Neurogenetics and Nutrigenomics of Reward Deficiency Syndrome (RDS): Stratification of Addiction Risk and Mesolimbic Nutrigenomic Manipulation of Hypodopaminergic Function

  • Kenneth Blum
  • David Han
  • John Giordano
  • Raquel Lohmann
  • Eric R. Braverman
  • Margaret A. Madigan
  • Debmalya Barh
  • John Femino
  • Mary Hauser
  • B. W. Downs
  • Thomas Simpatico


We have entered the genomics era with hope for the future of medicine including psychiatry. Understanding the role of DNA and polymorphic associations with brain reward circuitry has led to a new understanding of all addictive behaviors. We present here a brief review of the role of both neurogenetics and nutrigenomics as cornerstones that link more accurate genetic diagnosis and dopamine D2 agonist therapy to induce dopaminergic activation. Based on numerous experiments we are indeed proposing a novel approach. We challenge the entire recovery field to use these tools, the result of years of scientific research into the nature of addiction, and to incorporate them into treatment programs for patients attending inpatient/outpatient addiction clinics, such as the Genetic Addiction Risk Score (GARS)™ for appropriate RDS diagnosis, Comprehensive Analysis of Reported Drugs (CARD)™ to determine both compliance and abstinence during treatment, natural D2 agonistic therapy (NAAT-KB220™), and, eventually, mRNA (patent pending) to determine pre- and post-candidate gene expressions in reward deficiency syndrome (RDS). We are, therefore, proposing a paradigm shift we have called “Reward Deficiency Solutions System (RDSS)™.”


Brain Reward Process Addiction Mesolimbic System Protracted Abstinence Reward Deficiency Syndrome 


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Copyright information

© Springer India 2013

Authors and Affiliations

  • Kenneth Blum
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • David Han
    • 9
  • John Giordano
    • 10
  • Raquel Lohmann
    • 3
  • Eric R. Braverman
    • 1
    • 3
  • Margaret A. Madigan
    • 8
  • Debmalya Barh
    • 11
  • John Femino
    • 5
    • 12
  • Mary Hauser
    • 5
  • B. W. Downs
    • 8
  • Thomas Simpatico
    • 5
    • 6
  1. 1.Department of Psychiatry, McKnight Brain Institute, College of MedicineUniversity of FloridaGainesvilleUSA
  2. 2.G and G Holistic Addiction Treatment CenterNorth Miami BeachUSA
  3. 3.Department of Clinical NeurologyPath FoundationNew YorkUSA
  4. 4.Institute of Integrative Omics and Applied BiotechnologyPurba MedinipurIndia
  5. 5.Dominion DiagnosticsLLCNorth KingstownUSA
  6. 6.Global Integrated Services Unit, Center for Clinical and Translational Science, College of MedicineUniversity of VermontBurlingtonUSA
  7. 7.Department of Addiction Research and TherapyMalibu Beach Recovery CenterMalibu BeachUSA
  8. 8.Department of NutrigenomicsLifeGen, Inc.AustinUSA
  9. 9.Department of Management Science and StatisticsUniversity of Texas at San AntonioSan AntonioUSA
  10. 10.Department of Holistic MedicineG and G Holistic Addiction Treatment CenterNorth Miami BeachUSA
  11. 11.Centre for Genomics and Applied Gene TechnologyInstitute of Integrative Omics and Applied Biotechnology (IIOAB)Purba MedinipurIndia
  12. 12.Meadows Edge Addiction Recovery CenterNorth KingstownUSA

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