Abstract
CCN family members share common structural characteristics, and it has been suggested that they might have similar or redundant functions. Actually, different CCN proteins were reported to share some biological functions under certain biological conditions. In this study, we investigated all CCN members during osteoblast differentiation. As a result, this study demonstrated that CCN2 promotes osteoblast proliferation and differentiation at the all steps, whereas CCN3 strongly inhibited them. Other CCN members also play their roles during osteoblast differentiation.
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References
Bork P (1993) The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Lett 327:125–130
Perbal B, Takigawa M (2005) CCN proteins: a new family of cell growth and differentiation regulators. Imperial College Press, London
Schütze N, Schenk R, Fiedler J et al (2007) CYR61/CCN1 and WISP3/CCN6 are chemoattractive ligands for human multipotent mesenchymal stroma cells. BMC Cell Biol 8:45
Kawaki H, Kubota S, Suzuki A et al (2008) Functional requirement of CCN2 for intramembranous bone formation in embryonic mice. Biochem Biophys Res Commun 366:450– 456
Kumar S, Hand AT, Connor JR et al (1999) Identification and clonong of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions. J Biol Chem 274:17123–17131
Canalis E (2007) Nephroblastoma overexpressed (Nov) is a novel bone morphogenetic protein antagonist. Ann N Y Acad Sci 1116:50–58
French DM, Kaul RJ, D’Souza AL et al (2004) WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair. Am J Pathol 165:855–867
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Kawaki, H., Suzuki, M., Fujii, T., Takigawa, M., Takano-Yamamoto, T. (2010). Possible role of Ccn family members during osteoblast differentiation. In: Sasano, T., Suzuki, O. (eds) Interface Oral Health Science 2009. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99644-6_24
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DOI: https://doi.org/10.1007/978-4-431-99644-6_24
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-99643-9
Online ISBN: 978-4-431-99644-6
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