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Intermittent Pressure Augmented Retrograde Cerebral Perfusion

  • Shinichi Takamoto
  • Kan Nawata
  • Tetsuro Morota
  • Kazuo Kitahori
  • Mitsuhiro Kawata
Conference paper

Having an experimental finding that intermittent pressure augmented RCP (IPA-RCP) significantly reduced postoperative brain damage in a canine model, we utilize IPA-RCP in clinical settings. IPA-RCP requires intermittent augmentation of superior vena caval pressure up to 45 mmHg every thirty seconds, while conventional RCP (C-RCP) continuous pressure of 15 mmHg. We examined the impact of IPA-RCP on the outcome of aortic arch surgery. Methods Since January 1999, we have had seventy-seven operations of total arch replacement via midsternal incision, excluding cases of emergency, active infection or with any history of cer-ebrovascular events. We retrospectively compared 45 patients undergoing C-RCP from January 1999 to April 2002 with 36 patients undergoing IPA-RCP from May 2002 to December 2006. Univariable and multivariable analysis were performed to examine statistically about the incidence of neurological morbidity, that is, delayed awakening, stroke and postoperative delirium.

Keywords

Aortic Arch Multivariable Analysis Body Weight Gain Valve Surgery Active Infection 
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Copyright information

© Springer 2009

Authors and Affiliations

  • Shinichi Takamoto
    • 1
  • Kan Nawata
    • 1
  • Tetsuro Morota
    • 1
  • Kazuo Kitahori
    • 1
  • Mitsuhiro Kawata
    • 1
  1. 1.The Department of Cardiothoracic SurgeryThe University of Tokyo HospitalTokyoJapan

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