Laboratory Models Developed

  • Mahesh Chandra Agrawal


Globally, schistosomiasis is identified as an important disease of human beings, only next to malaria. Not so long ago, there was no effective drug to cure the disease thereby necessitating to undertake drug trials in different experimental models using different drug molecules—some available in minuscule quantities. Still, immunopathology of schistosomiasis is less understood, and different models are needed to know complexities of this branch of biology. Among three well-known human schistosomes, Schistosoma mansoni is used most extensively as laboratory model, being widely distributed and easiness by which it is maintained in the laboratory.


Buffalo Calf Male Worm Schistosome Species Blood Fluke Adult Fluke 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Achuthan HN, Alwar VS (1973) A note on the occurrence of nasal schistosomiasis in sheep and goats in Tamil Nadu. Indian Vet J 50:1058–1059Google Scholar
  2. Agrawal MC (1978) Studies on the heterologous immunity in schistosomiasis. PhD thesis, Jawaharlal Nehru Krishi Vishwa Vidyalaya, JabalpurGoogle Scholar
  3. Agrawal MC (1985) Final report on “Zoonotic potentials, zooprophylaxis, serodiagnosis and quick identification of cercariae of some mammalian schistosomes of Indian origin”. Indian Council of Medical Research, New DelhiGoogle Scholar
  4. Agrawal MC (1996a) Habitat of Schistosoma nasale in the final host. Global meet on parasitic diseases, New Delhi, 18–22nd Mar 1996, Abstract No. pp 8, p 141Google Scholar
  5. Agrawal MC (1996b) Rabbit as a model for Schistosomiasis nasale. J Parasitol Appl Biol 5:25–27Google Scholar
  6. Agrawal MC, Mishra A (1994) Evaluation of host susceptibility against schistosome infection. Indian J Parasitol 18:229–230Google Scholar
  7. Agrawal MC, Mishra A (1996) Comparative susceptibility of guinea pig to Schistosoma spindale. Indian Vet J 73:131–133Google Scholar
  8. Agrawal MC, Tewari A (1999) Size differences in the adult Schistosoma spindale according to host compatibility. Indian Vet J 76:171–173Google Scholar
  9. Agrawal MC, Panesar N, Shah HL (1984) Effect of dry season on sex of recovered schistosomes from experimental animals. Indian J Anim Health 23:103–104Google Scholar
  10. Agrawal MC, Panesar N, Das M (1985) Patent infection with Schistosoma incognitum to white mouse (Mus musculus). Curr Sci 54:640–641Google Scholar
  11. Agrawal MC, Panesar N, Shah HL (1986) Diagnosis of experimental schistosomiasis in dogs. Indian Vet J 63:276–280Google Scholar
  12. Agrawal MC, Sano M, Mishra A, Solanki PK (1992) Chemotherapeutic trials with praziquantel against Schistosoma incognitum and Hymenolepis spp. in rats. Indian Vet J 69:279–280Google Scholar
  13. Agrawal MC, George J, Gupta S (1999) Chemotherapeutic trails using Schistosoma incognitum mouse model. J Parasitic Dis 23:137–138Google Scholar
  14. Agrawal MC, Jain J, Rao KNP (2001) Sudden death of piglets during immature schistosome infection. Indian J Anim Sci 71:681–682Google Scholar
  15. Ahluwalia SS (1968) Studies on host parasite relationship and control of Schistosoma incognitum infection of domestic pig with observations on the zoonotic potentialities of the parasite. PhD thesis, Agra University, AgraGoogle Scholar
  16. Ahluwalia SS (1972a) Experimental Schistosomiasis incognitum in pigs. Indian J Anim Sci 42:723–729Google Scholar
  17. Ahluwalia SS (1972b) Zoonotic potentials of Schistosoma incognitum. Indian J Anim Sci 42:962–964Google Scholar
  18. Anandan R (1985) Studies on Schistosoma nasale Rao 1933 (Trematoda-Schistosomatidae). PhD thesis, Tamil Nadu Agricultural University, CoimbatoreGoogle Scholar
  19. Anandan R, Raja EE (1987) Preliminary trials with praziquantel in Schistosoma nasale infection in sheep and goat. Indian Vet J 64:108–110Google Scholar
  20. Bhilegaonkar NG (1981) Studies on the immunity against Schistosoma incognitum in mice by using in vitro derived gamma irradiated schistosomulae. PhD thesis, Jawaharlal Nehru Krishi Vishwa Vidyalaya, JabalpurGoogle Scholar
  21. Biswas G (1975) Relative susceptibility of mammals to infection with Schistosoma incognitum. Indian J Anim Health 14:179–181Google Scholar
  22. Biswas G, Subramanian G (1990) Experimental infection of common laboratory animals with Schistosoma nasale, a parasite of bovines. Indian J Anim Sci 60:149–150Google Scholar
  23. Borkakoty MR (1975) Studies on immunization of albino mice against Schistosoma incognitum. MVSc thesis, Jawaharlal Nehru Krishi Vishwa Vidyalaya, JabalpurGoogle Scholar
  24. Das M, Agrawal MC (1986) Experimental infection of rhesus monkeys with Schistosoma incognitum and Orientobilharzia dattai. Vet Parasitol 22:151–154PubMedCrossRefGoogle Scholar
  25. Dhanda I (1956) Infestation with ova morphologically resembling Schistosoma haematobium. J Indian Med Assoc 26:407–408PubMedGoogle Scholar
  26. Dutt SC (1957) Development of female Schistosoma spindale in guinea pig. Nature 179:1359PubMedCrossRefGoogle Scholar
  27. Dutt SC (1962) Studies on the susceptibility of the guinea pig to infection with Schistosoma spindale Montgomery 1906. Parasitology 52:199–206CrossRefGoogle Scholar
  28. Dutt SC (1967) Susceptibility of Macaca mulatta to Schistosoma incognitum with observations on pathology of the infection. Indian J Med Res 55:1173–1180PubMedGoogle Scholar
  29. Dutt SC, Srivastava HD (1955) A revision of genus Ornithobilharzia, Odhner 1912 (Trematoda: Schistosomatidae). In: Proceedings of the 42nd Indian Science Congress. Part III, p 283Google Scholar
  30. Dutt SC, Srivastava HD (1962) Biological studies on Orientobilharzia dattai (Dutt and Srivastava 1952) Dutt and Srivastava 1955–A Blood–fluke of ruminants. Indian J Vet Sci 32:216–228Google Scholar
  31. Dutt SC, Srivastava HD (1964) Studies on the life history of Orientobilharzia turkestanicum (Skrjabin, 1913) Dutt and Srivastava, 1955(Preliminary report). Curr Sci 24:752–753Google Scholar
  32. Dutt SC, Srivastava HD (1968) Studies on Schistosoma nasale Rao 1933. II Molluscan and mammalian hosts of the blood-fluke. Indian J Vet Sci Anim Husb 38:210–216Google Scholar
  33. Fairley NH, Mackie FP, Jasudasan F (1930) Studies on Schistosoma spindale. Part V The guinea pig as a host for male schistosomes. Indian J Med Res Mem 17:61–62Google Scholar
  34. Gadgil RK (1963) Human schistosomiasis in India. Indian J Med Res 51:244–251PubMedGoogle Scholar
  35. Gupta S (2002) Clinical, biochemical and parasitological studies and prevalence of caprine schistosomiasis in and around Jabalpur. PhD thesis, Rani Durgavati Vishwa Vidyalaya, JabalpurGoogle Scholar
  36. Jain J, Agrawal MC, Rao KNP (2000) Effect of praziquantel and closantel treatment on haematology and faecal egg count in experimental porcine schistosomiasis. Indian J Anim Sci 70:823–825Google Scholar
  37. Kohli S, Agrawal MC (1995) Differentiation of mammalian schistosome cercariae on basis of their furcal tip. Indian J Anim Sci 65:41–43Google Scholar
  38. Koshy TJ, Achuthan HN, Alwar VS (1975) Cross transmissibility of Schistosoma nasale Rao, 1933 infection between cattle and buffaloes. Indian Vet J 52:216–218Google Scholar
  39. Kruatrachue M, Bhaibulaya M, Harinasuta C (1965) Orientobilharzia harnasutai sp. nov., a mammalian blood-fluke, its morphology and life cycle. Ann Trop Med Parasitol 59:181–188PubMedGoogle Scholar
  40. Liston WG, Soparkar MB (1918) Bilharziasis among animals in India: the life cycle of Schistosoma spindalis. Indian J Med Res 5:567–569Google Scholar
  41. Mishra A (1991) Development of Schistosoma spindale and S. indicum in the laboratory and their diagnosis in final host. PhD thesis, Rani Durgavati University, JabalpurGoogle Scholar
  42. Mishra A, Agrawal MC (1993) Development of Schistosoma spindale in albino mouse (Mus musculus). J Vet Parasitol 7:545–550Google Scholar
  43. Mishra A, Agrawal MC (1994a) Maintenance of Schistosoma spindale in rabbits in laboratory. Indian J Anim Sci 64:352–354Google Scholar
  44. Mishra A, Agrawal MC (1994b) Susceptibility of albino rats to Schistosoma spindale. Indian J Parasitol 18:99–102Google Scholar
  45. Mudaliar SV, Ramanujachari G (1945) Schistosoma nairi n. sp. from an elephant. Indian Vet J 22:1–4Google Scholar
  46. Muraleedharan K, Kumar SP, Hegde KS, Alwar VS (1973) Incidence of Schistosoma nasale, Rao, 1933 infection in sheep. Indian Vet J 50:1056–1057Google Scholar
  47. Muraleedharan K, Seshadri SJ, Babu J, Kumar SP, Hegde KS, Alwar VS (1976) Experimental infection of buffalo calves with the cercariae of Schistosoma nasale, Rao 1933 of cattle origin and a study of lesions encountered. Mysore J Agric Sci 10:673–680Google Scholar
  48. Nikhale SG (1972) Studies on experimental Schistosoma incognitum infection in albino mice with particular reference to its immunology. MVSc thesis, Jawaharlal Nehru Krishi Vishwa Vidyalaya, JabalpurGoogle Scholar
  49. Panesar N, Agrawal MC (1986) Comparative efficacy of faecal examination and serological methods in experimental schistosomiasis in mouse. Indian J Med Res 84:366–373PubMedGoogle Scholar
  50. Panesar N, Agrawal MC, Arora S, Shah HL (1986) Evaluation of diagnostic techniques in experimental Schistosomiasis incognitum infection in rabbits. Indian Vet J 63:799–803Google Scholar
  51. Rajamohanan K, Peter CT (1972) Studies on nasal schistosomiasis in cattle and buffaloes. Indian Vet J 49:1063–1065Google Scholar
  52. RajKhowa C (1989) Studies on schistosomiasis in domestic animals in Assam with special reference to Schistosoma indicum. PhD thesis, Assam Agricultural University, GuwahatiGoogle Scholar
  53. Rao MAN (1934) A comparative study of Schistosoma spindalis Montgomery 1906 and Schistosoma nasalis n. sp. Indian J Vet Sci Anim Husb 4:1–28Google Scholar
  54. Rao MAN (1937) A preliminary report on canine schistosomiasis in the Madras Presidency. Indian J Vet Sci Anim Husb 7:109–112Google Scholar
  55. Sahay MN, Sahai BN (1978) Studies on the susceptibility of the laboratory animals, kids, and lambs to experimental infection with Schistosoma nasale Rao 1933. J Parasitol 64:1135–1136CrossRefGoogle Scholar
  56. Sapate PP, Bhilegaonkar NG, Maske DK (2001) Development of Schistosoma nasale in hamster and Mastomys and their pathogenicity. Indian Vet J 78:14–17Google Scholar
  57. Shames N, Agrawal MC, Rao KNP (2000) Chemotherapeutic efficacy of praziquantel and closantel in experimental porcine schistosomiasis. Indian J Anim Sci 70:797–800Google Scholar
  58. Shrivastava HOP (1977) Studies on immunity to Schistosoma incognitum using irradiated cercariae, worm homogenate and excretions and secretions of the adult fluke. PhD thesis, Jawaharlal Nehru Krishi Vishwa Vidyalaya, JabalpurGoogle Scholar
  59. Shrivastava MK, Agrawal MC (1999) Effect of triclabendazole and oxyclozanide on Schistosoma incognitum infection in mouse. Indian Vet J 76:493–496Google Scholar
  60. Singh BP, Ahluwalia SS (1977a) Efficacy of Neguvon (Bayer) against Orientobilharzia dattai in sheep, goat and white mice. Indian Vet J 54:859–861Google Scholar
  61. Singh BP, Ahluwalia SS (1977b) Post-cercarial development of Orientobilharzia dattai (Trematoda: Schistosomatidae). Indian Vet J 54:207–212Google Scholar
  62. Sinha PK, Srivastava HD (1965) Studies on Schistosoma incognitum, Chandler 1926 III on the host specificity of blood-fluke. Indian Vet J 42:335–341PubMedGoogle Scholar
  63. Srivastava HD (1942) Whip worm and blood-flukes in dogs in India with remarks on trichuriasis. Parasitology 34:122–123CrossRefGoogle Scholar
  64. Srivastava HD, Dutt SC (1962) Studies on Schistosoma indicum. Technical research series No 34, ICAR, New DelhiGoogle Scholar
  65. Srivastava HD, Muralidharam SRG, Dutt SC (1964) Pathogenicity of experimental infection of Schistosoma indicum Montgomery (1906) to young sheep. Indian J Vet Sci 34:35–40Google Scholar
  66. Thakre MD (1996) Studies on experimental infection of Schistosoma nasale in goats. MVSc thesis, Panjabrao Deshmukh Krishi Vidyapeeth, Akola, MaharashtraGoogle Scholar
  67. Varma TK, Singh BP, Tewari HC (1983) Immunity to Schistosoma incognitum in mice by previous exposure to S. spindale. J Helminthol 57:37–38PubMedCrossRefGoogle Scholar

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© Springer India 2012

Authors and Affiliations

  • Mahesh Chandra Agrawal
    • 1
  1. 1.Veterinary CollegeJabalpurIndia

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