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Allergy Frontiers: Therapy and Prevention pp 465–482Cite as

Emerging Nonsteroidal Anti-Inflammatory Therapies Targeting Specific Mechanisms in Asthma and Allergy

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Part of the book series: Allergy Frontiers ((ALLERGY,volume 5))

Our current understanding of asthma pathophysiology has changed considerably during the last 20 years. From being regarded as an inflammatory disorder mainly affecting the central airways, asthma is now recognized as a heterogeneous, systemic disorder, involving the respiratory tract from nose to peripheral airways. Chronic inflammation in asthma is associated with the development of structural changes within the airways (the so-called “remodelling”) and airway hyperresponsiveness. While most asthma phenotypes are easily controlled with fairly low doses of corti-costeroids, others appear more or less steroid-resistant. Inflammation involving mast cells and neutrophils is an example of such underlying mechanisms. Another example of corticosteroid resistance is over production of cysteinyl leukotrienes or tumour necrosis factor (TNF) - α in other asthma phenotypes [1, 2]. All together, this motivates the search for more systemic therapies, complementary to corticos-teroid treatment. In this chapter, we will highlight some present and future non-steroidal therapies, all given by systemic route.

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Authors and Affiliations

  1. Department of Respiratory Medicine and Allergology, Heart and Lund Division, University Hospital of Lund, 221 85, Sweden

    Leif Bjermer

  2. Departments of Allergology and Pulmonology, Erasmus University Medical Center, Rotterdam, The Netherlands

    Zuzana Diamant

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  1. Leif Bjermer
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  2. Zuzana Diamant
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Editors and Affiliations

  1. Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan

    Ruby Pawankar

  2. University of Southampton Southampton General Hospital, Tremona Road, Southampton, UK

    Stephen T. Holgate

  3. Children's Mercy Hospitals and Clinics UMKC School of Medicine, 2401 Gillham Road, Kansas City, MO, 64108, USA

    Lanny J. Rosenwasser

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Bjermer, L., Diamant, Z. (2009). Emerging Nonsteroidal Anti-Inflammatory Therapies Targeting Specific Mechanisms in Asthma and Allergy. In: Pawankar, R., Holgate, S.T., Rosenwasser, L.J. (eds) Allergy Frontiers: Therapy and Prevention. Allergy Frontiers, vol 5. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99362-9_28

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  • DOI: https://doi.org/10.1007/978-4-431-99362-9_28

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