Recalcitrant Asthma

  • Sharmilee M. Nyenhuis
  • William W. Busse
Part of the Allergy Frontiers book series (ALLERGY, volume 5)

Asthma is increasing in both prevalence and severity throughout the world [1]. Asthma affects approximately 8% of the adult population and up to 20% of the pediatric population in North America, Europe, and Australia [2]. The majority of these patients have mild to moderate persistent asthma that can be well controlled by environmental control measures and appropriate use of controller and reliever medications. It is estimated, however, that 5–10% of patients with asthma have severe disease that is recalcitrant to typical treatment modalities, including, in some cases, the administration of systemic corticosteroids. These patients have the greatest impairment in lifestyles, highest morbidity, and a disproportionate amount of health care cost associated with this disease [3–5]. Women and minorities share these burdens disproportionately as well. Our understanding of the pathophysiology of this subset of asthma patients is poorly understood. Consequently, these patients need a careful evaluation to uncover risk factors and novel approaches to control the disease.


Obstructive Sleep Apnea Severe Asthma Allergy Clin Immunol Respir Crit Peak Expiratory Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Sharmilee M. Nyenhuis
    • 1
  • William W. Busse
    • 1
    • 2
  1. 1.Division of Allergy and Immunology, Department of MedicineUniversity of WisconsinMadisonUSA
  2. 2.University of Wisconsin School of Medicine and Public HealthMadisonUSA

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