DNA as a master molecule in the cell has generally been regarded as static, with the only movement associated being at the time of chromatid/chromosome separation during cell division. This notion stayed for a long time, and, in fact, allowed geneticists to generate extensive linkage maps wherein a gene was assigned a fixed location on the chromosome. Such maps have served many useful purposes in genetic analyses in all organisms in the years to come, and still constitute an important exercise in genetics. However, in the 1940s Barbara McClintock described genetic elements in maize, which had the capacity to move around the genome. Calling them “controlling elements”, McClintock was able to show that their mobility greatly influences the gene expression.
Insertion Sequence Target Site Duplication Strand Transfer Transposition Activity attC Site
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