Abstract
Cancer is amongst the most devastating uncontrolled cellular growth that hampers the growth of normal cells leading to their malfunctioning and organ failure. Anticancer agents are widely used to limit the progression of cancer; however, it suffers from severe side effects. Development of novel modes of drug delivery has minimized the side effects and has increased the therapeutic index of drugs. In the current work, chondroitin sulfate-coupled liposomes of docetaxel were prepared and characterized. The formulation was also studied for in vivo efficacy and biodistribution. The formulation effectively enhanced the life period of experimental animals, which reflects the success of formulation. Thus, use of chondroitin sulfate-coupled docetaxel-loaded liposomes could be advocated to treat cancer. However, systemic in vivo studies are required to extrapolate its effects on humans.
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Ganeshpurkar, A. et al. (2013). Chondroitin Sulfate Surface Engineered Docetaxel-Loaded Liposomes for Tumor Targeting: Design, Development, and Characterization. In: Kumar, V., Bhatele, M. (eds) Proceedings of All India Seminar on Biomedical Engineering 2012 (AISOBE 2012). Lecture Notes in Bioengineering. Springer, India. https://doi.org/10.1007/978-81-322-0970-6_9
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DOI: https://doi.org/10.1007/978-81-322-0970-6_9
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