Abstract
Connexin43 (Cx43) plays important roles of cell–cell communication as gap junctional molecules. Cx43-null mice showed abnormal branching morphogenesis in salivary gland. Gap junctional inhibitor 18α-GA inhibited branching morphogenesis in salivary glands organ culture. Further, exogenously addition of platelet-derived growth factor (PDGF) and fibroblast growth factor 10 (FGF10) took part from the partial rescue from the influence of the gap junctional inhibitor. These results indicate that gap junctional communication may regulate growth factor-induced branching morphogenesis in salivary glands.
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References
Yamamoto S, Fukumoto E, Yoshizaki K et al (2008) PDGF regulate salivary gland morphogenesis via FGF expression. JBC 283:23139–23149
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Suzuki, H., Yamada, A., Fukumoto, S. (2010). Gap junctional communication regulates salivary gland morphogenesis. In: Sasano, T., Suzuki, O. (eds) Interface Oral Health Science 2009. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99644-6_37
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DOI: https://doi.org/10.1007/978-4-431-99644-6_37
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-99643-9
Online ISBN: 978-4-431-99644-6
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