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Perfusion Imaging in Moyamoya Disease

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Moyamoya Disease Update
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Abstract

Moyamoya disease is a chronic, occlusive cerebrovascular disorder involving the distal internal carotid artery and/or the proximal portion of the anterior and middle cerebral arteries (ACAs and MCAs, respectively). Moyamoya disease is characterized by the extensive development of collateral pathways. The first pathway is known as the “basal moyamoya,” and includes an abnormal dilation of the perforating arteries and a true neoangiogenesis around the circle of Willis. Other collateral pathways may occur via pial-to-pial anastomoses from other less compromised territories, particularly the posterior circulation, or in more advanced cases, via a dural-to-pial collateral pathway, which is known as the “vault moyamoya.” These collateral networks seemingly provide an alternative route of cerebral perfusion in moyamoya disease [1–3].

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References

  1. Suzuki J, Takaku A (1969) Cerebrovascular “moyamoya” disease. Disease showing abnormal net-like vessels in base of brain. Arch Neurol 20:288–299

    Article  PubMed  CAS  Google Scholar 

  2. Scott RM, Smith ER (2009) Moyamoya disease and moyamoya syndrome. N Engl J Med 360:1226–1237

    Article  PubMed  CAS  Google Scholar 

  3. Kuroda S, Houkin K (2008) Moyamoya disease: current concepts and future perspectives. Lancet Neurol 7:1056–1066

    Article  PubMed  Google Scholar 

  4. Yoon HK, Shin HJ, Chang YW (2002) “Ivy sign” in childhood moyamoya disease: depiction on FLAIR and contrast-enhanced T1-weighted MR images. Radiology 223:384–389

    Article  PubMed  Google Scholar 

  5. Yamada I, Nakagawa T, Matsushima Y et al (2001) High-resolution turbo magnetic resonance angiography for diagnosis of Moyamoya disease. Stroke 32:1825–1831

    Article  PubMed  CAS  Google Scholar 

  6. Hasuo K, Mihara F, Matsushima T (1998) MRI and MR angiography in moyamoya disease. J Magn Reson Imaging 8:762–726

    Article  PubMed  CAS  Google Scholar 

  7. Kuroda S, Houkin K, Kamiyama H et al (1995) Regional cerebral hemodynamics in childhood moyamoya disease. Childs Nerv Syst 11:584–590

    Article  PubMed  CAS  Google Scholar 

  8. Touho H, Karasawa J, Ohnishi H (1996) Preoperative and postoperative evaluation of cerebral perfusion and vasodilatory capacity with. 99mTc-HMPAO SPECT and acetazolamide in childhood Moyamoya disease. Stroke 27:282–289

    Article  PubMed  CAS  Google Scholar 

  9. Tsuchiya K, Inaoka S, Mizutani Y et al (1998) Echo-planar perfusion MR of moyamoya disease. Am J Neuroradiol 19:211–216

    PubMed  CAS  Google Scholar 

  10. Yamada I, Himeno Y, Nagaoka T et al (1999) Moyamoya disease: evaluation with diffusion-weighted and perfusion echo-planar MR imaging. Radiology 212:340–347

    PubMed  CAS  Google Scholar 

  11. Petrella JR, Provenzale JM (2000) MR perfusion imaging of the brain: techniques and applications. Am J Roentgenol 175:207–219

    CAS  Google Scholar 

  12. Calamante F, Ganesan V, Kirkham FJ et al (2001) MR perfusion imaging in Moyamoya Syndrome: potential implications for clinical evaluation of occlusive cerebrovascular disease. Stroke 32:2810–2816

    Article  PubMed  CAS  Google Scholar 

  13. Togao O, Mihara F, Yoshiura T et al (2006) Cerebral hemodynamics in Moyamoya disease: correlation between perfusion-weighted MR imaging and cerebral angiography. Am J Neuroradiol 27:391–397

    PubMed  CAS  Google Scholar 

  14. Kim SK, Wang KC, Oh CW et al (2003) Evaluation of cerebral hemodynamics with perfusion MRI in childhood moyamoya disease. Pediatr Neurosurg 38:68–75

    Article  PubMed  Google Scholar 

  15. Srinivasan A, Goyal M, Azri FA et al (2006) State of the art imaging of stroke. Radiographics 26:S75–S95

    Article  PubMed  Google Scholar 

  16. Wintermark M, Thiran JP, Maeder P et al (2001) Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT: a validation study. Am J Neuroradiol 22:905–914

    PubMed  CAS  Google Scholar 

  17. Koenig M, Klotz E, Luka B et al (1998) Perfusion CT of the brain: diagnostic approach for early detection of ischemic stroke. Radiology 209:85–93 20

    PubMed  CAS  Google Scholar 

  18. Rowley HA, Roberts TP (2004) Clinical perspectives in perfusion: neuroradiologic applications. Top Magn Reson Imaging 15:28–40

    Article  PubMed  Google Scholar 

  19. Luypaert R, Boujraf S, Sourbron S et al (2001) Diffusion and perfusion MRI: basic physics. Eur J Radiol 38:19–27

    Article  PubMed  CAS  Google Scholar 

  20. Speck O, Chang L, DeSilva NM et al (2000) Perfusion MRI of the human brain with dynamic susceptibility contrast: gradient-echo versus spin-echo techniques. J Magn Reson Imaging 12:381–387

    Article  PubMed  CAS  Google Scholar 

  21. Detre JA, Alsop DC (1999) Perfusion magnetic resonance imaging with continuous arterial spin labeling: methods and clinical applications in the central nervous system. Eur J Radiol 30:115–124

    Article  PubMed  CAS  Google Scholar 

  22. Lee M, Zaharchuk G, Guzman R et al (2009) Quantitative hemodynamic studies in moyamoya disease: a review. Neurosurg Focus 26:E5

    Article  PubMed  Google Scholar 

  23. Kim JH, Lee EJ, Lee SJ et al (2002) Comparative evaluation of cerebral blood volume and cerebral blood flow in acute ischemic stroke by using perfusion-weighted MR imaging and SPECT. Acta Radiol 43:365–370

    Article  PubMed  CAS  Google Scholar 

  24. Hatazawa J, Shimosegawa E, Toyoshima H et al (1999) Cerebral blood volume in acute brain infarction: a combined study with dynamic susceptibility contrast MRI and 99mTc-HMPAO-SPECT. Stroke 30:800–806

    Article  PubMed  CAS  Google Scholar 

  25. Lee SK, Kim DI, Jeong EK et al (2003) Postoperative evaluation of moyamoya disease with perfusion-weighted MR imaging: initial experience. Am J Neuroradiol 24:741–747

    PubMed  Google Scholar 

  26. Yun TJ, Cheon JE, Kim IO et al (2009) Childhood moyamoya disease: quantitative evaluation of perfusion MR imaging: correlation with clinical outcome after revascularization surgery. Radiology 251:216–223

    Article  PubMed  Google Scholar 

  27. Rim NJ, Kim HS, Shin YS et al (2008) CT perfusion parameter best reflects cerebrovascular reserve?: correlation of acetazolamide-challenged CT perfusion with single-photon emission CT in Moyamoya patients. Am J Neuroradiol 9:1658–1663

    Article  Google Scholar 

  28. Kang KH, Kim HS, Kim SY (2008) Quantitative cerebrovascular reserve measured by acetazolamide-challenged dynamic CT perfusion in ischemic adult Moyamoya disease: initial experience with angiographic correlation. Am J Neuroradiol 29:1487–1493

    Article  PubMed  CAS  Google Scholar 

  29. Sakamoto S, Ohba S, Shibukawa M et al (2006) CT perfusion imaging for childhood moyamoya disease before and after surgical revascularization. Acta Neurochir (Wien) 148:77–81

    Article  CAS  Google Scholar 

  30. Chen A, Shyr MH, Chen TY et al (2006) Dynamic CT perfusion imaging with acetazolamide challenge for evaluation of patients with unilateral cerebrovascular steno-occlusive disease. Am J Neuroradiol 27:1876–1881

    PubMed  CAS  Google Scholar 

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Correspondence to In-One Kim .

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Cheon, JE., Kim, IO. (2010). Perfusion Imaging in Moyamoya Disease. In: Cho, BK., Tominaga, T. (eds) Moyamoya Disease Update. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99703-0_28

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  • DOI: https://doi.org/10.1007/978-4-431-99703-0_28

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-99702-3

  • Online ISBN: 978-4-431-99703-0

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