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Immunomodulatory Role of Bacillus Calmette-Guérin in the Prevention and Therapy of Allergy and Asthma

  • Toluwalope O. Makinde
  • Againdra K. Bewtra
  • Devendra K. Agrawal
Part of the Allergy Frontiers book series (ALLERGY, volume 5)

There has been an increased prevalence and severity of asthma in recent decades. This increase in episodes of allergic asthma has been more evident in westernized nations where most infectious diseases have been markedly reduced by early immunization programs and extensive use of antibiotics [1]. Better diagnosis and exposure to conventional allergens have not been able to sufficiently explain the increased incidence of asthma. A substantial shift in genome does not occur in the span of only a few decades, and so genetic predisposition has also been ruled out as a major factor contributing to the observed increase in atopic diseases [1]. Paradoxically, several investigators have observed an inverse relationship between atopic diseases, such as asthma, and exposure to infectious pathogens including Mycobacterium bacilli [2].

Many immune cells and mediators contribute to the development and exacerbation of allergic response and asthma. It is, therefore, not surprising to see the development of numerous drugs to combat the disease. None of these therapies has a curative effect and there still remains a cohort of patients who are unresponsive to these treatments [3]. This warrants continued research in this area to develop more effective therapeutic approaches with minimal side effects to control this debilitating disease. In the following sections, we critically reviewed the role of BCG in preventing a T helper (TH) 2 response, its effect on immune cells, and its efficacy as a potential therapeutic agent to control allergy and asthma.

Keywords

Tuberculin Skin Test Allergic Asthma Atopic Disease Mycobacterium Bovis Mycobacterial Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Toluwalope O. Makinde
    • 1
  • Againdra K. Bewtra
    • 2
  • Devendra K. Agrawal
    • 3
  1. 1.Department of Biomedical SciencesCreighton University School of MedicineOmahaUSA
  2. 2.Department of Internal MedicineCreighton University School of MedicineOmahaUSA
  3. 3.Departments of Biomedical SciencesInternal Medicine, and Medical Microbiology and Immunology, Creighton University School of MedicineOmahaUSA

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