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Mass Spectroscopy: Herbal Drugs and Fingerprints

  • Devi Datt Joshi
Chapter

Abstract

The cultivation and wild collection of different accessions of a medicinal plant species from the different regions of the world may differ for the amounts of marker compounds. The MS fingerprints are based on m/z value of molecule, helps to establish the probable structure of compound. Analysis of herbals by MS highlights key signal patterns that characterize the individual species/chemo-type and provide information about quality, which exists at a certain location and adulterant, if any. The therapeutic components present in the herbals, its isolate, and metabolites are determined and quantified with LC–MS, GC–MS, and LC–MS/MS.

Keywords

Glycyrrhizae Radix Botanical Product Angelicae Sinensis Radix Scutellariae Radix Echinacea Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Gaskell SJ. Electrospray: principles and practice. J Mass Spectrom. 1997;32:677–88.CrossRefGoogle Scholar
  2. 2.
    Wang Y, Yang L, He Y, Wang H, Welbeck EW, Annie Bligh SW, Wang Z. Characterization of fifty-one flavonoids in a Chinese herbal prescription longdan xiegan decoction by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry and photodiode array detection. Rapid Commun Mass Spectrom. 2008;22:1767–78.PubMedCrossRefGoogle Scholar
  3. 3.
    Correia H, González-Paramás A, Amaral MT, Santos-Buelga C, Batista MT. Characterisation of polyphenols by HPLC-PADESI/MS and antioxidant activity in Equisetum telmateia. Phytochem Anal. 2005;16:380–7.PubMedCrossRefGoogle Scholar
  4. 4.
    Hillenkamp F, Karas M, Beavis RC, Chait BT. Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers. Anal Chem. 1991;63:1193.CrossRefGoogle Scholar
  5. 5.
    Greene LA, Issa I, Gray DE, Schwartz SA. Streamlining plant sample preparation: the use of high-throughput robotics to process Echinacea samples for biomarker profiling by MALDI-TOF mass spectrometry. J Biomol Tech. 2007;18(4):238–44.PubMedGoogle Scholar
  6. 6.
    Kooy FV, Maltese C, Cho YH, Kim HK, Verpoorte R. Quality control of herbal material and phytopharmaceuticals with MS and NMR based metabolic fingerprinting. Planta Med. 2009;75:763–75.PubMedCrossRefGoogle Scholar
  7. 7.
    Patil PS, Shettigar R. An advancement of analytical techniques in herbal research. J Adv Sci Res. 2010;1(1):8–14.Google Scholar

Bibliography

  1. Chen XJ, Ji H, Zhang QW, Tu PF, Wang YT, Guo BL, Li SP. A rapid method for simultaneous determination of 15 flavonoids in epimedium using pressurized liquid extraction and ultra-performance liquid chromatography. J Pharm Biomed Anal. 2008;46:226–35.PubMedCrossRefGoogle Scholar
  2. Dunn BW. Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes. Phys Biol. 2008;5:1–24.CrossRefGoogle Scholar
  3. Grata E, Boccard J, Guillarme D, Glauser G, Carrupt PA, Farmer EE, Wolfender J-L, Rudaz S. UPLC‑TOF‑MS for plant metabolomics: a sequential approach for wound marker analysis in Arabidopsis thaliana. J Chromatogr B. 2008;871:261–70.CrossRefGoogle Scholar
  4. Ho HM, Chen R, Huang Y, Chen ZY. Vascular effects of a soy leaves (Glycine max) extract and kaempferol glycosides in isolated rat carotid arteries. Planta Med. 2002;68:487–91.PubMedCrossRefGoogle Scholar
  5. Hope JL, Prazen BJ, Nilsson EJ, Jack RM, Synovec RE. Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry detection: analysis of amino acid and organic acid trimethylsilyl derivatives, with application to the analysis of metabolites in rye grass samples. Talanta. 2005;65:380–8.PubMedCrossRefGoogle Scholar
  6. Kang J, Zhou L, Sun J, Han J, Guo DA. Chromatographic fingerprint analysis and characterization of furocoumarins in the roots of angelica dahurica by HPLC/DAD/ESI‑MSn technique. J Pharm Biomed Anal. 2008;47:778–85.PubMedCrossRefGoogle Scholar
  7. Seger C, Sturm S. Analytical aspects of plant metabolic profiling platforms: current standings and future aims. J Proteome Res. 2007;6:480–97.PubMedCrossRefGoogle Scholar
  8. Shin MH, Hong MK, Kim WS, Lee YJ, Jeoung YC. Identification of a new analogue of sildenafil added illegally to a functional food marketed for penile erectile dysfunction. Food Addit Contam. 2003;20:793–6.PubMedCrossRefGoogle Scholar
  9. Thiocone A, Farmer EE, Wolfender JL. Screening for wound-induced oxylipins in Arabidopsis thaliana by differential HPLC-APCI/MS profiling of crude leaf extracts and subsequent characterisation by capillary- scale NMR. Phytochem Anal. 2008;19:198–205.PubMedCrossRefGoogle Scholar
  10. Zhong DF, Xing J, Zhang SQ, Sun L. Study of the electrospray ionization tandem mass spectrometry of sildenafil derivatives. Rapid Commun Mass Spectrom. 2002;16:1836–43.PubMedCrossRefGoogle Scholar

Copyright information

© Springer India 2012

Authors and Affiliations

  1. 1.Amity Institute of Phytochemistry & PhytomedicineAmity University, Uttar PradeshNoidaIndia

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