Good Laboratory Practices in Biomonitoring
In the experimental research arena, the phrase good laboratory practice or GLP specifically refers to a quality system of management controls for research laboratories and organisations to try to ensure the uniformity, consistency, reliability, reproducibility, quality and integrity of chemical (including pharmaceuticals) non-clinical safety tests, from physiochemical properties through acute to chronic toxicity tests. GLP was instituted after animal tests were not positive by pharmaceutical and industrial chemical (mainly pesticide) manufacturers. GLP is a quality system concerned with the organisational processing process and conditions under which non-clinical health and environmental safety studies are planned, performed, monitored, recorded, archived and reported. The primary products of any laboratory concerned with chemical analysis are the analytical data reported for specimens examined by that laboratory. Quality assurance (QA) for such a laboratory includes all of the activities associated with insuring that chemical and physical measurements are made properly, interpreted correctly and reported with appropriate estimates of error and confidence levels. QA activities also include those maintaining appropriate records of specimen/sample origins and history (sample tracking), as well as procedures, raw data and results associated with each specimen/sample. The laboratory’s personnel should be trained on safe hygienic practices like hand washing, wearing protective clothing, gloves and eye protection. Laboratories are classified into four levels of biosafety laboratories. Every laboratory should ascertain to which category they belong to and take appropriate steps to protect the laboratory. The laboratory waste also should be properly segregated according to the biomedical waste rules and should be disposed as per the existing law.
KeywordsStandard Operating Procedure Good Laboratory Practice VICH Guideline Seronegative Animal Primary Vaccination Series
- Myers JP, Vom Saal FS, Akingbemi BT, Arizono K, Belcher S, Colborn T et al (2009) Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A. Environ Health Perspect 117:309–315Google Scholar
- OECD (1998) OECD principles of good laboratory practice (as revised in 1997). OECD Environmental Health and Safety Publications (OECD) Env/Mc/chem(98)17Google Scholar
- Schneider K (1983) Faking it: the case against industrial bio-test laboratories. Amic J (Natural Resources Defence Council) 4((Spring)):14–26Google Scholar
- Tyl RW (2009) Basic exploratory research versus guideline-compliant studies used for hazard evaluation and risk assessment: bisphenol A as a case study. Environ Health Perspect (NIEHS) 117(11):1644–1651Google Scholar