Neuropeptide S Receptor 1: an Asthma Susceptibility Gene

  • Juha Kere
Part of the Allergy Frontiers book series (ALLERGY, volume 6)


The positional cloning of Neuropeptide S receptor (NPSR1) as an asthma susceptibility gene highlighted the notion that many relevant disease pathways may have remained undiscovered until recently. Robust replications of the genetic effect of NPSR1 in asthma have paved a way for interaction studies. In a rapid pace, knowledge has been accumulated of the ligand and its pharmacology as well as the target genes of NPSR1 signaling. Results from in vitro studies and mouse models point toward relevance for immune system cells or possibly neuronal effects in asthma.


Atopic Dermatitis Panic Disorder Allergy Clin Immunol Chimeric Receptor Asthma Susceptibility 
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Copyright information

© Springer 2010

Authors and Affiliations

  • Juha Kere
    • 1
    • 2
    • 3
  1. 1.Department of Biosciences and NutritionKarolinska InstitutetHuddingeSweden
  2. 2.Clinical Research CentreKarolinska University Hospital HuddingeHuddingeSweden
  3. 3.Department of Medical GeneticsBiomedicum, University of HelsinkiHelsinkiFinland

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