Skip to main content
SpringerLink
Log in
Book cover

Moyamoya Disease Update pp 287–293Cite as

Overview: Issues in Young Children and Adults

  • Chapter

  • 986 Accesses

Abstract

Moyamoya disease is a chronic, occlusive cerebrovascular disease with unknown etiology which has two peaks in age distribution, a first peak in children and the second peak in young adults [1]. The most recent epidemiological national survey in Japan estimates that the annual number of the patients with moyamoya disease is 7,700 with the incidence rate of 5.4 per million populations, with the female/male ratio of 1.8:1 [2]. The peaks in age distribution of moyamoya disease consist of a first peak in children and the second peak in young adults. The incidence of patients with family history was 12.1% among definitive moyamoya patients [2]. In this chapter, the authors seek to overview the characteristics of moyamoya disease in children and young adults.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Suzuki J, Takaku A (1969) Cerebrovascular ‘moyamoya’ disease. Disease showing abnormal net-like vessels in base of brain. Arch Neurol 20:288–299

    CAS  Google Scholar 

  2. Kuriyama S, Kusaka Y, Fujimura M, et al. (2008) Prevalence and clinicoepidemiological features of moyamoya disease in Japan: findings from a nationwide epidemiological survey. Stroke 39:42–47

    Article  PubMed  Google Scholar 

  3. Ikeda H, Sasaki T, Yoshimoto T, et al. (1999) Mapping of a familial moyamoya disease gene to chromosome 3q24-p26. Am J Hum Genet 64:533–537

    Article  PubMed  CAS  Google Scholar 

  4. Sakurai K, Horiuchi Y, Ikeda H, et al. (2004) A novel susceptibility locus for moyamoya disease on chromosome 8q23. J Hum Genet 49:278–281

    Article  PubMed  CAS  Google Scholar 

  5. Yamaguchi T, Tada M, Houkin K, et al. (2000) Linkage of familial moyamoya disease to chromosome 17q25. Stroke 31:930–935

    Article  Google Scholar 

  6. Mineharu Y, Liu W, Inoue K, et al. (2008) Autosomal dominant moyamoya disease maps to chromosome 17q25.3. Neurology 70:2357–2363

    Article  PubMed  CAS  Google Scholar 

  7. Oka K, Yamashita M, Sadoshima S, et al. (1981) Cerebral hemorrhage in moyamoya disease at autopsy. Virchows Arch Pathol Anat Histol 392:247–261

    Article  CAS  Google Scholar 

  8. Oki K, Suzuki N (2007) In: Hashimoto N (ed) Report by the Research Committee on Spontaneous Occlusion of the Circle of Willis (Moyamoya Disease), pp 4–5

    Google Scholar 

  9. Yoshida Y, Yoshimoto T, Shirane R, et al. (1999) Clinical course, surgical management, and long-term outcome of moyamoya patients with rebleeding after an episode of intracerebral hemorrhage: a extensive follow-up study. Stroke 30:2272–2276

    Article  PubMed  CAS  Google Scholar 

  10. Kuroda S, Hashimoto N, Yoshimoto T, et al. (2007) Radiological findings, clinical course, and outcome in asymptomatic moyamoya disease. Results of multi-center survey in Japan. Stroke 38:1430–1435

    Google Scholar 

  11. Fukui M (1997) Guidelines for the diagnosis and treatment of spontaneous occlusion of the circle of Willis (‘moyamoya disease’). Research Committee on Spontaneous Occlusion of the Circle of Willis (Moyamoya Disease) of the Ministry of Health and Welfare, Japan. Clin Neurol Neurosurg 99 Suppl 2:S238–240

    PubMed  Google Scholar 

  12. Kuroda S, Ishikawa T, Houkin K, et al. (2005) Incidence and clinical features of disease progression in adult moyamoya disease. Stroke 36:2148–2153

    Article  PubMed  Google Scholar 

  13. Ikezaki K, Matsushima T, Kuwabara Y, et al. (1994) Cerebral circulation and oxygen metabolism in childhood moyamoya disease: a perioperative positron emission tomography study. J Neurosurg 81:843–850

    Article  PubMed  CAS  Google Scholar 

  14. Saito N, Nakagawara J, Nakamura H, et al. (2004) Assessment of cerebral hemodynamics in childhood moyamoya disease using a quantitative and a semiquantitative IMP-SPECT study. Ann Nucl Med 18:323–331

    Article  PubMed  Google Scholar 

  15. Ishikawa T, Houkin K, Kamiyama H, et al. (1997) Effects of surgical revascularization on outcome of patients with pediatric moyamoya disease. Stroke 28:1170–1173

    Article  PubMed  CAS  Google Scholar 

  16. Scott RM, Smith JL, Robertson RL, et al. (2004) Long-term outcome in children with moyamoya disease after cranial revascularization by pial synangiosis. J Neurosurg 100:142–149

    PubMed  Google Scholar 

  17. Morimoto M, Iwama T, Hashimoto N, et al. (1999) Efficacy of direct revascularization in adult moyamoya disease: haemodynamic evaluation by positron emission tomography. Acta Neurochir (Wien) 141:377–384

    Article  CAS  Google Scholar 

  18. Mizoi K, Kayama T, Yoshimoto T, et al. (1996) Indirect revascularization for moyamoya disease: is there a benefical effect for adult patients? Surg Neurol 45:541–548

    Article  PubMed  CAS  Google Scholar 

  19. Miyamoto S, Japan Adult Moyamoya Trial Group. (2004) Study design for a prospective randomized trial of extracranial-intracranial bypass surgery for adults with moyamoya disease and hemor-rhagic onset: the Japan Adult Moyamoya Trial Group. Neurol Med Chir (Tokyo) 44:218–219

    Article  Google Scholar 

  20. Houkin K, Ishikawa T, Yoshimoto T, et al (1997) Direct and indirect revascularization for moyamoya disease: surgical techniques and peri-operative complications. Clin Neurol Neurosurg 99 Suppl 2:S142–145

    Article  PubMed  Google Scholar 

  21. Fujimura M, Kaneta T, Mugikura S, et al. (2007) Temporary neurologic deterioration due to cerebral hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in patients with adult-onset moyamoya disease. Surg Neurol 67:273–282

    Article  PubMed  Google Scholar 

  22. Kim JE, Oh CW, Kwon OK, et al. (2008) Transient hyperperfusion after superfisial temporal artery/ middle cerebral artery bypass surgery as a possible cause of postoperative transient neurological deterioration. Cerebrovasc Dis 25:580–586

    Article  PubMed  Google Scholar 

  23. Fujimura M, Mugikura S, Kaneta T, et al. (2009) Incidence and risk factors for symptomatic cerebral hyperperfusion following superficial temporal artery-middle cerebral artery anastomosis in patients with moyamoya disease. Surg Neurol 71:442–447

    Article  PubMed  Google Scholar 

  24. Fujimura M, Kaneta T, Shimizu H, et al. (2007) Symptomatic hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in a child with moyamoya disease. Childs Nerv Syst 23:1195–1198

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan

    Teiji Tominaga

  2. Department of Neurosurgery, Kohnan Hospital, Sendai, 982-8523, Japan

    Miki Fujimura

Authors
  1. Teiji Tominaga
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Miki Fujimura
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Teiji Tominaga .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Seoul National University College of Medicine Seoul National University Children's Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744, Republic of Korea

    Byung-Kyu Cho (Professor) (Professor)

  2. Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8578, Japan

    Teiji Tominaga (Professor, Chairman) (Professor, Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer

About this chapter

Cite this chapter

Tominaga, T., Fujimura, M. (2010). Overview: Issues in Young Children and Adults. In: Cho, BK., Tominaga, T. (eds) Moyamoya Disease Update. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99703-0_40

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-99703-0_40

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-99702-3

  • Online ISBN: 978-4-431-99703-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation