclear factor kappa B

PARP-1

Poly (ADP-ribose) polymerase 1

PBMC

Peripheral blood mononuclear cells

PDE4D

phosphodiesterase-4D

PHF-11

Plant homeodomain finger protein 11

POSTN

Periostin osteoblast-specific factor

RNA

Ribonucleic acid

SABA

Short-acting beta-2 agonists

Serpin B2

Serpin peptidase inhibitor clade B2

SLE

Systemic Lupus Erythematous

SNPs

Single nucleotide polymorphisms

SPINK5

Serine protease inhibitor kazal type 5

STAT6

Signal transducer and activator of transcription

TBX2

T-box transcription factor

TCγ

T cell antigen receptor γ chain

TGF-β

Transforming growth factor Β

TH1

T helper 1

TH2

T helper 2

TLR

Toll-like receptors

TNF-α

Tumor necrosis factor-α

Vmax

Maximum rate of the enzyme catalyzed reaction

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Copyright information

© Springer India 2013

Authors and Affiliations

  • Anjana Munshi
    • 1
  • Luciana B. Crotti
    • 2
  • Vandana Sharma
    • 3
  • Sanjeev Sharma
    • 4
  • Luis A. Espinoza
    • 5
  1. 1.Department of Molecular Biology, Institute of Genetics and Hospital for Genetic DiseasesOsmania University, BegumpetHyderabadIndia
  2. 2.Department of BiochemistryUniformed Services University of the Health SciencesBethesdaUSA
  3. 3.Institute of Genetics and Hospital for Genetic DiseasesOsmania University, BegumpetHyderabadIndia
  4. 4.Department of Pharmacology, Apollo Health City, Jubillee HillsHyderabadIndia
  5. 5.Department of Biochemistry and Molecular Biology & Cell BiologyGeorgetown UniversityWashingtonUSA

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