Use of Theophylline and Sodium Cromoglycate in Pediatric Asthma

  • Akihiro Morikawa
Part of the Allergy Frontiers book series (ALLERGY, volume 5)

Theophylline and sodium cromoglycate are old drugs used in the treatment of asthma, but in some patients, they are still useful for maintenance therapy. Theophylline is not only a bronchodilator, but also has anti-inflammatory effects [1] due to multiple mechanisms including adenosine receptor antagonism and epigenetic influences over inflammatory gene expression both of which occur at lower concentrations (5–10 μm ml −1). In Japan, slow release theophylline is still used as a controller therapy except in infants with asthma [2]. Sodium cromoglycate produces only minimal side effects and is also used as a controller in persistent asthma, especially in infantile asthma.


Allergy Clin Immunol Sodium Cromoglycate HDAC Activity Nedocromil Sodium Pediatric Asthma 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Kitakanto Allergy Institute, Kibounoie HospitalMidoriJapan

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