Weaning from mechanical ventilation means the transition from total ventilatory support to spontaneous breathing. It is usually a rapid and smooth process in most of the patients however this can become a progressive and prolonged process in 20–25% of the cases. These patients require a systematic approach for successful liberation from the ventilator. It should be started early once the patients fulfils the criteria for weaning. This weaning has two components: liberation from the ventilator and extubation.