Brain Perfusion SPECT in Moyamoya Disease

  • Jin Chul Paeng
  • Dong Soo Lee


For brain single photon emission computed tomography (SPECT), gamma cameras with multiple detectors (multihead cameras) are recommended. Although a single-head camera may be used for image acquisition, multihead cameras have two- or three-times higher sensitivity than those of single-head cameras, which can reduce scan time and enhance image quality. However, as only a few multihead gamma cameras that have more than three detectors are commercially available, dual-head cameras are at present used for brain SPECT in many institutes.


Single Photon Emission Compute Tomography Cerebral Blood Flow Single Photon Emission Compute Tomography Image Moyamoya Disease Oxygen Extraction Fraction 
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  1. 1.
    Nakagawara J, Nakamura J, Takeda R (1994) Assessment of postischemic reperfusion and diamox activation test in stroke using 99mTc-ECD SPECT. J Cereb Blood Flow Metab 14:S49–S57PubMedCrossRefGoogle Scholar
  2. 2.
    Dormehl IC, Oliver DW, Langen KJ et al (1997) Technetium-99 m-HMPAO, technetium-99 m-ECD and iodine-123-IMP cerebral blood flow measurements with pharmacological interventions in primates. J Nucl Med 38:1897–1901PubMedGoogle Scholar
  3. 3.
    Hyun Y, Lee JS, Rha JH et al (2003) Different uptake of 99mTc-ECD and 99mTc-HMPAO in the same brains: analysis by statistical parametric mapping. Eur J Nucl Med Mol Imaging 28:191–197CrossRefGoogle Scholar
  4. 4.
    Okazawa H, Yamauchi H, Sugimoto K et al (2001) Effects of acetazolamide on cerebral blood flow, blood volume, and oxygen metabolism: a positron emission tomography study with healthy volunteers. J Cereb Blood Flow Metab 21:1472–1479PubMedCrossRefGoogle Scholar
  5. 5.
    Bushberg JT, Stabin MG (2003) Radiopharmaceutical dosimetry. In: Sandler MP, Coleman RE, Patton JA et al (ed) Diagnostic nuclear medicine, 4th edn. Lippincott Willams & Wilkins, PhiladelphiaGoogle Scholar
  6. 6.
    Lee DS, Lee TH, Kim KM et al (1997) Optimization of subtraction brain perfusion SPECT with basal/acetazolamide consecutive acquisition. Korean J Nucl Med 31:330–338Google Scholar
  7. 7.
    Kim KM, Lee DS, Kim SK et al. (2000) Quantification of cerebrovascular reserve using Tc-99 m HMPAO brain SPECT and Lassen's algorithm. Korean J Nucl Med 34:322–335Google Scholar
  8. 8.
    Saito N, Nakagawara J, Nakamura H, et al (2004) Assessment of cerebral hemodynamics in childhood moyamoya disease using a quantitative and a semiquantitative IMP-SPECT study. Ann Nucl Med 18:323–331PubMedCrossRefGoogle Scholar
  9. 9.
    Lee HY, Paeng JC, Lee DS et al (2004) Efficacy assessment of cerebral arterial bypass surgery using statistical parametric mapping and probabilistic brain atlas on basal/acetazolamide brain perfusion SPECT. J Nucl Med 45:202–206PubMedGoogle Scholar
  10. 10.
    Lee JS, Lee DS, Kim YK et al (2004) Probabilistic map of blood flow distribution in the brain from the internal carotid artery. Neuroimage 23:1422–1431PubMedCrossRefGoogle Scholar
  11. 11.
    Kim SJ, Kim IJ, Kim YK et al (2008) Probabilistic anatomic mapping of cerebral blood flow distribution of the middle cerebral artery. J Nucl Med 49:39–43PubMedCrossRefGoogle Scholar
  12. 12.
    Lee JS, Lee DS (2005) Analysis of functional brain images using population-based probabilistic atlas. Curr Med Imaging Rev 1:81–87CrossRefGoogle Scholar
  13. 13.
    Ogawa A, Sakurai Y, Kayama T et al (1989) Regional cerebral blood flow with age: changes in rCBF in childhood. Neurol Res 11:173–176PubMedGoogle Scholar
  14. 14.
    Kuwabara Y, Ichiya Y, Sasaki M et al (1996) Cerebellar vascular response to acetazolamide in crossed cerebellar diaschisis: a comparison of 99mTc-HMPAO single-photon emission tomography with 15O-H2O positron emission tomography. Eur J Nucl Med 23:683–689PubMedCrossRefGoogle Scholar
  15. 15.
    Hong YH, Ahn TB, Oh CW et al (2002) Hemichorea as an initial manifestation of moyamoya disease: reversible striatal hypoperfusion demonstrated on single photon emission computed tomography. Mov Disord 17:1380–1383PubMedCrossRefGoogle Scholar
  16. 16.
    Chu MK, Lee IH, Kim DI (2001) Moyamoya disease initially presenting visual field defect. Yonsei Med J 42:566–570PubMedGoogle Scholar
  17. 17.
    Yamada I, Murata Y, Umehara I et al (1996) SPECT and MRI evaluations of the posterior circulation in moyamoya disease. J Nucl Med 37:1613–1617PubMedGoogle Scholar
  18. 18.
    Jeffree RL, Stoodley MA (2009) STA-MCA bypass for symptomatic carotid occlusion and haemodynamic impairment. J Clin Neurosci 16:226–235PubMedCrossRefGoogle Scholar
  19. 19.
    Lee DS, Hyun IY, Wang KC et al (1998) Evaluation of surgical outcome with pre- and post-operative rest/acetazolamide Tc-99 m HMPAO SPECT in children with moyamoya disease. Kor J Nucl Med 32:314–324Google Scholar
  20. 20.
    So Y, Lee HY, Kim SK et al (2005) Prediction of the clinical outcome of pediatric moyamoya disease with postoperative basal/acetazolamide stress brain perfusion SPECT after revascularization surgery. Stroke 36:1485–1489PubMedCrossRefGoogle Scholar
  21. 21.
    Hayashi T, Shirane R, Tominaga T (2009) Additional surgery for postoperative ischemic symptoms in patients with moyamoya disease: the effectiveness of occipital artery-posterior cerebral artery bypass with an indirect procedure: technical case report. Neurosurgery 64:E195–E196PubMedCrossRefGoogle Scholar
  22. 22.
    Kim SK, Wang KC, Kim IO et al (2002) Combined encephaloduroarteriosynangiosis and bifrontal encephalogaleo (periosteal) synangiosis in pediatric moyamoya disease. Neurosurgery 62:1456–1464.Google Scholar
  23. 23.
    Park JH, Yang SY, Chung YN et al (2007) Modified encephaloduroarteriosynangiosis with bifrontal encephalogaleoperiosteal synangiosis for the treatment of pediatric moyamoya disease. Technical note. J Neurosurg 106:237–242PubMedGoogle Scholar
  24. 24.
    Hosoda K, Kawaguchi T, Ishii K et al (2003) Prediction of hyperperfusion after carotid endarterectomy by brain SPECT analysis with semiquantitative statistical mapping method. Stroke 34:1187–1193PubMedCrossRefGoogle Scholar
  25. 25.
    Lee JW, Kim YK, Lee SM et al (2008) Assessment of hyperperfusion by brain perfusion SPECT in transient neurological deterioration after superficial temporal artery-middle cerebral artery anastomosis surgery. Nucl Med Mol Imaging 42:267–274Google Scholar
  26. 26.
    Kikuta K, Takagi Y, Fushimi Y et al (2008) “Target bypass”: a method for preoperative targeting of a recipient artery in superficial temporal artery-to-middle cerebral artery anastomoses. Neurosurgery 62:1434–1441PubMedGoogle Scholar
  27. 27.
    Sato S, Shirane R, Maruoka S et al (1999) Evaluation of neuronal loss in adult moyamoya disease by 123I-iomazenil SPECT. Surg Neurol 51:158–163PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2010

Authors and Affiliations

  1. 1.Department of Nuclear Medicine, Seoul National University HospitalSeoul National University College of MedicineSeoulRepublic of Korea
  2. 2.Department of Nuclear Medicine, and Department of Molecular Medicine and Biopharmaceutical SciencesSeoul National UniversitySeoulRepublic of Korea

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