Summary
Orexin is a regulatory peptide involved in the control of feeding, motivation and adaptive behaviors. To examine the role of orexin in mastication, whole cell patch-clamp recordings from mesencephalic trigeminal sensory neurons (Mes V neurons), which are critical components of the circuits controlling oral-motor activity, were performed on brainstem slice preparations from Wistar rats aged between postnatal days (P) 0-17. By bath-application of orexin-A (200–500 nM), small membrane depolarizations with decreases of the input resistance were observed at the resting potential in the presence of tetrodotoxin. In rats older than P7 or P8, it is known that the burst discharges are induced by a depolarizing step pulse at a holding potential of about -40 to -50 mV in Mes V neurons. Such conditional burst discharges in Mes V neurons were reduced to 61% of control by bath-application of orexin-A. Persistent sodium currents, which contribute to production of such conditional burst discharges, were also reduced by orexin-A. These results suggest that orexin modulates oral-motor behavior via Mes V neurons.
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Nakayama, K., Mochizuki, A., Nakamura, S., Inoue, T. (2009). Orexin modulates neuronal activities of mesencephalic trigeminal sensory neurons in rats. In: Shioda, S., Homma, I., Kato, N. (eds) Transmitters and Modulators in Health and Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-99039-0_15
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DOI: https://doi.org/10.1007/978-4-431-99039-0_15
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