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Allergy Frontiers: Future Perspectives pp 305–319Cite as

Exosomes: Naturally Occurring Minimal Antigen-Presenting Units

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Part of the book series: Allergy Frontiers ((ALLERGY,volume 6))

Abstract

Exosomes are secreted spherical structures that are limited by a lipid bilayer and contain cytosolic components from the producing cell. Exosomes form in intracellular multivesicular compartments of the endocytic pathway, and are secreted upon fusion of these compartments with the plasma membrane. Secretion of exosomes had been described initially in reticulocytes differentiating into red blood cells, and proposed to allow elimination of useless proteins. But exosomes became the object of increasing interest from immunologists in the late 90s, when antigen presenting cells where shown to secrete exosomes bearing functional Major Histocompatibility Complex molecules, able to induce activation of cognate T cells. Since then, a large amount of work has strengthen the idea that exosomes secreted by antigen presenting cells could represent « minimal antigen presenting units ». In this review, we describe the biophysical and biochemical specificities of exosomes, give an overview of their antigen presenting functions, and discuss their use for immunotherapies.

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Authors and Affiliations

  1. Institut Curie, Centre de Recherche, 26 rue d'Ulm, Paris Cedex 05, 75245, France

    Elodie Segura & Clotilde Théry

  2. INSERM U932, 26 rue d'Ulm, Paris Cedex 05, 75245, France

    Elodie Segura & Clotilde Théry

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  1. Elodie Segura
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  2. Clotilde Théry
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Correspondence to Clotilde Théry .

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Editors and Affiliations

  1. Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan

    Ruby Pawankar

  2. University of Southampton Southampton General Hospital, Tremona Road, Southampton, UK

    Stephen T. Holgate

  3. Children's Mercy Hospitals and Clinics UMKC School of Medicine, 2401 Gillham Road, Kansas City, MO, 64108, USA

    Lanny J. Rosenwasser

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Segura, E., Théry, C. (2010). Exosomes: Naturally Occurring Minimal Antigen-Presenting Units. In: Pawankar, R., Holgate, S.T., Rosenwasser, L.J. (eds) Allergy Frontiers: Future Perspectives. Allergy Frontiers, vol 6. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99365-0_20

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