Dendritic Cell Vaccines

  • Martin Thurnher
Part of the Allergy Frontiers book series (ALLERGY, volume 6)


Dendritic cells are the sentinels of the immune system, which instruct the differentiation of helper T cells along various lineages and thus, critically determine the type, intensity, and duration of the immune response. The last decade witnessed the clinical implementation of the dendritic cell vaccination against cancer, which represents a paradigm of translational research and is a contribution to personalized medicine. Dendritic cell-based immunotherapy has been demonstrated to be feasible and well-tolerated and, moreover, to induce immune and clinical responses. The experience gained with dendritic cell therapy of cancer may form the basis for the extension of this therapy to the treatment of allergy and autoimmune disease including transplant rejection.


Dendritic Cell Renal Cell Carcinoma Atopic Dermatitis Metastatic Renal Cell Carcinoma Dendritic Cell Maturation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271.CrossRefPubMedGoogle Scholar
  2. 2.
    Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392:245.CrossRefPubMedGoogle Scholar
  3. 3.
    Reiner, S. L. 2007. Development in motion: helper T cells at work. Cell 129:33.CrossRefPubMedGoogle Scholar
  4. 4.
    Rutella, S., S. Danese, and G. Leone. 2006. Tolerogenic dendritic cells: cytokine modulation comes of age. Blood 108:1435.CrossRefPubMedGoogle Scholar
  5. 5.
    Rieser, C., G. Bock, H. Klocker, G. Bartsch, and M. Thurnher. 1997. Prostaglandin E2 and tumor necrosis factor alpha cooperate to activate human dendritic cells: synergistic activation of interleukin 12 production. J Exp Med 186:1603.CrossRefPubMedGoogle Scholar
  6. 6.
    Banchereau, J., and A. K. Palucka. 2005. Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol 5:296.CrossRefPubMedGoogle Scholar
  7. 7.
    Figdor, C. G., I. J. de Vries, W. J. Lesterhuis, and C. J. Melief. 2004. Dendritic cell immuno-therapy: mapping the way. Nat Med 10:475.CrossRefPubMedGoogle Scholar
  8. 8.
    Schuler, G., B. Schuler-Thurner, and R. M. Steinman. 2003. The use of dendritic cells in cancer immunotherapy. Curr Opin Immunol 15:138.CrossRefPubMedGoogle Scholar
  9. 9.
    Burnet, F. M. 1970. The concept of immunological surveillance. Prog Exp Tumor Res 13:1PubMedGoogle Scholar
  10. 10.
    Dunn, G. P., L. J. Old, and R. D. Schreiber. 2004. The immunobiology of cancer immunosur-veillance and immunoediting. Immunity 21:137.CrossRefPubMedGoogle Scholar
  11. 11.
    Thurnher, M., C. Radmayr, R. Ramoner, S. Ebner, G. Bock, H. Klocker, N. Romani, and G. Bartsch. 1996. Human renal-cell carcinoma tissue contains dendritic cells. Int J Cancer 68:1.CrossRefPubMedGoogle Scholar
  12. 12.
    Radmayr, C., G. Bock, A. Hobisch, H. Klocker, G. Bartsch, and M. Thurnher. 1995. Dendritic antigen-presenting cells from the peripheral blood of renal-cell-carcinoma patients. Int J Cancer 63:627.CrossRefPubMedGoogle Scholar
  13. 13.
    Thurnher, M., C. Radmayr, A. Hobisch, G. Bock, N. Romani, G. Bartsch, and H. Klocker. 1995. Tumor-infiltrating T lymphocytes from renal-cell carcinoma express B7-1 (CD80): T-cell expansion by T-T cell co-stimulation. Int J Cancer 62:559.CrossRefPubMedGoogle Scholar
  14. 14.
    Galon, J., A. Costes, F. Sanchez-Cabo, A. Kirilovsky, B. Mlecnik, C. Lagorce-Pages, M. Tosolini, M. Camus, A. Berger, P. Wind, F. Zinzindohoue, P. Bruneval, P. H. Cugnenc, Z. Trajanoski, W. H. Fridman, and F. Pages. 2006. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313:1960.CrossRefPubMedGoogle Scholar
  15. 15.
    Thompson, R. H., S. M. Kuntz, B. C. Leibovich, H. Dong, C. M. Lohse, W. S. Webster, S. Sengupta, I. Frank, A. S. Parker, H. Zincke, M. L. Blute, T. J. Sebo, J. C. Cheville, and E. D. Kwon. 2006. Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res 66:3381.CrossRefPubMedGoogle Scholar
  16. 16.
    Romani, N., S. Gruner, D. Brang, E. Kampgen, A. Lenz, B. Trockenbacher, G. Konwalinka, P. O. Fritsch, R. M. Steinman, and G. Schuler. 1994. Proliferating dendritic cell progenitors in human blood. J Exp Med 180:83.CrossRefPubMedGoogle Scholar
  17. 17.
    Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 179:1109.CrossRefPubMedGoogle Scholar
  18. 18.
    Caux, C., C. Dezutter-Dambuyant, D. Schmitt, and J. Banchereau. 1992. GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature 360:258.CrossRefPubMedGoogle Scholar
  19. 19.
    Banchereau, J., A. K. Palucka, M. Dhodapkar, S. Burkeholder, N. Taquet, A. Rolland, S. Taquet, S. Coquery, K. M. Wittkowski, N. Bhardwaj, L. Pineiro, R. Steinman, and J. Fay. 2001. Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine. Cancer Res 61:6451.PubMedGoogle Scholar
  20. 20.
    Brugarolas, J. 2007. Renal-cell carcinoma--molecular pathways and therapies. N Engl J Med 356:185.CrossRefPubMedGoogle Scholar
  21. 21.
    Holtl, L., C. Rieser, C. Papesh, R. Ramoner, G. Bartsch, and M. Thurnher. 1998. CD83+ blood dendritic cells as a vaccine for immunotherapy of metastatic renal-cell cancer. Lancet 352:1358.CrossRefPubMedGoogle Scholar
  22. 22.
    Holtl, L., C. Zelle-Rieser, H. Gander, C. Papesh, R. Ramoner, G. Bartsch, H. Rogatsch, A. L. Barsoum, J. H. Coggin, Jr., and M. Thurnher. 2002. Immunotherapy of metastatic renal cell carcinoma with tumor lysate-pulsed autologous dendritic cells. Clin Cancer Res 8:3369.PubMedGoogle Scholar
  23. 23.
    Holtl, L., R. Ramoner, C. Zelle-Rieser, H. Gander, T. Putz, C. Papesh, W. Nussbaumer, C. Falkensammer, G. Bartsch, and M. Thurnher. 2004. Allogeneic dendritic cell vaccination against metastatic renal cell carcinoma with or without cyclophosphamide. Cancer Immunol Immunother.Google Scholar
  24. 24.
    Jonuleit, H., U. Kuhn, G. Muller, K. Steinbrink, L. Paragnik, E. Schmitt, J. Knop, and A. H. Enk. 1997. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 27:3135.CrossRefPubMedGoogle Scholar
  25. 25.
    Rieser, C., R. Ramoner, L. Holtl, H. Rogatsch, C. Papesh, A. Stenzl, G. Bartsch, and M. Thurnher. 1999. Mature dendritic cells induce T-helper type-1-dominant immune responses in patients with metastatic renal cell carcinoma. Urol Int 63:151.CrossRefPubMedGoogle Scholar
  26. 26.
    Zelle-Rieser, C., A. L. Barsoum, F. Sallusto, R. Ramoner, J. W. Rohrer, L. Holtl, G. Bartsch, J. J. Coggin, and M. Thurnher. 2001. Expression and immunogenicity of oncofetal antigen-immature laminin receptor in human renal cell carcinoma. J Urol 165:1705.CrossRefPubMedGoogle Scholar
  27. 27.
    Cohen, H. T., and F. J. McGovern. 2005. Renal-cell carcinoma. N Engl J Med 353:2477.CrossRefPubMedGoogle Scholar
  28. 28.
    Kleinrath, T., C. Gassner, P. Lackner, M. Thurnher, and R. Ramoner. 2007. Interleukin-4 promoter polymorphisms: a genetic prognostic factor for survival in metastatic renal cell carcinoma. J Clin Oncol 25:845.CrossRefPubMedGoogle Scholar
  29. 29.
    Lanzavecchia, A., and F. Sallusto. 2005. Understanding the generation and function of memory T cell subsets. Curr Opin Immunol 17:326.CrossRefPubMedGoogle Scholar
  30. 30.
    Kay, A. B. 2001. Allergy and allergic diseases. First of two parts. N Engl J Med 344:30.CrossRefPubMedGoogle Scholar
  31. 31.
    Ziegler, S. F., and Y. J. Liu. 2006. Thymic stromal lymphopoietin in normal and pathogenic T cell development and function. Nat Immunol 7:709.CrossRefPubMedGoogle Scholar
  32. 32.
    Soumelis, V., P. A. Reche, H. Kanzler, W. Yuan, G. Edward, B. Homey, M. Gilliet, S. Ho, S. Antonenko, A. Lauerma, K. Smith, D. Gorman, S. Zurawski, J. Abrams, S. Menon, T. McClanahan, R. de Waal-Malefyt Rd, F. Bazan, R. A. Kastelein, and Y. J. Liu. 2002. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 3:673.PubMedCrossRefGoogle Scholar
  33. 33.
    Zhou, B., M. R. Comeau, T. De Smedt, H. D. Liggitt, M. E. Dahl, D. B. Lewis, D. Gyarmati, T. Aye, D. J. Campbell, and S. F. Ziegler. 2005. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol 6:1047.CrossRefPubMedGoogle Scholar
  34. 34.
    Ebner, S., V. A. Nguyen, M. Forstner, Y. H. Wang, D. Wolfram, Y. J. Liu, and N. Romani. 2007. Thymic stromal lymphopoietin converts human epidermal Langerhans cells into antigen-presenting cells that induce proallergic T cells. J Allergy Clin Immunol 119:982.CrossRefPubMedGoogle Scholar
  35. 35.
    Mazzoni, A., H. A. Young, J. H. Spitzer, A. Visintin, and D. M. Segal. 2001. Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization. J Clin Invest 108:1865.PubMedGoogle Scholar
  36. 36.
    Thurnher, M. 2007. Lipids in dendritic cell biology: messengers, effectors, and antigens. J Leukoc Biol 81:154.CrossRefPubMedGoogle Scholar
  37. 37.
    Liu, M. C., E. R. Bleecker, L. M. Lichtenstein, A. Kagey-Sobotka, Y. Niv, T. L. McLemore, S. Permutt, D. Proud, and W. C. Hubbard. 1990. Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma. Am Rev Respir Dis 142:126.PubMedGoogle Scholar
  38. 38.
    Gosset, P., F. Bureau, V. Angeli, M. Pichavant, C. Faveeuw, A. B. Tonnel, and F. Trottein. 2003. Prostaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cells. J Immunol 170:4943.PubMedGoogle Scholar
  39. 39.
    Hammad, H., M. Kool, T. Soullie, S. Narumiya, F. Trottein, H. C. Hoogsteden, and B. N. Lambrecht. 2007. Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. J Exp Med 204:357.CrossRefPubMedGoogle Scholar
  40. 40.
    Watanabe, N., Y. H. Wang, H. K. Lee, T. Ito, W. Cao, and Y. J. Liu. 2005. Hassall's corpuscles instruct dendritic cells to induce CD4 + CD25+ regulatory T cells in human thymus. Nature 436:1181.CrossRefPubMedGoogle Scholar
  41. 41.
    Steinman, R. M., and I. Mellman. 2004. Immunotherapy: bewitched, bothered, and bewildered no more. Science 305:197.CrossRefPubMedGoogle Scholar

Copyright information

© Springer 2010

Authors and Affiliations

  1. 1.Department of Urology, Immunotherapy UnitInnsbruck Medical University and KMT Center of Excellence in MedicineInnsbruckAustria

Personalised recommendations