Fine Mapping



The ultimate aim of molecular genetic studies of quantitative genetic variation is to find the genes that influence the trait. However, the use of MAS does not require the gene to be known, but can be effective with linked markers. So, the critical point is how closely a QTL is mapped with respect to the markers. Several simulation studies have shown that for MAS, informative markers that flank a QTL within 5 cM seem adequate. In contrast, virtually all QTL-mapping studies have been conducted with panels of 100–300 markers covering the entire genome, corresponding to an average distance between markers of ∼5 and 20 cM. Hence, it is imperative to fine map at least those QTL regions with more number of markers. Such mapping process is also referred to as high-resolution mapping.


Fine Mapping Massively Parallel Signature Sequencing Putative Candidate Gene Genetical Genomic Quantitative Genetic Variation 
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Literature Cited

  1. Monna L, Kitazawa N et al (2002) Positional cloning of rice semi-dwarfing gene, sd1: rice “GreenRevolution Gene” encodes a mutant enzyme involvedin gibberellin synthesis. DNA Res 9:11–17PubMedCrossRefGoogle Scholar
  2. Jansen RC, Nap JP (2001) Genetical genomics: the added value from segregation. Trends Genet 17:388–391PubMedCrossRefGoogle Scholar

Further Readings

  1. Holloway B, Li B (2010) Expression QTLs: applications for crop improvement. Mol Breed 26:381–391CrossRefGoogle Scholar
  2. Kliebenstein D (2009) Quantitative genomics: analyzing intraspecific variation using global GeneExpression poly­morphisms or eQTLs. Annu Rev Plant Biol 60:93–114PubMedCrossRefGoogle Scholar
  3. ParanI ZD (2003) Quantitative traits in plants: beyond the QTL. Trends Genet 19(6):303–306CrossRefGoogle Scholar

Copyright information

© Springer India 2013

Authors and Affiliations

  1. 1.Plant Molecular Biology & BioinformaticsTamil Nadu Agricultural UniversityCoimbatoreIndia

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