Pharmacogenomics and Personalized Medicine in Mood Disorders

  • Trevor Archer
  • Serafino Ricci
  • Max Rapp Ricciardi


Pharmacogenomics and the search for personalized medicine focus on the attainment of individualized pharmacotherapies that cover genetic variation and target groups of patients that present neurodevelopmental aspects of symptom profiles and biomarkers underlying the pathophysiology of mood disorders. The identification of genetic biomarkers facilitates choice of treatment, prediction of response, and prognosis of outcome over a wide spectrum of symptoms associated with affective states thereby optimizing clinical practice procedures. Several strategies, under development and refinement, show the propensity for derivation of essential elements in the etiopathogenesis of disorder affecting drug efficacy, drug metabolism, and drug adverse effects, e.g., with regard to SSRIs; these include the following: transporter gene expression and genes encoding receptor systems, hypothalamic-pituitary-adrenal axis factors, neurotrophic factors, and inflammatory factors affecting neuroimmune function. Nevertheless, procedural considerations of pharmacogenetics presume the parallel investment of policies and regulations to withstand eventual attempts at misuse thereby ensuring patient integrity.


Depressive Symptom Major Depressive Disorder Mood Disorder Anxiety Sensitivity Postpartum Depression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer India 2013

Authors and Affiliations

  • Trevor Archer
    • 1
  • Serafino Ricci
    • 2
  • Max Rapp Ricciardi
    • 1
  1. 1.Department of PsychologyUniversity of GothenburgGothenburgSweden
  2. 2.Department of Anatomy, Histology, Forensic Medicine and OrthopaedicsSapienza UniversityRomeItaly

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