The Efficacy of a Bionic Baroreflex System in an Abdominal Aortic Aneurysm Surgery
Purpose: We had proposed a novel therapeutic strategy against central baroreflex failure: implementation of an artificial baroreflex system to automatically regulate sympathetic vasomotor tone, i. e., a bionic baroreflex system (BBS), and tested its efficacy in a model of sudden hypotension during orthopaedic surgery. In present study we utilized a BBS during an abdominal aortic aneurysm surgery to treat hypotension occurred when declamping an aorta.
Method: Ten patients (73–84 years old, 7 males) who underwent abdominal aortic aneurysm repair were enrolled. The BBS consisted of a computer-controlled negative feedback circuit that sensed arterial pressure (AP) and automatically computed the frequency (STM) of a pulse train required to stimulate sympathetic nerves via an epidural catheter placed at the level of the lower thoracic spinal cord.