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Reasons for the Rise of Gastroesophageal Reflux Disease in Asia

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The Rise of Acid Reflux in Asia

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Abstract

Gastroesophageal reflux disease (GERD) was considered an uncommon disease in Asia in the past but is now a rapidly emerging disease. Various factors underlie this rise, which can be broadly divided into environmental and host genetic factors. Among these factors, the rapid increase in overweight and obesity in the region is probably the most important. Other factors include lifestyle changes which have accompanied “Westernization” of the Asian population, including a change in diet, smoking, alcohol consumption, and physical activity, but these are often hard to measure. A decline in Helicobacter pylori infection across the region likely plays an important role as well. Ethnic differences and differences in the rate of rise of GERD between ethnic groups in the region point to a key role for host genetic factors. Genetic polymorphisms which involve the interleukin-1B gene have been reported, but more work needs to be done in this area.

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  1. University of Malaya, Kuala Lumpur, Malaysia

    Khean Lee Goh

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  1. University of Kansas School of Medicine, VA Medical Center, Kansas city, MO, USA

    Prateek Sharma

  2. Gastroenterology, KEM Hospital, Mumbai, Maharashtra, India

    Shobna Bhatia

  3. University of Malaya, Kuala Lumpur, Malaysia

    Khean Lee Goh

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Goh, K.L. (2018). Reasons for the Rise of Gastroesophageal Reflux Disease in Asia. In: Sharma, P., Bhatia, S., Goh, K. (eds) The Rise of Acid Reflux in Asia. Springer, New Delhi. https://doi.org/10.1007/978-81-322-0846-4_3

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