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Medical Treatment for GERD in Asia

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The Rise of Acid Reflux in Asia

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Abstract

Evidence shows that gastroesophageal reflux disease (GERD) is rapidly rising in Asia. Recent globalization of economies and the associated lifestyle changes may have tipped the balance in favor of the development of GERD. Medical treatment consisting of lifestyle and dietary modifications and pharmacologic therapy are the mainstays of treatment. Only elevation of the head of the bed, left lateral decubitus positioning, and weight loss have been associated with GERD improvement. There is insufficient evidence to support restriction of alcohol, tobacco, caffeine, spicy foods, chocolate, citrus, and carbonated drinks. Avoidance of these may help with GERD symptoms. Acid suppression therapy with PPI is still the cornerstone of pharmacologic treatment of erosive esophagitis, NERD, and extraesophageal symptoms of GERD. Adjunctive treatment with H2 antagonists, antacids, alginates, and prokinetics may be used in GERD patients refractory to PPI.

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References

  1. Kaltenbach T, Crockett S, Gerson LB. Are lifestyle measures effective in patients with gastroesophageal reflux disease? An evidence-based approach. Arch Intern Med. 2006;166:65–71.

    Article  Google Scholar 

  2. Stanciu C, Bennett JR. Effects of posture on gastro-oesophageal reflux. Digestion. 1977;15:104–9.

    Article  CAS  PubMed  Google Scholar 

  3. Hamilton JW, Boisen RJ, Yamamoto DT, Wagner JL, Reichelderfer M. Sleeping on a wedge diminishes exposure of the esophagus to refluxed acid. Dig Dis Sci. 1988;33(5):518–22.

    Article  CAS  PubMed  Google Scholar 

  4. Pollmann H, Zillessen E, Pohl J, Rosemeyer D, Abucar A, Armbrecht U, et al. Effect of elevated head position in bed in therapy of gastroesophageal reflux. Z Gastroenterol. 1996;34(Suppl 2):93–9.

    PubMed  Google Scholar 

  5. Jacobson BC, Somers SC, Fuchs CS, Kelly CP, Camargo CA Jr. Body-mass index and symptoms of gastroesophageal reflux in women. N Engl J Med. 2006;354(22):2340–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Huseini M, Wood GC, Seiler J, Argyropoulos G, Irving BA, Gerhard GS, et al. Gastrointestinal symptoms in morbid obesity. Front Med (Lausanne). 2014;1:49.

    Google Scholar 

  7. Fraser-Moodie CA, Norton B, Gornall C, Magnago S, Weale AR, Holmes GK. Weight loss has an independent beneficial effect on symptoms of gastro-oesophageal reflux in patients who are overweight. Scand J Gastroenterol. 1999;34(4):337–40.

    Article  CAS  PubMed  Google Scholar 

  8. Mathus-Vliegen LM, Tytgat GN. Twenty-four-hour pH measurements in morbid obesity: effects of massive overweight, weight loss and gastric distension. Eur J Gastroenterol Hepatol. 1996;8:635–40.

    CAS  PubMed  Google Scholar 

  9. El-Hadi M, Birch DW, Gill RS, Karmali S. The effect of bariatric surgery on gastroesophageal reflux disease. Can J Surg. 2014;57(2):139–44.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Moazzez R, Bartlett D, Anggiansah A. The effect of chewing sugar-free gum on gastro- esophageal reflux. J Dent Res. 2005 Nov;84(11):1062–5.

    Article  CAS  PubMed  Google Scholar 

  11. Eherer A. Management of gastroesophageal reflux disease: lifestyle modification and alternative approaches. Dig Dis. 2014;32(1–2):149–51. Epub 2014 Feb 28

    Article  PubMed  Google Scholar 

  12. Hunt R. Acid suppression for reflux disease: “off-the-peg” or a tailored approach? Clin Gastroenterol Hepeatol. 2012;10:210.

    Article  Google Scholar 

  13. Gill SK, O’Brien L, Einarson TR, Koren G. The safety of proton pump inhibitors (PPIs) in pregnancy: a meta-analysis. Am J Gastroenterol. 2009;104:1541.

    Article  CAS  PubMed  Google Scholar 

  14. Ip S, Chung M, Moorthy D, Yu WW, Lee J, Chan JA, et al. Comparative effectiveness of management strategies for gastroesophageal reflux disease: update. Rockville: Agency for Healthcare Research and Quality (US); 2011. Report No. 11-EHC049-EF

    Google Scholar 

  15. Behm BW, Peura DA. Dexlansoprazole MR for the management of gastroesophageal reflux disease. Expert Rev Gastroenterol Hepatol. 2011;5(4):439–45.

    Article  CAS  PubMed  Google Scholar 

  16. De Giorgi F, Savarese MF, Atteo E, Leone CA, Cuomo R. Medical treatment of gastro-oesophageal reflux disease. Acta Otorhinolaryngol Ital. 2006;26(5):276–80.

    PubMed  PubMed Central  Google Scholar 

  17. Wolfe MM, Sachs G. Acid suppression; optimizing therapy for gastroduodenal ulcer healing, gastroesophageal reflux disease, and stress-related erosive syndrome. Gastroenterology. 2000;118:S9.

    Article  CAS  PubMed  Google Scholar 

  18. Tytgat GN, Nio CY. The medical therapy of reflux oesophagitis. Baillieres Clin Gastroenterol. 1987;1(4):791–807.

    Article  CAS  PubMed  Google Scholar 

  19. Fock KM, Talley NJ, Fass R, Goh KL, Katelaris P, Hunt R, et al. Asia-Pacific consensus on the management of gastroesophageal reflux disease: update. Gastroenterol Hepatol. 2008;23:8–22.

    Article  Google Scholar 

  20. Sontag SJ. The medical management of reflux esophagitis. Role of antacids and acid inhibition. Gastroenterol Clin North Am. 1990;19:683.

    CAS  PubMed  Google Scholar 

  21. Chiu CT, Hsu CM, Wang CC, Chang JJ, Sung CM, Lin CJ, et al. Randomised clinical trial: sodium alginate oral suspension is non-inferior to omeprazole in the treatment of patients with non-erosive gastroesophageal disease. Aliment Pharmacol Ther. 2013;38(9):1054–64.

    Article  CAS  PubMed  Google Scholar 

  22. Thomas E, Wade A, Crawford G, Jenner B, Levinson N, Wilkinson J. Randomised clinical trial: relief of upper gastrointestinal symptoms by an acid pocket-targeting alginate-antacid (Gaviscon double action) – a double-blind, placebo-controlled, pilot study in gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2014;39(6):595–602. Epub 2014 Jan 28

    Article  CAS  PubMed  Google Scholar 

  23. De Ruigh A, Roman S, Chen J, Pandolfino JE, Kahrilas PJ. Gaviscon double action liquid (antacid & alginate) is more effective than antacid in controlling post-prandial oesophageal acid exposure in GERD patients: a double-blind crossover study. Aliment Pharmacol Ther. 2014;40(5):531–7. Epub 2014 Jul 10

    PubMed  PubMed Central  Google Scholar 

  24. Ren LH, Chen WX, Qian LJ, Li S, Gu M, Shi RH. Addition of prokinetics to PPI therapy in gastroesophageal reflux disease: a meta-analysis. World J Gastroenterol. 2014;20(9):2412–9.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Champion MC. Prokinetic therapy in gastroesophageal reflux disease. Can J Gastroenterol. 1997;11(Suppl B):55B–65B.

    PubMed  Google Scholar 

  26. Van Noord C, Dieleman JP, van Herpen G, Verhamme K, Sturkenboom MC. Domperidone and ventricular arrhythmia or sudden cardiac death: a population-based case-control study in the Netherlands. Drug Saf. 2010;33(11):1003–14.

    Article  PubMed  Google Scholar 

  27. Katz PO, Gerson LB, Vela MF. Diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108:308–28.

    Article  PubMed  Google Scholar 

  28. Liu Q, Feng CC, Wang EM, Yan XJ, Chen SL. Efficacy of mosapride plus proton pump inhibitors for treatment of gastroesophageal reflux disease: a systematic review. World J Gastroenterol. 2013;19(47):9111–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Tominaga K, Iwakiri R, Fujimoto K, Fujiwara Y, Tanaka M, Shimoyama Y, et al. Rikkunshito improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan. J Gastroenterol. 2012;47(3):284–92.

    Article  CAS  PubMed  Google Scholar 

  30. Yamane Y, Yamaguchi T, Tsumori M, Yamauchi M, Yano S, Yamamoto M, et al. Elcatonin is effective for lower back pain and the symptoms of gastroesophageal reflux disease in elderly osteoporotic patients with kyphosis. Geriatr Gerontol Int. 2011;11:215–20.

    Article  PubMed  Google Scholar 

  31. Dean B, Gano A Jr, Knight K, Ofman J, Fass R. Effectiveness of proton pump inhibitors in non-erosive reflux disease. Clin Gastroenterol Hepatol. 2004;2:654–64.

    Article  Google Scholar 

  32. Ponce J, Arguello L, Bastida G, Ponce M, Ortiz V, Garrigues V. On-demand therapy with rabeprazole in nonerosive and erosive gastroesophageal reflux disease in clinical practice: effectiveness, health-related quality of life, and patient satisfaction. Dig Dis Sci. 2004;49:931–6.

    Article  CAS  PubMed  Google Scholar 

  33. Hughes D, Bodger K, Bytzer P, de Herdt D, Dubois D. Economic analysis of on-demand maintenance therapy with proton pump inhibitors in patients with non-erosive reflux disease. Pharmaeconomics. 2005;23:1031–41.

    Article  CAS  Google Scholar 

  34. Wu JC, Chan FK, Ching JY, Leung WK, Lee YT, Sung JJ. Empirical treatment based on “typical” reflux symptoms is inappropriate in a population with a high prevalence of helicobacter pylori infection. Gastrointest Endosc. 2002;55(4):461–5.

    Article  PubMed  Google Scholar 

  35. Richter JE, Sabesin SM, Kogut DG, Kerr RM, Wruble LD, Collen MJ. Omeprazole versus ranitidine or ranitidine/metoclopramide in poorly responsive symptomatic gastroesophageal reflux disease. Am J Gastroenterol. 1996;91(9):1766–72.

    CAS  PubMed  Google Scholar 

  36. Kiljander TO, Junghard O, Beckman O, Lind T. Effect of esomeprazole 40 mg once or twice daily on asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med. 2010;181(10):1042–8.

    Article  PubMed  Google Scholar 

  37. Harding SM, Sontag SJ. Asthma and gastroesophageal reflux. Am J Gastroenterol. 2000;95:S23–32.

    Article  CAS  PubMed  Google Scholar 

  38. Chan WW, Chiou E, Obstein KL, Tignor AS, Whitlock TL. The efficacy of proton pump inhibitors for the treatment of asthma in adults: a meta-analysis. Arch Intern Med. 2011;171(7):620–9.

    Article  CAS  PubMed  Google Scholar 

  39. Qadeer MA, Phillips CO, Lopez AR, Steward DL, Noordzij JP, Wo JM, et al. Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials. Am J Gastroenterol. 2006;101(11):2646–54.

    Article  CAS  PubMed  Google Scholar 

  40. Park W, Hicks D, Khandwala F, Richter JE, Abelson T, Milstein C, et al. Laryngeal reflux: prospective cohort study evaluating optimal dose of proton-pump inhibitor therapy and pretherapy predictors of response. Laryngoscope. 2005;115(7):1230–8.

    Article  CAS  PubMed  Google Scholar 

  41. Spechler SJ, Lee E, Ahnen D, Goyal RK, Hirano I, Ramirez F, et al. Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease: follow-up of a randomized controlled trial. JAMA. 2001;285(18):2331–8.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Kurokawa General Hospital, Tohoku University, 60 Nishi-Hinoki, Yoshioka, Kurokawa, Miyagi, 981-3682, Japan

    Michio Hongo

  2. Gastroenterologist and Specialized Advanced Therapeutic Endoscopist, Aquinas University Hospital Foundation Inc, Legazpi City, Albay, Philippines

    Julius Carlo R. Rustia

Authors
  1. Michio Hongo
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  2. Julius Carlo R. Rustia
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Correspondence to Michio Hongo .

Editor information

Editors and Affiliations

  1. University of Kansas School of Medicine, VA Medical Center, Kansas city, MO, USA

    Prateek Sharma

  2. Gastroenterology, KEM Hospital, Mumbai, Maharashtra, India

    Shobna Bhatia

  3. University of Malaya, Kuala Lumpur, Malaysia

    Khean Lee Goh

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Hongo, M., Rustia, J.C.R. (2018). Medical Treatment for GERD in Asia. In: Sharma, P., Bhatia, S., Goh, K. (eds) The Rise of Acid Reflux in Asia. Springer, New Delhi. https://doi.org/10.1007/978-81-322-0846-4_7

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  • DOI: https://doi.org/10.1007/978-81-322-0846-4_7

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  • Publisher Name: Springer, New Delhi

  • Print ISBN: 978-81-322-0845-7

  • Online ISBN: 978-81-322-0846-4

  • eBook Packages: MedicineMedicine (R0)

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