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Mast Cell-Specific Genes as New Drug Targets

  • Hirohisa Saito
Part of the Allergy Frontiers book series (ALLERGY, volume 6)

Abstract

Mast cells play a central role in immediate hypersensitivity, chronic inflammation, and tissue remodeling in asthma and allergies. Several attempts to clarify the pathogenesis of allergic diseases have been carried out using functional genomics such as microarray technology, providing us some novel biomarkers for diagnosis, therapeutic targets or understanding pathogenic mechanisms of these diseases. In this chapter, the outcomes of these analyses by the microarray approach are reviewed by focusing on the identification of genes specifically or preferentially expressed by human mast cells.

Keywords

Mast Cell Airway Smooth Muscle Allergy Clin Immunol Airway Remodel Human Mast Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2010

Authors and Affiliations

  1. 1.Department of Allergy and ImmunologyNational Research Institute for Child Health and DevelopmentSetagaya, TokyoJapan

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