Abstract
Heat stress suppresses different components of the immune system and thereby enhances susceptibility of an animal to various diseases. Some of the responses of heat stress can be prevented or overcome through alternative management practices and some nutritional strategies. Thermal stress imposes significant economic burden on the productivity of cows and buffaloes. Homeothermic processes within a reasonable limit bring back the immune system to a baseline response level after an immune challenge due to heat stress. Haematopoietic system reacts by decreasing erythrocytes, haemoglobin and packed cell volume during heat stress. The responses of the immune system are of innate and adaptive type. Livestock species of significant economic importance like cattle and buffaloes have a large population of lymphocytes in their blood, and T-lymphocytes recognise antigens through membrane receptors and are responsible for the regulation of the immune response. The immune system of cows contains a large proportion of γδ T-lymphocytes, and the number varies with age and is considerably higher in young animals than in adults, where they constitute 5–10% of the total peripheral blood lymphocytes. The higher concentration of catecholamine exhibits a negative impact on immunity of heat-exposed cells through IL-1α and IL-1β. Glucocorticoids and catecholamines, through their effects on Th1 and Th2 cytokine secretion, may cause suppression of cellular immunity and cause a shift towards Th2-mediated humoral immunity. Acute and chronic stressors affect the immune responses, and these responses may vary. Chronic stress most often leads to suppression or dysfunction of innate and adaptive immune responses however, acute responses may be variable, that is, immunosuppressive or immunomodulator (Dhabhar and McEwen 2006). The use of various nutritional strategies to enhance the immune system of livestock throughout various stages of production has been investigated extensively, and ameliorative measures have been suggested. Some of the nutritional supplements suggested may be used to enhance immune functions. Vitamin E and Zn have received most attention as immune-stimulatory nutrients. Micro-minerals modulate immune responses primarily through their critical roles in enzyme activity or efficiency complex, and a deficiency or an excess of minerals can alter the activities of the immune system.
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Abdel-Samee AM (1987) The role of cortisol in improving productivity of heat-stressed farm animals with different techniques. PhD thesis, Faculty of Agriculture, Zagazig University, Zagazig
Aggarwal A, Ashutosh, Chandra G, Singh AK (2012) Heat shock protein 70, oxidative stress and antioxidant status in periparturient crossbred cows supplemented with α-tocopherol acetate. Trop Anim Health Prod. doi:10.1007/s11250-012-0196-z
Aitken SL, Karcher EL, Rezemand P (2009) Evaluation of antioxidant and proinflammatory gene expression in bovine mammary tissue during the periparturient period. J Dairy Sci 92:589–598
AL-Saiady MY, AL-Saiskh MA, AL-Mufarrej SI, Al-Showeimi TA, Mogawer HH, Dirrara A (2004) Effect of chelated chromium supplementation on lactation performance and blood parameters of Holstein cows under heat stress. Anim Feed Sci Technol 117:223–233
Amaral BC, Connor EE, Tao S, Hayen J, Bubolz J, Dahl GE (2010) Heat stress abatement during the dry period influences prolactin signaling in lymphocytes. Domest Anim Endocrinol 38:38–45
Ando M, Katagiri K, Yamamoto S, Wakamatsu K, Kawahara I, Asanuma S, Usuda M, Sasaki K (1997) Age-related effects of heat stress on protective enzymes for peroxides and microsomal monooxygenase in rat liver. Environ Heal Perspect 105:726–733
Andrieu S (2008) Is there a role for organic trace element supplements in transition cow health? Vet J 176:77–83
Baldwin CL, Sathiyaseelan T, Naiman B, White AM, Brown R, Blumerman S, Rogers A, Black SJ (2002) Activation of bovine peripheral blood γδ T cells for cell division and IFN-γ production. Vet Immunol Immunopathol 87:251–259
Bernabucci U, Ronchi B, Lacetera N, Nardone A (2002) Markers of oxidative status in plasma and erythrocytes of transition dairy cows during hot season. J Dairy Sci 85:2173–2179
Berry MJ, Kedffer JD, Harney JW, Larsen PR (1991) Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase. J Biol Chem 266:14155–14158
Blecha F, Baker PE (1986) Effect of cortisol in vitro and in vivo on production of bovine interleukin 2. Am J Vet Res 47:841–845
Blokhina O, Virolainen E, Fagerstedt KV (2003) Antioxidants, oxidative damage and oxygen deprivation stress: a review. Ann Bot (Lond) 91:179–194
Blotta MH, DeKruyff RH, Umestsu DT (1997) Corticosteriods inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes. J Immunol 158:5589–5595
Bluestone JA, Khattri R, Sciammas R, Sperling AI (1995) TCRγδ cells: A specialized T-cell subset in the immune system. Annu Rev Cell Dev Biol 11:307–353
Bonnette ED, Kornegay ET, Lindemann MD, Hammerberg C (1990) Humoral and cell-mediated immune response and performance of weaned pigs fed four supplemental vitamin E levels and housed at two nursery temperatures. J Anim Sci 68:1337–1345
Borel JS, Majerus TC, Polansky MM (1984) Chromium intake and urinary chromium excretion of trauma patients. Biol Trace Elem Res 6:317–326
Borgs P, Mallard BA (1998) Immune-endocrine interactions in agricultural species: chromium and its effect on health and performance. Domest Anim Endocrinol 15:431–438
Bot A, Smith KA, Von Herrath M (2004) Molecular and cellular control of T1/T2 immunity at the interface between antimicrobial defense and immune pathology. DNA Cell Biol 23:341–350
Burdick NC, Carroll JA, Hulbert LE, Dailey JW, Ballou MA, Randel RD, Willard ST, Rhonda CV, Welsh TH Jr (2011) Temperament influences endotoxin-induced changes in rectal temperature, sickness behavior, and plasma epinephrine concentrations in bulls. Innate Immun 4:355–364
Burton JL, Mallard BA, Mowat DN (1993) Effects of supplemental chromium on immune responses of periparturient and early lactation dairy cows. J Anim Sci 71:1532–1539
Calder PC, Kew S (2002) The immune system: a target for functional foods? Br J Nutr 88:165–176
Carr AC, Frei B (1999) Does vitamin C act as pro-oxidant under physiological conditions? FASEB J 13:1007–1024
Carroll JA, Forsberg NE (2007) Influence of stress and nutrition on cattle immunity. Vet Clin Food Anim 23:105–149
Chandra G (2009) Antioxidative status of high body condition periparturient crossbred cows with and without supplementation of α-Tocopherol acetate during summer and winter seasons. M.V.Sc. thesis, NDRI (deemed University), Karnal
Chandra G, Aggarwal A (2009) Effect of DL-α-tocopherol acetate on calving induced oxidative stress in periparturient crossbred cows during summer and winter seasons. Indian J Anim Nutr 26(3):204–210
Chandra G, Aggarwal A (2010) Effect of DL- α-tocopherol acetate on calving induced oxidative stress in peripartureint crossbred cows during summer and winter seasons. Indian J Anim Nutr 26:204–210
Chandra S, Chandra RK (1986) Nutrition, immune response and outcome. Prog Food Nutr Sci 10:1–65
Chang X, Mallard BA, Mowat DN (1996) Effects of chromium on health status, blood neutrophil phagocytosis and in vitro lymphocyte blastogenesis of dairy cows. Vet Immunol Immunopathol 52:37–52
Chaudiere J, Tappel AL (1984) Interaction of gold (I) with the active site of selenium-glutathione peroxidase. J Inorg Biochem 20:313–325
Chawla R, Kaur H (2005) Effect of supplemental vitamin E and β-carotene on cell-mediated immunity and mastitis in crossbred cows. Anim Nutr Feed Technol 5:73–84
Chew BP, Park JS (2004) Carotenoid action on the immune response. J Nutr 134:257–261
Coffman RL (2006) Origins of the Th1-Th2 model: a person perspective. Nat Immunol 7:539–541
Constant SL, Bottomly K (1997) Induction of Th1 and Th2 CD4+ T cell response: the alternative approach. Annu Rev Immunol 15:297–322
Cook NB, Bennett TB, Emery KM, Nordlund KV (2002) Monitoring nonlactating cow intramammary infection dynamics using DHI somatic cell count data. J Dairy Sci 85:1119–1126
Cusack PMV, McMeniman NP, Lean IJ (2005) The physiological and production effects of increased dietary intake of vitamins E and C in feedlot cattle challenged with bovine herpesvirus 1. J Anim Sci 83:2423–2433
Dahlquist SP, Chew BP (1985) Effects of vitamin A and B-carotene on mastitis in dairy cows during the early dry period. J Dairy Sci 68:191
Dalpke K, Heeg H, Bartz Baetz A (2008) Regulation of innate immunity by suppressors of cytokine signaling (SOCS) proteins. Immunobiology 213:225–235
de Jong EC, Vierira PL, Kalinski P, Kapsenberg ML (1999) Corticosteriods inhibit the production of inflammatory mediators in immature monocyte-derived DC and induce development of tolerogenic DC3. J Leukoc Biol 66:201–204
DeKruyff RH, Yang Y, Umetsu DT (1998) Corticosteriods enhance the capacity of macrophages to induce TH2 cytokine synthesis in CD4+ lymphocytes by inhibiting IL-12 production. J Immunol 160:2231–2237
Devaraj C, Upadhyay RC (2007) Effect of catecholamines and thermal exposure on lymphocyte proliferation, IL-1α & β in buffaloes. Ital J Anim Sci 6(suppl 2):1336–1339
Dhabhar FS, McEwen BS (2006) Bidirectional effects of stress on immune function: possible explanations for salubrious as well as harmful effects. In: Ader R, editor. Psychoneuroimmunology. 4th ed. San Diego (CA): Elsevier
Eicher SD, Morrill JL, Blecha F, Chitko-McKown CG, Anderson NV, Higgins JJ (1994) Leukocyte functions of young dairy calves fed milk replacers supplemented with vitamins A and E. J Dairy Sci 77:1399–1407
Eitam H, Brosh A, Orlov A, Izhaki I, Shabtay A (2009) Caloric stress alters fat characteristics and Hsp70 expression in somatic cells of lactating beef cows. Cell Stress Chaperones 14:173–182
Elenkov IJ (2002) Systemic stress-induced Th2 shift and its clinical implications. Int Rev Neurobiol 52:163–186
Elenkov IJ, Chrousos GP (2002) Stress hormones, pro-inflammatory, and anti-inflammatory cytokines and autoimmunity. Ann N Y Acad Sci 96:290–303
Elenkov IJ, Papanicolaou DA, Wilder RL, Chrousos GP (1996) Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: clinical implications. Proc Assoc Am Physicians 108:374–381
Elenkov IJ, Chrousos GP, Wilder RL (2000) Neuroendocrine regulation of IL-12 and TNF-α/IL-10 balance. Ann N Y Acad Sci 917:94–105
Elvinger F, Hansen PJ, Natzke RP (1991) Modulation of function of bovine polimorphonuclear leukocytes and lymphocytes by high temperature in vitro and in vivo. Am J Vet Res 52:1692–1698
Enjalbert F, Lebreton P, Salat O (2006) Effects of copper, zinc and selenium status on performance and health in commercial dairy and beef herds, retrospective study. J Anim Physiol Anim Nutr 90:459–466
Erickson KL, Medina EA, Hubbard NE (2000) Micronutrients and innate immunity. J Infect Dis 182(Suppl 1):5–10
Evock-Clover CM, Polansky MM, Anderson RA (1993) Dietary chromium supplementation with or without somatotropin treatment alters serum hormones and metabolites in growing pigs without affecting growth performance. J Nutr 123:1504–1512
Frankenburg S, Wang X, Milner Y (1998) Vitamin A inhibits cytokines produced by type 1 lymphocytes in vitro. Cell Immunol 185:75–81
Fulford AJ, Harbuz MS (2005) An introduction to the HPA. In: Steckler T, Kalin NH, Reul JMHM (eds) Handbook of stress and the brain. Elsevier, Amsterdam, pp 43–66
Grignard E, Morin J, Vernet P, Drevet JR (2005) GPX5 orthologs of the mouse epididymis-restricted and sperm-bound selenium-independent glutathione peroxidase are not expressed with the same quantitative and spatial characteristics in large domestic animals. Theriogenology 64:1016–1033
Grimble RF (2001) Symposium on evidence-based nutrition. Nutritional modulation of immune function. Proc Nutr Soc 60:389–397. doi:10.1079/PNS2001102
Habeeb AAM (1987) The role of insulin in improving productivity of heat stressed farm animals with different techniques. Ph.D. Thesis, Faculty of Agriculture, Zagazig University, Zagazig, Egypt
Hahn GL, Mader TL, Harrington JA, Nienaber JA, Frank KL (2002) Living with climatic variability and potential global change: climatological analyses of impacts on livestock performance. In: Proceedings of the 16th international congress on biometeorology, Kansas City, pp 45–49
Halliwell B (1987) Oxidants and human disease: some new concepts. Fed Am Soc Biol J 1:398
Hara S (2001) Effects of selenium deficiency on expression of selenoproteins in bovine arterial endothelial cells. Biol Pharm Bull 24:754–759
Harmon RJ, Torre PM (1994) Copper and zinc: do they influence mastitis? In: Proceedings of National Mastitis Council, Orlando, pp 54–56
Hasselmann L, Munchow H, Menzke V, Schneewei TR, Ahrens F (2000) Influence of β-carotene supplementation on cell count of raw milk as well as on reproductive performance of dairy cows under practical conditions. Nutr Abstr Rev (B) 70:708
Hayirli A, Bremmer DR, Bertics SJ, Socha MT, Grummer RR (2001) Effect of chromium supplementation on production and metabolic parameters in periparturient dairy cows. J Dairy Sci 84:1218–1230
Hein WR, Mackay CR (1991) Prominence of gamma delta T cells in ruminant immune system. Immunol Today 12:30–34
Hicks TA, McGlone JJ, Whisnant CS, Kattesh HG, Norman RL (1998) Behavioral, endocrine, immune and performance measures for pigs exposed to acute stress. J Anim Sci 76:474–483
Hogan JS, Smith KL, Weiss WP, Todhunter DA, Schockey WL (1990) Relationship among vitamin E, selenium and bovine blood neutrophils. J Dairy Sci 73:2372–2378
Holstenius P (1993) Hormonal regulation related to the development of fatty liver and ketosis. Acta Vet Scand 89:55–60
Hornef MW, Frisan T, Vandewalle A, Normark S, Richter-Dahlfors A (2002) Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells. J Exp Med 195:559–570
Horst RD (1986) Regulation of calcium and phosphorous homeostasis in dairy cows. J Dairy Sci 69:604–616
Irwin M, Vale W, Rivier C (1990) Central corticotropin-releasing factor mediates the suppressive effect of stress on natural killer cell cytotoxicity. Endocrinology 126:2837–2844
Ishizaki H, Kariya Y (1999) Effects of peripheral blood polymorphonuclear leukocyte function and blood components in Japanese Black steers administered ACTH in a cold environment. J Vet Med Sci 61:487–492
Ishizaki H, Hanafusa Y, Kariya Y (2005) Influence of truck-transportation on the function of bronchoalveolar lavage fluid cells in cattle. Vet Immunol Immunopathol 105:67–74
Ismaili J, Olislagers V, Poupot R, Fournié JJ, Goldman M (2002) Human γδ T cells induce dendritic cell maturation. Clin Immunol 103:296–302
Janeway CA, Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20:197–216
Janeway CA, Travers P, Walport M, Shlomchik M (2001) Basic concepts in immunology. In: Janeway CA, Travers P, Walport M, Shlomchik M (eds) Immunobiology: the immune system in health and disease. Garland Publishing, New York, pp 1–34
Johnson RW, Von Borell EH, Anderson LL, Kojic LD, Cunnick JE (1994) Intracerebroventricular injection of corticotrophin-releasing hormone in the pig: acute effects on behavior, adrenocorticotropin secretion and immune suppression. Endocrinology 135:642–648
Kamwanja LA, Chase CC, Gutierrez JA, Guerriero V, Olson TA, Hammond AC, Hansen PJ (1994) Responses of bovine lymphocytes to heat shock as modified by breed and antioxidant status. J Anim Sci 72:438–444
Kehri ME Jr, Burton JL, Nonnecke BJ, Lee EK (1999) Effects of stress on leukocytes trafficking and immune responses: implications for vaccination. Adv Vet Med 41:61–81
Kelley KW (1982) Immunobiology of domestic animals as affected by hot and cold weather. In: Proceedings of the second international livestock environment symposium. ASAE Publication No. 3–82, St. Joseph, Michigan, pp 470–483
Kelley KW, Osborne CA, Evermann JF, Parish SM, Gaskins CT (1982a) Effects of chronic heat and cold stressors on plasma immunoglobulin and mitogen-induced blastogenesis in calves. J Dairy Sci 65:1514–1528
Kelley KW, Greenfield RE, Evermann JF, Parish SM, Perryman LE (1982b) Delayed-type hypersensitivity, contact sensitivity, and phytohemagglutinin skin-test responses of heat- and cold-stressed calves. Am J Vet Res 43:775–779
Kidd P (2003) Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern Med Rev 8:223–246
Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, Ohishi M, Yoshida H, Kubo M, Yoshimura A (2002) SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17:583–591
Kronfeld DS (1976) The potential importance of the proportions of glucogenic, lipogenic and aminogenic nutrients in regard to the health and productivity of dairy cows. Adv Anim Physiol Anim Nutr 7:5–10
Kruse V (1970) Yield of colostrum and immunoglobulin in cattle at the first milking after parturition. Anim Prod 12:619–626
Kruse-Jarres JD (1989) The significance of zinc for humoral and cellular immunity. J Trace Elem Electrol Health Dis 3:1–8
Kushner I (1982) The phenomenon of the acute phase response. Ann N Y Acad Sci 389:39–48
Lacetera N, Bernabucci U, Ronchi B, Scalia D, Nardone A (2002) Moderate summer heat stress does not modify immunological parameters of Holstein dairy cows. Int J Biometeorol 46:33–37
Lacetera N, Bernabucci U, Scalia D, Ronchi B, Kuzminsky G, Nardone A (2005) Lymphocyte functions in dairy cows in hot environment. Int J Biometerol 50:105–110
Levine S (2005) Stress: an historical perspective. In: Steckler T, Kalin NH, Reul JMHM (eds) Handbook of stress and the brain. Elsevier, Amsterdam, pp 3–23
Lohrke B, Viergutz T, Kanitz W, Losand B, Weiss DG, Simko M (2005) Hydroperoxides in circulating lipids from dairy cows, implications for bioactivity of endogenous-oxidized lipids. J Dairy Sci 88:1708–1710
Maddox JF, Aherne KM, Reddy CC, Sordillo LM (1999) Increased neutrophil adherence and adhesion molecule mRNA expression in endothelial cells during selenium deficiency. J Leukoc Biol 65:658
Mallard BA, Dekkers JC, Ireland MJ, Leslie KE, Sharif S, Lacey Vankampen C, Wagter L, Wilkie BN (1998) Alteration in immune responsiveness during the periparturient period and its ramification on dairy cows and calf health. J Dairy Sci 81:585–595
Marai IFM, Habeeb AAM, Daader AH, Yousef HM (1995) Effect of Egyptian subtropical conditions and the heat stress alleviation techniques of water spray and diaphoretics on the growth and physiological functions of Friesian calves. J Arid Environ 30:219–225
Marai IFM, Daader AM, Abdel-Samee AM, Ibrahim H (1997a) Winter and summer effects and their amelioration on lactating Friesian and Holstein cows maintained under Egyptian conditions. In: Proceedings of the international conference on animal, poultry, rabbits and fish production and health, Cairo
Marai IFM, Daader AM, Abdel-Samee AM, Ibrahim H (1997b) Lactating Friesian and Holstein cows as affected by heat stress and combination of amelioration techniques under Egyptian conditions. In: Proceedings of the international conference on animal, poultry, rabbits and fish production and health. Cairo
Markesbery WR, Montine TJ, Lovell M (2001) Oxidative alterations in neurodegenerative diseases. In: Mattson MP (ed) Pathogenesis disorders. Humana Press, Totowa
Maurya P (2011) Leptin level in relation to immunity, energy metabolites and cellular adaptations during dry period and early lactation in crossbred cows. M.V.Sc. thesis, NDRI (deemed University), Karnal
McDowell LR (2003) Minerals in animal and human nutrition. Academic, San Diego
McGlone JJ, Lumpkin EA, Norman RL (1991) Adrenocorticotropin stimulates natural killer cell activity. Endocrinology 129:1653–1658
McGlone JJ, Salak JL, Lumpkin EA, Nicholson RI, Gibson M, Norman RL (1993) Shipping stress and social status effects on pig performance, plasma cortisol, natural killer cell activity, and leukocyte numbers. J Anim Sci 71:888–896
McNamara JP, Valdez F (2005) Adipose tissue metabolism and production responses to calcium propionate and chromium propionate. J Dairy Sci 88:2498–2507
Medzhitov R, Preston-Hulburt P, Janeway CA Jr (1997) A human homologue of the drosophila toll protein signals activation of adaptive immunity. Nature 388:394–397
Michal JJ, Chew B, Wong TS, Heirman LR, Standaert FE (1994) Modulatory effects of dietary β-carotene on blood and mammary leukocyte function in peripartum dairy cows. J Dairy Sci 77:1408–1422
Minton JE (1994) Function of the hypothalamic-pituitary axis and the sympathetic nervous system in models of acute stress in domestic farm animals. J Anim Sci 72:1891–1898
Mishra OK, Hooda Singh G, Meur SK (2011) Influence of induced heat stress on HSP70 in buffalo lymphocytes. J Anim Physiol Anim Nutr 95:540–544
Morrow-Tesch JL, McGlone JJ, Salak-Johnson JL (1994) Heat and social stress effects on pig immune measures. J Anim Sci 72:2599–2609
Mosmann TR, Coffman RL (1989) Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145–173
Mosmann TR, Sad S (1996) The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 17:138–146
Nardone A, Lacetera N, Bernabucci U, Ronchi B (1997) Com- position of colostrum from dairy heifers exposed to high air temperatures during late pregnancy and the early postpartum period. J Dairy Sci 80:838–844
National Research Council (NRC) (2001) Nutrient requirements of dairy cattle. Natl. Acad. Press, Washington, DC
Norrman J, David CW, Sauter SN, Hammon HM, Blum JW (2003) Effects of dexamethasone on lymphoid tissue in the gut and thymus of neonatal calves fed with colostrum or milk replacer. J Anim Sci 81:2322–2332
Panda N, Kaur H (2007) Influence of vitamin E supplementation on spontaneous oxidized flavour of milk in dairy buffaloes. Int J Dairy Technol 60:198–204
Paterson JE, MacPherson A (1990) The influence of low cobalt intake on the neutrophil function and severity of Ostertagia infection in cattle. Br Vet J 146:519–530
Politis I, Hidiroglou N, Batra TR, Gilmore JA, Gorewit RC, Scherf H (1995) Effects of vitamin E on immune function of dairy cows. Am J Vet Res 56:179–184
Pollock JM, Welsh MD (2002) The WC1+ γδ T-cell population in cattle: a possible role in resistance to intracellular infection. Vet Immunol Immunopathol 89:105–114
Reddy PG, Frey RA (1990) Nutritional modulation of immunity in domestic food animals. Adv Vet Sci Comp Med 35:255–281
Reffett JK, Spears JW, Brown TT (1988) Effect of dietary selenium on the primary and secondary immune response in calves challenged with infectious bovine rhinotracheitis virus. J Nutr 118:229–235
Richards DF, Fernandez M, Caulfield J, Hawrylowicz CM (2001) Glucocorticoids drive human CD8(+) T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production. Eur J Immunol 30:2344–2354
Salak JL, McGlone JJ, Lyte M (1993) Effects of in vitro adrenocorticotrophic hormone, cortisol and human recombinant interleukin-2 on porcine neutrophils migration and luminol-dependent chemiluminescence. Vet Immunol Immunopathol 39:327–337
Salak-Johnson JL, McGlone JJ (2007) Making sense of apparently conflicting data: stress and immunity in swine and cattle. J Anim Sci 85:81–88
Salak-Johnson JL, McGlone JJ, Norman RL (1996) In vivo glucocorticoid effects on porcine natural killer cell activity and circulating leukocytes. J Anim Sci 74:584–592
Salak-Johnson JL, McGlone JJ, Whisnant CS, Norman RL, Kraeling RR (1997) Intracerebroventricular porcine corticotrophin-releasing hormone and cortisol effects on pig immune measures and behavior. Physiol Behav 61:15–23
Salem A (1980) Seasonal variations in some body reactions and blood constituents in lactating buffaloes and Friesian cows. J Egypt Vet Med Assoc 40:63
Sapolsky RM, Romero LM, Munck AU (2001) How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 21:55–89
Sasaki A, Yasukawa H, Suzuki A, Kamizono S, Syoda T, Kinjyo I, Sasaki M, Johnston JA, Yoshimura A (1999) Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells 4:339–351
Scaletti RW, Amaral-Phillips DM, Harmon RJ (1999) Using nutrition to improve immunity against disease in dairy cattle: Copper, Zinc, Selenium, and Vitamin E http://www.ca.uky.edu. Issued 4
Scaletti RW, Trammell DS, Smith BA, Harmon RJ (2001) Role of dietary copper in altering response to intramammary E. coli challenge. Pages 29-33 in Proc. Int. Mastitis Symp, Natl Mastitis Counc/Am Assoc Bovine Practitioners, Vancouver, BC, Canada
Semba RD (1994) Vitamin A, immunity and infection. Clin Infect Dis 19:489–499
Shafferi I, Roussel JD, Koonce KX (1981) Effects of age, temperature, season and breed on blood characteristics of dairy cattle. J Dairy Sci 64:63–68
Shearer J, Mohammed HO, Brenneman JS, Tran TQ (1992) Factors associated with concentrations of immunoglobulins in colostrums at the first milking post calving. Prev Vet Med 14:143–154
Shebaita MK, Kamal TH (1973) In vivo body composition in ruminants. I. Blood volume in Friesian and water buffaloes. Alex J Agric Res 1:329–350
Skjolaas KA, Minton JE (2002) Does cortisol bias cytokine production in cultured splenocytes to a Th2 phenotype? Vet Immunol Immunopathol 87:451–458
Skjolaas KA, Grieger DM, Hill CM, Minton JE (2002) Glucocorticoid regulation of type 1 and type 2 cytokines in cultured porcine splenocytes. Vet Immunol Immunopathol 87:79–87
Smith KL, Todhunter DA, Schoenberger PS (1985) Environmental mastitis: cause, prevalence. Prev J Dairy Sci 68:1531
Soper F, Muscoplat CC, Johnson DW (1978) In vitro stimulation of bovine peripheral blood lymphocytes: analysis of variation of lymphocyte blastogenic response in normal dairy cattle. Am J Vet Res 39:1039–1042
Sordillo LM, Streicher KL (2002) Mammary gland immunity and mastitis susceptibility. J Mammary Gland Biol Neoplasia 7:135–146
Sordillo LM, Shafer-Weaver K, DeRosa D (1997) Immunobiology of the mammary gland. J Dairy Sci 80:1851–1865
Spears JW (2000) Micronutrients and immune function in cattle. Proc Nutr Soc 59:587–594
Starr R, Willson TA, Viney EM, Murray LJL, Rayner JR, Jenkin BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ (1997) A family of cytokine-inducible inhibitors of signaling. Nature 387:917–921
Stott G (1980) Immunoglobulin absorption in calf neonates with special considerations of stress. J Dairy Sci 63:681–688
Subiyatno A, Mowat DN, Yang WZ (1996) Metabolite and hormonal responses to glucose or propionate infusions in periparturient dairy cows supplemented with chromium. J Dairy Sci 79:1436–1445
Surai PF, Dvorska JE (2002) Strategies to enhance antioxidant protection and implications for the well-being of companion animals. In: Proceedings of the 18th annual symposium on nutritional biotechnology in the feed and food industry, Lexington, pp 521–534
Surai KP, Surai PF, Speake BK, Sparks NHC (2003) Antioxidant–prooxidant balance in the intestine: food for thought. 1. Prooxidants. Nutr Genomics Funct Foods 1:51–70
Swanson LW, Sawchenko PE (1980) Paraventricular nucleus: a site for the integration of neuroendocrine and autonomic mechanisms. Neuroendocrinology 31:410–417
Swanson LW, Sawchenko PE, Wiegand SJ, Price JL (1980) Separate neurons in the paraventricular nucleus project to the median eminence and to the medulla or spinal cord. Brain Res 198:190–195
Tizard IR (2000) Veterinary immunology: an introduction, 6th edn. W.B. Saunders Company, London, p 482
Todhunter D, Smith KL, Hogan JS (1990) Growth of gram-negative bacteria in dry cow secretion. J Dairy Sci 73:363–372
Tomlinson DJ, Socha MT, Rapp CJ, Johnson AB (2002) Summary of twelve trials evaluating the effect of feeding complexed zinc methionine on lactation performance of dairy cattle. J Dairy Sci 85:106 (abstr.)
Torre PM, Harmon RJ, Sordillo LM, Boissonneault GA, Hemken RW, Trammell DS, Clark TW (1995) Modulation of bovine mononuclear cell proliferation and cytokine production by dietary copper insufficiency. J Nutr Immunol 3:3–20
Traber MG, Arai H (1999) Molecular mechanisms of vitamin E transport. Annu Rev Nutr 19:343–355. doi:10.1146/annurev.nutr.19.1.343 (Volume publication date July 1999)
Trevisan M, Browne R, Ram M, Muti P, Freudenheim JA, Carosella M, Armstrong D (2001) Correlates of markers of oxidative status in the general population. Am J Epidemiol 154:348–356
Trigona WL, Mullarky IK, Cao Y, Sordillo LM (2006) Thioredoxin reductase regulates the induction of haem oxygenase-1 expression in aortic endothelial cells. Biochem J 394:207–216
Trout JM, Mashaly MM (1994) The effects of adrenocorticotropic hormone and heat stress on the distribution of lymphocyte populations in immature male chickens. Poult Sci 73:1694–1698
Underwood EJ (1999) In: Underwood EJ, Suttle N (eds) The mineral nutrition of livestock, 3rd edn. CABI Publishing, Wallingford
Upadhyay RC (2011) Impact of climate change on livestock production and health. In: Proceedings international conference on agriculture. ICICCA, Sri Lanka, pp 19–39
Valentino RJ, Van Bockstaele EJ (2005) Functional interactions between stress neuromediators and the locus coeruleusnorepinephrine system. In: Steckler T, Kalin NH, Reul JMHM (eds) Handbook of stress and the brain. Elsevier, Amsterdam, pp 465–468
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39:44–84
Visser J, Boxel-Dezaire A, Methorst D, Brunt T, De Kloet ER, Nagelkerken L (1998) Differential regulation of interleukin-10 (IL-10) and IL-12 by glucocorticoids in vitro. Blood 91:4255–4264
Waage S, Sviland S, Odegaard SA (1998) Identification of risk factors for clinical mastitis in dairy heifers. J Dairy Sci 81:1275–1284
Wang X, Quinn PJ (2000) The location and function of vitamin E in membranes (review). Mol Membr Biol 17:143–156
Wall EH, Auchtung-Montgomery TL, Dahl GE, Mc- Fadden TB (2005) Short communication: Short day photoperiod during the dry period decreases expression of suppressors of cytokine signaling in the mammary gland of dairy cows. J Dairy Sci 88:3145–3148
Weber PSD, Madsen SA, Smith GW, Ireland JJ, Burton JL (2001) Pre-translational regulation of neutrophil L-selectin in glucocorticoid-challenged cattle. Vet Immunol Immunopathol 83:213–240
Webster AJF (1983) Environmental stress and the physiology, performance and health of ruminants. J Anim Sci 57:1584–1593
Weiss WP (2009) Antioxidant nutrients and milk quality. http://www.extension.org/pages/antioxidant nutrients and milk quality
Whitaker DA, Eayres HF, Aitchison K, Kelly JM (1997) No effect of a dietary zinc proteinate on clinical mastitis, infection rate, recovery rate, and somatic cell count in dairy cows. Vet J 153:197–204
Wiegers GJ, Reul JMHM (1998) Induction of cytokine receptors by glucocorticoids: functional and pathological significance. Trends Pharmacol Sci 19:317–321
Wiegers GJ, Stec IEM, Sterzer P, Ruel JMHM (2005) Glucocorticoids and the immune response. In: Steckler T, Kalin NH, Reul JMHM (eds) Handbook of stress and the brain. Elsevier, Amsterdam, pp 175–191
Williams RS, Thomas JA, Fina M, German Z, Benjamin IJ (1993) Human heat shock protein 70 (hsp70) protects murine cells from injury during metabolic stress. J Clin Invest 92:503–508
Wrona D, Trojniar W, Borman A, Ciepielewski Z, Tokarski J (2001) Stress-induced changes in peripheral natural killer cell cytotoxicity in pigs may not depend on plasma cortisol. Brain Behav Immun 15:54–64
Wu CY, Fargeas C, Nakajima T, Delespesse G (1991) Glucocorticoids suppress the production of interleukin 4 by human lymphocytes. Eur J Immunol 21:2645–2647
Wu CY, Wang K, McDyer JF, Sedev RA (1998) Prostaglandin E2 and dexamethasone inhibit IL-12 receptor expression and IL-12 responsiveness. J Immunol 161:2723–2730
Yang HW, Hwang KJ, Kwon HC, Kim HS, Choi KW, Oh KS (1998) Detection of reactive oxygen species (ROS) and apoptosis in human fragmented embryos. Hum Reprod 13:998–1002
Yeruham I, Elad D, Friedman S, Perl S (2003) Corynebacterium pseudotuberculosis infection in Israeli dairy cattle. Epidemiol Infect 131:947–955
Yoshimura A, Naka T, Kubo M (2007) SOCS proteins, cytokine signaling and immune regulation. Nat Rev Immunol 7:454–465
Yousef HM (1990) Studies on adaptation of Friesian cattle in Egypt. PhD thesis, Faculty of Agriculture, Zagazig University, Zagazig
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Aggarwal, A., Upadhyay, R. (2013). Heat Stress and Immune Function. In: Heat Stress and Animal Productivity. Springer, India. https://doi.org/10.1007/978-81-322-0879-2_5
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