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Antibody Deficiency Syndromes (Including Diagnosis and Treatment)

  • Kenneth Paris
  • Lily Leiva
  • Ricardo U. Sorensen
Part of the Allergy Frontiers book series (ALLERGY, volume 5)

Antibody deficiency syndromes range from an absence of all immunoglobulins (agammaglobulinemia) to milder, but clinically relevant, deficiencies of specific antibodies in patients with normal immunoglobulin concentrations. In clinical practice, physicians encounter many forms of antibody deficiencies that do not fit the strict criteria for each syndrome that has been defined by several expert groups in primary immunodeficiencies [1, 2]. We recognize that antibody deficiencies are the most frequently reported immunodeficiencies in different areas of the world [3] and antibody deficiencies are the most frequently encountered immunodeficiencies in clinical immunology practice. The antibody deficiencies with the least clinical impact are found at the highest frequency in the population. For example, IgA deficiency, which can be observed in asymptomatic individuals, is the most frequently encountered immunodeficiency [4] while agammaglobulinemias are relatively rare. There may be a common misconception that the less frequent severe antibody deficiency syndromes are not relevant in clinical practice. However, early diagnosis of an antibody deficiency requires awareness and a thorough evaluation and may prevent permanent sequelae from the severe infections that can occur.

Keywords

Allergy Clin Immunol Common Variable Immunodeficiency Primary Immunodeficiency Disease Antibody Deficiency Polysaccharide Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Kenneth Paris
    • 1
    • 2
  • Lily Leiva
    • 3
    • 4
  • Ricardo U. Sorensen
    • 5
    • 6
  1. 1.Department of PediatricsResearch Institute for Children 4th Floor, Louisiana State University Health Sciences CenterUSA
  2. 2.Jeffrey Modell Diagnostic CenterChildren's HospitalNew OrleansUSA
  3. 3.Department of PediatricsResearch Institute for Children 4th Floor, Louisiana State University Health Sciences CenterUSA
  4. 4.Jeffrey Modell Diagnostic CenterChildren's HospitalNew OrleansUSA
  5. 5.Department of PediatricsResearch Institute for Children 4th Floor, Louisiana State University Health Sciences CenterUSA
  6. 6.Jeffrey Modell Diagnostic CenterChildren's HospitalNew OrleansUSA

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