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Targeting Th2 Cells in Asthmatic Airways

  • Chapter
Allergy Frontiers: Future Perspectives

Part of the book series: Allergy Frontiers ((ALLERGY,volume 6))

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Abstract

Asthma represents a profound worldwide public health problem. The most effective anti-asthmatic drugs currently available include inhaled β2 -agonists and glucocorti-coids; these control asthma in about 90–95% of patients. However, the future therapies will need to focus on the 5–10% patients who do not respond well to these treatments and who account for ~50% of the health care costs of asthma [1, 2]. Strategies for the primary prevention of asthma remain in the realm of speculation and hypothesis [3]. Drug development for asthma has been directed at improving currently available drugs and finding new compounds that target the Th2-driven airway inflammatory response. Several new compounds have been developed to target specific components of the inflammatory process in asthma [e.g., anti-IgE antibodies (omalizumab), cytokines and/or chemokines antagonists, immunomodu-lators, antagonists of adhesion molecules], although they have not yet been proven to be particularly effective. In fact, only omalizumab has reached the market; it may be most cost-effective for patients with severe persistent asthma and frequent severe exacerbations requiring hospital care [3– 5]. In this chapter, we will review the role of current antiasthma drugs and future new chemical entities that can target Th2 cells in asthmatic airways. Some of these new Th2-oriented strategies may, in the future, not only control symptoms and modify the natural course of asthma, but also potentially prevent or cure the disease.

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Authors and Affiliations

  1. Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Università di Ferrara, Via Savonarola 9, Ferrara, 44100, Italy

    Gaetano Caramori, Paolo Casolari, Marco Contoli & Alberto Papi

  2. Airway Disease Section, National Heart and Lung Institute, Imperial College of London, London, UK

    Kazuhiro Ito & Ian M. Adcock

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  1. Gaetano Caramori
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  2. Kazuhiro Ito
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  3. Paolo Casolari
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  4. Marco Contoli
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  5. Alberto Papi
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  6. Ian M. Adcock
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Correspondence to Gaetano Caramori .

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  1. Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan

    Ruby Pawankar

  2. University of Southampton Southampton General Hospital, Tremona Road, Southampton, UK

    Stephen T. Holgate

  3. Children's Mercy Hospitals and Clinics UMKC School of Medicine, 2401 Gillham Road, Kansas City, MO, 64108, USA

    Lanny J. Rosenwasser

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Caramori, G., Ito, K., Casolari, P., Contoli, M., Papi, A., Adcock, I.M. (2010). Targeting Th2 Cells in Asthmatic Airways. In: Pawankar, R., Holgate, S.T., Rosenwasser, L.J. (eds) Allergy Frontiers: Future Perspectives. Allergy Frontiers, vol 6. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99365-0_8

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