Anti-IgE in Allergic Airway Diseases: Indications and Applications

  • Jennifer Preston DeMore
  • William W. Busse
Part of the Allergy Frontiers book series (ALLERGY, volume 5)

IgE plays a role in both the initial sensitization to antigen and the subsequent effects upon repeat exposure. For sensitization, inhaled antigen is ingested by antigen presenting dendritic cells that line the airway, and then processed and presented to antigen-specific T cells. The subsequent production of cytokines stimulates B cells to produce antigen-specific IgE, which then binds to the surface of mast cells and basophils via the high-affinity receptor for IgE, namely Fc εRI [1] (Fig. 1a).

Upon repeat exposure to an inhaled antigen, there is cross-linking of IgE bound to the surface of mast cells and basophils. This interaction signals mast cells and basophils to degranulate, releasing mediators such as histamine, prostaglandin, and leukotrienes, and to stimulate chemokine and cytokine production. These mediators cause an early or acute phase reaction and, under some circumstances, can lead to a late-phase reaction.


Allergic Rhinitis Allergy Clin Immunol Allergic Asthma Seasonal Allergic Rhinitis Allergic Airway Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Jennifer Preston DeMore
    • 1
  • William W. Busse
    • 1
    • 2
  1. 1.University of Wisconsin School of Medicine and Public HealthMadisonUSA
  2. 2.Division of Allergy and Immunology, Department of MedicineUniversity of WisconsinUSA

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