Immunostimulatory (CpG) DNA-Based Therapies for the Treatment of Allergic Disease

  • Tomoko Hayashi
  • Eyal Raz
Part of the Allergy Frontiers book series (ALLERGY, volume 6)


Accumulating experimental data outline the potential use of CpG-ODN (i.e., TLR9 ligand) as an effective intervention for the prevention and treatment of allergic disorders. As discussed below, we propose that immunotherapy with CpG-ODN can be applied through two distinct strategies: (1) vaccination and (2) immunomodulation. CpG-ODN-based vaccination provides a long-term, allergen-specific, therapeutic efficacy as well as improved safety compared to conventional allergen vaccination (i.e., desensitization). In contrast, immunomodulation by CpG-ODN provides a short-term, allergen non-specific therapeutic efficacy that prevents allergic reactions in experimental models of allergic asthma, rhinitis, and conjunctivitis. The administration of CpG-ODN as immunomodulator intervenes in the sequential acquisition of allergic sensitization (e.g., Th2 phenotype spread) and organ pathology (e.g., airway remodeling). Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme of tryptophan catabolism, is induced by CpG-ODN and mediates, in part, these immunomodulatory and therapeutic effects. We propose that the insight gained from these two types of interventions in experimental models of allergy can help in the design of effective therapeutics for various human allergic diseases.


Atopic Dermatitis Allergic Rhinitis Allergic Asthma Clinical Immunology Allergen Challenge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2010

Authors and Affiliations

  • Tomoko Hayashi
    • 1
  • Eyal Raz
    • 1
  1. 1.Department of Medicine 0663University of California San DiegoLa JollaUSA

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