Gene Mutation: The Basic Mechanism for Generating Genetic Variability



While the life on this earth may have begun as RNA world, DNA is eventually the genetic material of all living organisms, from bacteria to humans. The only exception comes from some viruses with RNA genome, but then viruses themselves cannot be classified as true organisms. DNA is organized into discrete units, called genes, which not only control the particular characters of an organism but also maintain the genetic continuity as they are passed on from generation to generation. The genes are highly stable and thus have been responsible for maintaining the stability and continuity of a species. Implicit in this stability is the generation of variation, a critical parameter for biological evolution. One can talk of these variations at two levels: (1) The variation that takes place in a character and allows the differences to arise in the members of the same species. (2) The biological variations that accumulate in a population and guide the natural selection and thus the evolution.


Repair Pathway Replication Fork Spontaneous Mutation Auxotrophic Mutation Base Analog 
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Further Readings

  1. Benedicte M (2005) After 30 years of study, the bacterial SOS response still surprises us. PLoS Biol 3(7):e255CrossRefGoogle Scholar
  2. Carter P (1986) Site-directed mutagenesis. Biochem J 237:1–7PubMedGoogle Scholar
  3. Griffith AJF, Wessler SR, Lewontin RC, Carrol SB (2008) Introduction to Genetic Analysis 9th Edition. W.H. Freeman and Company, N.YGoogle Scholar
  4. Hastings PJ, Slack A, Petrosino JF, Rosenberg SM (2004) Adaptive amplification and point mutation are independent mechanisms: evidence for various stress-inducible mutation mechanisms. PLoS Biol 2(12):e399PubMedCrossRefGoogle Scholar
  5. Janion C (2008) Inducible SOS response system of DNA repair in Escherichia coli. Int J Biol Sci 4(6):338–344PubMedCrossRefGoogle Scholar
  6. Klug WS, Cummings MR (2003) Concepts of Genetics. 7th Edition. Pearson Education Inc, San FranciscoGoogle Scholar
  7. Krebs JE, Goldstein ES, Kilpatrick ST (2006) Lewin’s essential genes, 2nd edn. Jones & Bartlettl, BostonGoogle Scholar
  8. Miesfield R (2001) DNA libraries and mutagenesis.
  9. Morimatsu K, Kowalczykowski SC (2003) RecFOR proteins load RecA protein onto gapped DNA to accelerate DNA strand exchange: a universal step of recombinational repair. Mol Cell 11(5):1337–1347PubMedCrossRefGoogle Scholar
  10. Patel M, Jiang Q, Woodgate R, Cox MM, Goodman MF (2010) A new model for SOS-induced mutagenesis: how RecA protein activates DNA polymerase V. Crit Rev Biochem Mol Biol 45(3):171–184PubMedCrossRefGoogle Scholar
  11. Rice, K.P. and Cox, M.M. 2001. Recombinational DNA repair in bacteria: post-replication. Encyclopaedia of Life Sciences. Nature Publ. groupGoogle Scholar
  12. Roth JR, Kugelberg E, Reams AB, Kofoid E, Andersson DI (2006) Origin of mutations under selection : the adaptive mutation controversy. Annu Rev Micrbiol 60:477–501CrossRefGoogle Scholar
  13. Smith KC (2004) Recombinational DNA repair: the ignored repair system. BioEssays 26:1322–1326PubMedCrossRefGoogle Scholar
  14. Wright BC (2000) A biochemical mechanism for non-random mutations and evolution. J Bact 182(11):2993–3001PubMedCrossRefGoogle Scholar

Copyright information

© Springer India 2013

Authors and Affiliations

  1. 1.Department of GeneticsUniversity of Delhi, South CampusNew DelhiIndia

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