Skip to main content
SpringerLink
Log in
Book cover

Ovarian Stimulation Protocols pp 135–144Cite as

Luteal Phase Support in Controlled Ovarian Hyperstimulation

  • Chapter

Abstract

Luteal phase is the period between ovulation and either the establishment of a pregnancy or the onset of menses 2 weeks later [1]. Being the latter phase of the ovarian cycle, the luteal phase coincides with the secretory phase of the endometrium.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   49.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   64.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   99.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Fatemi HM, Popovic-Todorovic B, Papanikolaou E, Donoso P, Devroey P. An update of luteal phase support in stimulated IVF cycles. Hum Reprod Update. 2007;13(6):581–90.

    Article  CAS  PubMed  Google Scholar 

  2. Practice Committee of the American Society for Reproductive M. The clinical relevance of luteal phase deficiency: a committee opinion. Fertil Steril. 2012;98(5):1112–7.

    Article  Google Scholar 

  3. Jones GS. Luteal phase defect: a review of pathophysiology. Curr Opin Obstet Gynecol. 1991;3(5):641–8.

    Article  CAS  PubMed  Google Scholar 

  4. Dawood MY. Corpus luteal insufficiency. Curr Opin Obstet Gynecol. 1994;6(2):121–7.

    Article  CAS  PubMed  Google Scholar 

  5. Olson JL, Rebar RW, Schreiber JR, Vaitukaitis JL. Shortened luteal phase after ovulation induction with human menopausal gonadotropin and human chorionic gonadotropin. Fertil Steril. 1983;39(3):284–91.

    CAS  PubMed  Google Scholar 

  6. Tavaniotou A, Albano C, Smitz J, Devroey P. Impact of ovarian stimulation on corpus luteum function and embryonic implantation. J Reprod Immunol. 2002;55(1–2):123–30.

    Article  CAS  PubMed  Google Scholar 

  7. Pirke KM, Schweiger U, Lemmel W, Krieg JC, Berger M. The influence of dieting on the menstrual cycle of healthy young women. J Clin Endocrinol Metab. 1985;60(6):1174–9.

    Article  CAS  PubMed  Google Scholar 

  8. De Cree C. Sex steroid metabolism and menstrual irregularities in the exercising female. Rev Sports Med. 1998;25(6):369–406.

    Article  Google Scholar 

  9. Kajantie E, Phillips DI. The effects of sex and hormonal status on the physiological response to acute psychosocial stress. Psychoneuroendocrinology. 2006;31(2):151–78.

    Article  CAS  PubMed  Google Scholar 

  10. Filicori M, Flamigni C, Meriggiola MC, Ferrari P, Michelacci L, Campaniello E, et al. Endocrine response determines the clinical outcome of pulsatile gonadotropin-releasing hormone ovulation induction in different ovulatory disorders. J Clin Endocrinol Metab. 1991;72(5):965–72.

    Article  CAS  PubMed  Google Scholar 

  11. Cunha-Filho JS, Gross JL, Bastos de Souza CA, Lemos NA, Giugliani C, Freitas F, et al. Physiopathological aspects of corpus luteum defect in infertile patients with mild/minimal endometriosis. J Assist Reprod Genet. 2003;20(3):117–21.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Prior JC. Ovarian aging and the perimenopausal transition: the paradox of endogenous ovarian hyperstimulation. Endocrine. 2005;26(3):297–300.

    Article  CAS  PubMed  Google Scholar 

  13. Daly DC, Walters CA, Soto-Albors CE, Riddick DH. Endometrial biopsy during treatment of luteal phase defects is predictive of therapeutic outcome. Fertil Steril. 1983;40(3):305–10.

    CAS  PubMed  Google Scholar 

  14. Fatemi HM, Kolibianakis EM, Camus M, Tournaye H, Donoso P, Papanikolaou E, et al. Addition of estradiol to progesterone for luteal supplementation in patients stimulated with GnRH antagonist/rFSH for IVF: a randomized controlled trial. Hum Reprod. 2006;21(10):2628–32.

    Article  CAS  PubMed  Google Scholar 

  15. Sohn SH, Penzias AS, Emmi AM, Dubey AK, Layman LC, Reindollar RH, et al. Administration of progesterone before oocyte retrieval negatively affects the implantation rate. Fertil Steril. 1999;71(1):11–4.

    Article  CAS  PubMed  Google Scholar 

  16. Fatemi H. The luteal phase and ovarian stimulation. Eur Obstet Gynecol. 2009;4(1):26–9.

    Google Scholar 

  17. Kerin JF, Broom TJ, Ralph MM, Edmonds DK, Warnes GM, Jeffrey R, et al. Human luteal phase function following oocyte aspiration from the immediately preovular graafian follicle of spontaneous ovular cycles. Br J Obstet Gynaecol. 1981;88(10):1021–8.

    Article  CAS  PubMed  Google Scholar 

  18. Smitz J, Erard P, Camus M, Devroey P, Tournaye H, Wisanto A, et al. Pituitary gonadotrophin secretory capacity during the luteal phase in superovulation using GnRH-agonists and HMG in a desensitization or flare-up protocol. Hum Reprod. 1992;7(9):1225–9.

    CAS  PubMed  Google Scholar 

  19. Miyake A, Aono T, Kinugasa T, Tanizawa O, Kurachi K. Suppression of serum levels of luteinizing hormone by short- and long-loop negative feedback in ovariectomized women. J Endocrinol. 1979;80(3):353–6.

    Article  CAS  PubMed  Google Scholar 

  20. Albano C, Grimbizis G, Smitz J, Riethmuller-Winzen H, Reissmann T, Van Steirteghem A, et al. The luteal phase of nonsupplemented cycles after ovarian superovulation with human menopausal gonadotropin and the gonadotropin-releasing hormone antagonist Cetrorelix. Fertil Steril. 1998;70(2):357–9.

    Article  CAS  PubMed  Google Scholar 

  21. Albano C, Smitz J, Camus M, Riethmuller-Winzen H, Siebert-Weigel M, Diedrich K, et al. Hormonal profile during the follicular phase in cycles stimulated with a combination of human menopausal gonadotrophin and gonadotrophin-releasing hormone antagonist (Cetrorelix). Hum Reprod. 1996;11(10):2114–8.

    Article  CAS  PubMed  Google Scholar 

  22. Beckers NG, Macklon NS, Eijkemans MJ, Ludwig M, Felberbaum RE, Diedrich K, et al. Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilization patients after ovarian stimulation with recombinant follicle-stimulating hormone and GnRH antagonist cotreatment. J Clin Endocrinol Metab. 2003;88(9):4186–92.

    Article  CAS  PubMed  Google Scholar 

  23. Fauser BC, Devroey P. Reproductive biology and IVF: ovarian stimulation and luteal phase consequences. Trends Endocrinol Metab. 2003;14(5):236–42.

    Article  CAS  PubMed  Google Scholar 

  24. Edwards RG, Steptoe PC, Purdy JM. Establishing full-term human pregnancies using cleaving embryos grown in vitro. Br J Obstet Gynaecol. 1980;87(9):737–56.

    Article  CAS  PubMed  Google Scholar 

  25. Fanchin R, De Ziegler D, Bergeron C, Righini C, Torrisi C, Frydman R. Transvaginal administration of progesterone. Obstet Gynecol. 1997;90(3):396–401.

    Article  CAS  PubMed  Google Scholar 

  26. Schindler AE, Campagnoli C, Druckmann R, Huber J, Pasqualini JR, Schweppe KW, et al. Classification and pharmacology of progestins. Maturitas. 2008;61(1–2):171–80.

    Article  PubMed  Google Scholar 

  27. Wiweko B, Iljanto S, Natadisastra M, Hestiantoro A, Soebijanto S. Progesterone level on day hCG as a predictor of endometrial receptivity. Indones J Obstet Gynecol. 2009;33–2:118–23.

    Google Scholar 

  28. Var T, Tonguc EA, Doganay M, Gulerman C, Gungor T, Mollamahmutoglu L. A comparison of the effects of three different luteal phase support protocols on in vitro fertilization outcomes: a randomized clinical trial. Fertil Steril. 2011;95(3):985–9.

    Article  PubMed  Google Scholar 

  29. Tonguc E, Var T, Ozyer S, Citil A, Dogan M. Estradiol supplementation during the luteal phase of in vitro fertilization cycles: a prospective randomised study. Eur J Obstet Gynecol Reprod Biol. 2011;154(2):172–6.

    Article  CAS  PubMed  Google Scholar 

  30. Lin H, Li Y, Li L, Wang W, Zhang Q, Chen X, et al. Oral oestradiol supplementation as luteal support in IVF/ICSI cycles: a prospective, randomized controlled study. Eur J Obstet Gynecol Reprod Biol. 2013;167(2):171–5.

    Article  CAS  PubMed  Google Scholar 

  31. Jee BC, Suh CS, Kim SH, Kim YB, Moon SY. Effects of estradiol supplementation during the luteal phase of in vitro fertilization cycles: a meta-analysis. Fertil Steril. 2010;93(2):428–36.

    Article  CAS  PubMed  Google Scholar 

  32. Kolibianakis EM, Venetis CA, Papanikolaou EG, Diedrich K, Tarlatzis BC, Griesinger G. Estrogen addition to progesterone for luteal phase support in cycles stimulated with GnRH analogues and gonadotrophins for IVF: a systematic review and meta-analysis. Hum Reprod. 2008;23(6):1346–54.

    Article  CAS  PubMed  Google Scholar 

  33. van der Linden M, Buckingham K, Farquhar C, Kremer JA, Metwally M. Luteal phase support for assisted reproduction cycles. Cochrane Database Syst Rev. 2011;(10):CD009154.

    Google Scholar 

  34. Levine H, Watson N. Comparison of the pharmacokinetics of Crinone 8% administered vaginally versus Prometrium administered orally in postmenopausal women. Fertil Steril. 2000;73(3):516–21.

    Article  CAS  PubMed  Google Scholar 

  35. Mochtar MH, Van Wely M, Van der Veen F. Timing luteal phase support in GnRH agonist down-regulated IVF/embryo transfer cycles. Hum Reprod. 2006;21(4):905–8.

    Article  CAS  PubMed  Google Scholar 

  36. Schmidt KL, Ziebe S, Popovic B, Lindhard A, Loft A, Andersen AN. Progesterone supplementation during early gestation after in vitro fertilization has no effect on the delivery rate. Fertil Steril. 2001;75(2):337–41.

    Article  CAS  PubMed  Google Scholar 

  37. Vaisbuch E, de Ziegler D, Leong M, Weissman A, Shoham Z. Luteal-phase support in assisted reproduction treatment: real-life practices reported worldwide by an updated website-based survey. Reprod Biomed Online. 2014;28(3):330–5.

    Google Scholar 

  38. Das M, Holzer HE. Recurrent implantation failure: gamete and embryo factors. Fertil Steril. 2012;97(5):1021–7.

    Article  PubMed  Google Scholar 

  39. Simon A, Laufer N. Repeated implantation failure: clinical approach. Fertil Steril. 2012;97(5):1039–43.

    Article  PubMed  Google Scholar 

  40. Tzafettas J, Petropoulos P, Psarra A, Delkos D, Papaloukas C, Giannoulis H, et al. Early antiplatelet and antithrombotic therapy in patients with a history of recurrent miscarriages of known and unknown aetiology. Eur J Obstet Gynecol Reprod Biol. 2005;120(1):22–6.

    Article  CAS  PubMed  Google Scholar 

  41. Nelson SM, Greer IA. The potential role of heparin in assisted conception. Hum Reprod Update. 2008;14(6):623–45.

    Article  CAS  PubMed  Google Scholar 

  42. Norwitz ER, Schust DJ, Fisher SJ. Implantation and the survival of early pregnancy. N Engl J Med. 2001;345(19):1400–8.

    Article  CAS  PubMed  Google Scholar 

  43. Chen Y, Wu XX, Tan JP, Liu ML, Liu YL, Zhang JP. Effects of low molecular weight heparin and heparin-binding epidermal growth factor on human trophoblast in first trimester. Fertil Steril. 2012;97(3):764–70.

    Article  CAS  PubMed  Google Scholar 

  44. Noci I, Milanini MN, Ruggiero M, Papini F, Fuzzi B, Artini PG. Effect of dalteparin sodium administration on IVF outcome in non-thrombophilic young women: a pilot study. Reprod Biomed Online. 2011;22(6):615–20.

    Article  CAS  PubMed  Google Scholar 

  45. Berker B, Taskin S, Kahraman K, Taskin EA, Atabekoglu C, Sonmezer M. The role of low-molecular-weight heparin in recurrent implantation failure: a prospective, quasi-randomized, controlled study. Fertil Steril. 2011;95(8):2499–502.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetric and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jl. Diponegoro 71, Jakarta, 16430, Indonesia

    Budi Wiweko MD, OG(REI), PhD

Authors
  1. Budi Wiweko MD, OG(REI), PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Budi Wiweko MD, OG(REI), PhD .

Editor information

Editors and Affiliations

  1. 1st floor, Rotunda-CHR 36, Mumbai, India

    Gautam N. Allahbadia

  2. IVF Namba Clinic, Osaka, Japan

    Yoshiharu Morimoto

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer India

About this chapter

Cite this chapter

Wiweko, B. (2016). Luteal Phase Support in Controlled Ovarian Hyperstimulation. In: Allahbadia, G., Morimoto, Y. (eds) Ovarian Stimulation Protocols. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1121-1_11

Download citation

  • DOI: https://doi.org/10.1007/978-81-322-1121-1_11

  • Publisher Name: Springer, New Delhi

  • Print ISBN: 978-81-322-1120-4

  • Online ISBN: 978-81-322-1121-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation