Mechanical Ventilation in Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is characterized by a brief precipitating event followed by rapidly developing dyspnea. These patients have markedly impaired respiratory system compliance and reduced aerated lung volume. The hypoxemia is refractory to low fraction of oxygen concentration and low positive end expiratory pressure (PEEP). The mortality from ARDS is around 35–40%. Current therapy of acute lung injury (ALI) and ARDS revolves around treatment of underlying cause, lung protective ventilatory strategy, and appropriate fluid management.