Mechanisms of Action of β2 Adrenoceptor Agonists

  • Ian P. Hall
  • Ian Sayers
Part of the Allergy Frontiers book series (ALLERGY, volume 5)

β2 adrenoceptor agonists have been the main stay bronchodilator agents used for the management of asthma for the last 50 years. These drugs have proven to be the most effective bronchodilators available. The first agent used widely in the management of asthma was isoprenaline (isoproterenol), a nonselective β adrenoceptor agonist. This was replaced by short acting β2 adrenoceptor selective agents, often called SABAs; the main agents used are salbutamol (albuterol) and terbutaline. More recently, long acting β2 agonists (LABAs), which have a prolonged duration of bronchodilator effect, have been developed, the major examples being formot-erol and salmeterol. A number of new LABAs are currently in development or phase II/III clinical trials, including agents such as indacaterol. This chapter deals with the molecular pharmacology underlying the control of β2 adrenoceptor signalling.


Airway Smooth Muscle Allergy Clin Immunol Adrenoceptor Agonist Human Airway Smooth Muscle Cell ADRB2 Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Ian P. Hall
    • 1
  • Ian Sayers
    • 1
  1. 1.Division of Therapeutics and Molecular MedicineUniversity Hospital of NottinghamNottinghamUK

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