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Antileukotrienes in Asthma and Rhinitis

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Allergy Frontiers: Therapy and Prevention

Part of the book series: Allergy Frontiers ((ALLERGY,volume 5))

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Leukotrienes are lipid mediators synthesized from arachidonic acid liberated from the membranes of activated inflammatory cells [1]. The subfamily of cysteinyl-leukotrienes (cys-LTs) represented by LTC4, LTD4 and LTE4 are the first inflammatory mediators to have a proven role in the pathophysiology of asthma [2] and which mimic many of the features of allergic rhinitis [3]. Antileukotriene drugs that block the synthesis of leukotrienes or antagonize cys-LT receptors have been licensed for asthma therapy in most countries in the last dozen years [4], with some of these drugs also being registered for use in allergic rhinitis [2]. This chapter will outline the sources and actions of cys-LTs in allergic airway inflammation and the clinical evidence underlying the use of antileukotriene drugs in asthma and allergic rhinitis.

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  1. Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY, USA

    Anthony Peter Sampson

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  2. University of Southampton Southampton General Hospital, Tremona Road, Southampton, UK

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  3. Children's Mercy Hospitals and Clinics UMKC School of Medicine, 2401 Gillham Road, Kansas City, MO, 64108, USA

    Lanny J. Rosenwasser

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Sampson, A.P. (2009). Antileukotrienes in Asthma and Rhinitis. In: Pawankar, R., Holgate, S.T., Rosenwasser, L.J. (eds) Allergy Frontiers: Therapy and Prevention. Allergy Frontiers, vol 5. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99362-9_5

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