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Pharmacogenomics of Analgesics

  • Eugenia Ch. Yiannakopoulou
Chapter

Abstract

Pharmacogenomics investigates interindividual genetic variability in DNA sequence of drug targets, drug-metabolising enzymes or disease genes, RNA expression or protein translation of genes affecting drug response and drug safety. Variation exists in patient response on analgesic treatment in terms of efficacy and safety. This variation may be in part explained by pharmacogenomics. This chapter overviews data on pharmacogenomics of opioids and nonsteroidal anti-inflammatory agents focusing on the effect of genetic variation on efficacy and safety of analgesic agents. However, there is limited level I evidence on this topic. Most data come from case-control studies and case reports. Basic research should focus on the identification of biologically meaningful polymorphisms enabling a hypothesis with biological plausibility driven research in the field of pharmacogenomics of analgesics.

Keywords

Opioid Receptor Poor Metabolisers Extensive Metabolisers A118G Polymorphism CYP2C8 Polymorphism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer India 2013

Authors and Affiliations

  1. 1.Department of Basic Medical Lessons, Faculty of Health and Caring ProfessionsTechnological Educational Institute of AthensAthensGreece

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