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Expression and localization of pituitary adenylate cyclase-activating polypeptide (PACAP) specific receptor (PAC1R) after traumatic brain injury in mice

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Transmitters and Modulators in Health and Disease

Summary

PACAP is a pleiotropic peptide and is well known to suppress neuronal cell death after ischemic injury through PACAP specific receptor (PAC1R). However, the pathological role of PAC1R is not elicited well on traumatic injured brain. Therefore, the purpose of this study is to investigate the expression and localization of PAC1R after traumatic brain injury (TBI) with immunohistochemistry. The PAC1R-immunoreactions (ir) were detected in peri-contusional area 3h after TBI and gradually increased up to 7d. Double immunohistochemical studies were revealed that the PAC1R-ir were co-localized with a microglial marker, CD11b. At 7d after TBI, the PAC1R-ir were merged with CD11b and with GFAP, an astroglial marker. These results suggested that PAC1R expresses in microglia and astrocyte with different time points after TBI, and PACAP and its receptor might play an important role for brain injury as well as ischemia.

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References

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Authors and Affiliations

  1. Department of Emergency and Critical Care Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Kentaro Morikawa, Kenji Dohi, Yuko Mihara & Tohru Aruga

  2. Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Sachiko Yofu, Tomoya Nakamachi, Hirokazu Ohtaki & Seiji Shioda

Authors
  1. Kentaro Morikawa
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  2. Kenji Dohi
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  3. Sachiko Yofu
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  4. Yuko Mihara
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  5. Tomoya Nakamachi
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  6. Hirokazu Ohtaki
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  7. Seiji Shioda
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  8. Tohru Aruga
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Editor information

Editors and Affiliations

  1. Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Seiji Shioda M.D., Ph.D. (Professor) (Professor)

  2. Department of Physiology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Ikuo Homma M.D., Ph.D. (Professor) (Professor)

  3. Department of Psychiatry, Karasuyama Hospital, Showa University School of Medicine, 6-11-11, Kitakarasuyama, Setagaya-ku, Tokyo, 157-8577, Japan

    Nobumasa Kato M.D., Ph.D. (Professor) (Professor)

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© 2009 Springer

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Morikawa, K. et al. (2009). Expression and localization of pituitary adenylate cyclase-activating polypeptide (PACAP) specific receptor (PAC1R) after traumatic brain injury in mice. In: Shioda, S., Homma, I., Kato, N. (eds) Transmitters and Modulators in Health and Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99039-0_19

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  • DOI: https://doi.org/10.1007/978-4-431-99039-0_19

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-99038-3

  • Online ISBN: 978-4-431-99039-0

  • eBook Packages: MedicineMedicine (R0)

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