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Allergy Frontiers: Diagnosis and Health Economics pp 63–79Cite as

Nasal and Bronchial Nonallergic Provocation Tests

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Part of the book series: Allergy Frontiers ((ALLERGY,volume 4))

Provocation challenges, both bronchial and nasal, can be performed with nonselective or selective stimuli. These are often referred to as nonallergic and allergic stimuli respectively. This chapter deals with nonselective (nonallergic) bronchial and nasal provocation tests.

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References

  1. Hargreave FE, Ryan G, Thomson NC, O'Byrne PM, Latimer K, Juniper EF, Dolovich J (1981) Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance. J Allergy Clin Immunol 68:347–355

    Article  PubMed  CAS  Google Scholar 

  2. Pauwels R, Joos G, Van Der Straeten M (1988) Bronchial hyperresponsiveness is not bronchial hyperresponsiveness is not bronchial asthma. Clin Allergy 18:317–321

    Article  PubMed  CAS  Google Scholar 

  3. Hargreave FE, Leigh R, Parameswaran K (2006) Asthma as a disease concept. Lancet 368:1415–1416.

    Article  PubMed  CAS  Google Scholar 

  4. Juniper EF, Frith PA, Dunnett C, Cockcroft DW, Hargreave FE (1978) Reproducibility and comparison of responses to inhaled histamine and methacholine. Thorax 33:705–710

    Article  PubMed  CAS  Google Scholar 

  5. Alexander HL, Paddock R (1921) Bronchial asthma: response to pilocarpin and epinephrin. Arch Intern Med 27:184–191

    CAS  Google Scholar 

  6. Curry JJ, Lowell FC (1948) Measurement of vital capacity in asthmatic subjects receiving histamine and acetyl-beta-methylcholine — a clinical study. J Allergy 19:9–18

    Article  PubMed  CAS  Google Scholar 

  7. Tiffeneau R, Pinelli A (1947) Air circulant et air captif dans l'exploration de la fonction ven-tilatrice pulmonaire. Paris Méd 37:624–628

    PubMed  CAS  Google Scholar 

  8. Tiffeneau R, Beauvallet M (1945) Epreuve de bronchoconstriction et de bronchodilation par aerosols. Bull Acad de Med 129:165–168

    Google Scholar 

  9. Cockcroft DW, Berscheid BA, Murdock KY (1983) Unimodal distribution of bronchial responsiveness to inhaled histamine in a random human population. Chest 83:751–754

    Article  PubMed  CAS  Google Scholar 

  10. Cockcroft DW (1985) Measurement of airway responsiveness to inhaled histamine or methacholine: method of continuous aerosol generation and tidal breathing inhalation. In: Hargreave FE, Woolcock AJ (eds) Airway Responsiveness: Measurement and Interpretation. Astra Pharmaceuticals Canada Ltd, pp 22–28

    Google Scholar 

  11. Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG, MacIntyre NR, McKay RT, Wanger JS, Anderson SD, Cockcroft DW, Fish JE, Sterk PJ (2000) Guidelines for methacholine and exercise challenge testing-1999. Am J Respir Crit Care Med 161:309–329

    PubMed  CAS  Google Scholar 

  12. Cockcroft DW, Killian DN, Mellon JJA, Hargreave FE (1977) Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy 7:235–243

    Article  PubMed  CAS  Google Scholar 

  13. deVries K, Goei JT, Booy-Noord H,Orie NGM (1962) Changes during 24 hours in the lung function and histamine hyperreactivity of the bronchial tree in asthmatic and bronchitic patients. Int Arch Allergy 20:93–101

    PubMed  Google Scholar 

  14. Cockcroft DW, Hurst TS, Gore BP (1989) Importance of evaporative water losses during standardized nebulized inhalation provocation tests. Chest 96:505–508

    Article  PubMed  CAS  Google Scholar 

  15. Ryan G, Dolovich MB, Roberts RS, Frith PA, Juniper EF, Hargreave FE, Newhouse MT (1981) Standardization of inhalation provocation tests: two techniques of aerosol generation and inhalation compared. Am Rev Respir Dis 123:195–199

    PubMed  CAS  Google Scholar 

  16. Chai H, Farr RS, Froehlich LA, Mathison DA, McLean JA, Rosenthal RR, Sheffer AL II, Spector SL, Townley RG (1975) Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol 56:323–327

    Article  PubMed  CAS  Google Scholar 

  17. Davis BE, Cockcroft DW (2000) Calculation of provocation concentration causing a 20% fall in FEV1: comparison of lowest vs. highest post-challenge FEV1. Chest 117:881–883

    Article  PubMed  CAS  Google Scholar 

  18. Cockcroft DW, Murdock KY, Mink JT (1983) Determination of histamine PC20: comparison of linear and logarithmic interpolation. Chest 84:505–506

    Article  PubMed  CAS  Google Scholar 

  19. Todd DC, Davis BE, Hurst TS, Cockcroft DW (2004) Dosimeter methacholine challenge: comparison of maximal versus submaximal inhalations. J Allergy Clin Immunol 114:517–519

    Article  PubMed  CAS  Google Scholar 

  20. Cockcroft DW, Davis BE, Todd DC, Smycniuk AJ (2005) Methacholine challenge: comparison of two methods. Chest 127:839–844

    Article  PubMed  CAS  Google Scholar 

  21. Allen ND, Davis BE, Hurst TS, Cockcroft DW (2005) Difference between dosimeter and tidal breathing methacholine challenge: contributions of dose and deep inspiration bronchoprotection. Chest 128:4018–4023

    Article  PubMed  Google Scholar 

  22. Cockcroft DW, Davis BE (2006) The bronchoprotective effect of inhaling methacholine by using total lung capacity inspirations has a marked influence on the interpretation of the test result. J Allergy Clin Immunol 117:1244–1248

    Article  PubMed  CAS  Google Scholar 

  23. Hopp RJ, Bewtra AK, Nair NM, Townley RJ (1984) Specificity and sensitivity of metha-choline inhalation challenge in normal and asthmatic children. J Allergy Clin Immunol 74:154–158

    Article  PubMed  CAS  Google Scholar 

  24. Cockcroft DW, Berscheid BA, Murdock KY, Gore BP (1992) Sensitivity and specificity of histamine PC20 measurements in a random selection of young college students. J Allergy Clin Immunol 89:23–30

    Article  PubMed  CAS  Google Scholar 

  25. Holzer K, Anderson SD, Douglass J (2002) Exercise in elite summer athletes: challenges for diagnosis. J Allergy Clin Immunol 110:374–380

    Article  PubMed  Google Scholar 

  26. Heimdal JH, Roksund OD, Halvorsen T, Skadberg BT, Olofsson J (2006) Continuous laryngoscopy exercise test: a method for visualizing laryngeal dysfunction during exercise. Laryngoscope 116:52–57.

    Article  PubMed  Google Scholar 

  27. Cockcroft DW, Mink JT (1979) Isocyanate-induced asthma in an automobile spray painter. Can Med Assoc J 121:602–604

    PubMed  CAS  Google Scholar 

  28. Pattemore PK, Asher MI, Harrison AC, Mitchell EA, Rea HH, Stewart AW (1990) The interrelationship among bronchial hyperresponsiveness, the diagnosis of asthma, and asthma symptoms. Am Rev Respir Dis 142:549–554

    PubMed  CAS  Google Scholar 

  29. Woolcock AJ, Yan K, Salome CM (1988) Effect of therapy on bronchial hyperresponsiveness in the long-term management of asthma. Clin Allergy 18:165–176

    Article  PubMed  CAS  Google Scholar 

  30. Ramsdell JW, Nachtwey FG, Moser KM (1982) Bronchial hyperreactivity in chronic obstructive bronchitis. Am Rev Respir Dis 126:829–832

    PubMed  CAS  Google Scholar 

  31. Verma VK, Cockcroft DW, Dosman JA (1988) Airway hyperresponsiveness to inhaled histamine in chronic obstructive airways disease: chronic bronchitis vs. emphysema. Chest 94:456–461

    Google Scholar 

  32. Irwin RS, French CT, Smyrnios NA, Curley FJ (1997) Interpretation of positive results of a methacholine inhalation challenge and 1 week of inhaled bronchodilator use in diagnosing and treating cough-variant asthma. Arch Intern Med 22:1981–1987

    Article  Google Scholar 

  33. Gibson PG, Dolovich J, Denburg J, Ramsdale EH, Hargreave FE (1989) Chronic cough: eosinophilic bronchitis without asthma. Lancet 1:1346–1348

    Article  PubMed  CAS  Google Scholar 

  34. Joos GF, O'Connor B, Anderson SD, Chung F, Cockcroft DW, Dahlen B, DiMaria G, Foresi A, Hargreave FE, Holgate ST, Inman M, Lotvall J, Magnussen H, Polosa R, Postma DS, Riedler J (2003) Indirect airway challenges. Eur Respir J 21:1050–1068

    Article  PubMed  CAS  Google Scholar 

  35. Van Schoor J, Pauwels R, Joos G (2005) Indirect bronchial hyperresponsiveness: the coming of age of a specific group of bronchial challenges. Clin Exp Allergy 35:250–261

    Article  PubMed  Google Scholar 

  36. Godfrey S, Springer C, Noviski N, Maayan C, Avital A (1991) Exercise but not methacholine differentiates asthma from chronic lung disease in children. Thorax 46:488–492

    Article  PubMed  CAS  Google Scholar 

  37. Ramsdale EH, Morris MM, Roberts RS, Hargreave FE (1984) Bronchial responsiveness to methacholine in chronic bronchitis: relationship to airflow obstruction and cold air responsiveness. Thorax 39:912–918

    Article  PubMed  CAS  Google Scholar 

  38. Polosa R, Ciamarra I, Mangano G, Prosperini G, Pistorio MP, Vancheri C, Crimi N (2000) Bronchial hyperresponsiveness and airway inflammation markers in nonasthmatics with allergic rhinitis. Eur Respir J 15:30–35

    Article  PubMed  CAS  Google Scholar 

  39. van den Berge M, Meijer RJ, Kerstjens HA, de Reus DM, Koeter GH, Kauffman HF, Postma DS (2001) PC20 adenosine 5′-monophosphate is more closely associated with airway inflammation in asthma than PC20 methacholine. Am J Respir Crit Care Med 163:1546–1550

    Google Scholar 

  40. van Velzen E, van den Bos JW, Benckhuijsen JA, van Essel T, de Bruijn R, Aalbers R (1996) Effect of allergen avoidance at high altitude on direct and indirect bronchial hyperresponsive-ness and markers of inflammation in children with allergic asthma. Thorax 51:582–584

    Article  PubMed  Google Scholar 

  41. van den Berge M, Kerstjens HA, Meijer RJ, de Reus DM, Koeter GH, Kauffman HF, Postma DS (2001) Corticosteroid-induced improvement in the PC20 of adenosine monophos-phate is more closely associated with reduction in airway inflammation than improvement in the PC20 of methacholine. Am J Respir Crit Care Med 164:1127–1132

    PubMed  Google Scholar 

  42. Woolcock AJ, Cheung W, Salome C (1986) Relationship between bronchial responsiveness to propranolol and histamine. Am Rev Respir Dis 133:A177

    Google Scholar 

  43. Anderson SD, Argyros GJ, Magnussen H, Holzer K (2001) Provocation by eucapnic voluntary hyperpnoea to identify exercise induced bronchoconstriction. Br J Sports Med 35:344–347

    Article  PubMed  CAS  Google Scholar 

  44. O'Byrne PM, Ryan G, Morris M, McCormack D, Jones NL, Morse JLC, Hargreave FE (1982) Asthma induced by cold air and its relation to nonspecific bronchial responsiveness to metha-choline. Am Rev Respir Dis 125:281–285

    Google Scholar 

  45. Schoeffel RE, Anderson SD, Altounyan RE (1981) Bronchial hyperreactivity in response to inhalation of ultrasonically nebulised solutions of distilled water and saline. Br Med J 283:1285–1287

    Article  CAS  Google Scholar 

  46. Smith CM, Anderson SD (1986) Hyperosmolarity as the stimulus to asthma induced by hyperventilation? J Allergy Clin Immunol 77:729–736

    Article  PubMed  CAS  Google Scholar 

  47. Smith CM, Anderson SD (1990) Inhalational challenges using hypertonic saline in asthmatic subjects: a comparison with responses to hyperpnoea, methacholine and water. Eur Respir J 3:144–151

    PubMed  CAS  Google Scholar 

  48. Pizzichini E, Pizzichini MM, Efthimiadis A, Evans S, Morris MM, Squillace D, Gleich GJ, Dolovich J, Hargreave FE (1996) Indices of airway inflammation in induced sputum: repro-ducibility and validity of cell and fluid-phase measurements. Am J Respir Crit Care Med 154:308–317

    PubMed  CAS  Google Scholar 

  49. Iredale MJ, Wanklyn SA, Phillips IP, Krausz T, Ind PW (1994) Noninvasive assessment of bronchial inflammation in asthma: no correlation between eosinophilia of induced sputum and bronchial responsiveness to inhaled hypertonic saline. Clin Exp Allergy 24:940–945

    Article  PubMed  CAS  Google Scholar 

  50. Poloso R, Ng WH, Crimi N, Vancheri C, Holgate ST, Church MK, Mistretta A (1995) Release of mast-cell-derived mediators after endobronchial adenosine challenge in asthma. Am J Respir Crit Care Med 151:624–629

    Google Scholar 

  51. Anderson SD, Brannan J, Spring J, Spalding N, Rodwell LT, Chan K, Gonda I, Walsh A, Clark AR (1997) A new method for bronchial-provocation testing in asthmatic subjects using a dry powder of mannitol. Am J Respir Crit Care Med 156:758–765

    PubMed  CAS  Google Scholar 

  52. Brannan JD, Koskela H, Anderson SD, Chew N (1998) Responsiveness to mannitol in asthmatic subjects with exercise- and hyperventilation-induced asthma. Am J Respir Crit Care Med 158:1120–1126

    PubMed  CAS  Google Scholar 

  53. Holzer K, Anderson SD, Chan HK, Douglass J (2003) Mannitol as a challenge test to identify exercise-induced bronchoconstriction in elite athletes. Am J Respir Crit Care Med 167:534–537

    Article  PubMed  Google Scholar 

  54. Cartier A, Pineau L, Malo J-L (1984) Monitoring of maximum expiratory peak flow rates and histamine inhalation tests in the investigation of occupational asthma. Clin Allergy 14:193–196

    Article  PubMed  CAS  Google Scholar 

  55. Cartier A, L'Archeveque J, Malo J-L (1986) Exposure to a sensitizing occupational agent can cause a long-lasting increase in bronchial responsiveness to histamine in the absence of significant changes in airway caliber. J Allergy Clin Immunol 78:1185–1189

    Article  PubMed  CAS  Google Scholar 

  56. Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, Wardlaw AJ, Pavord ID (2002) Asthma exacerbations and sputum eosinophil counts: a randomized controlled trial. Lancet 360:1715–1721

    Article  PubMed  Google Scholar 

  57. Smith AD, Cowan JO, Brassett KP, Herbison GP, Taylor DR (2005) Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med 352:2163–2173

    Article  PubMed  CAS  Google Scholar 

  58. Sont JK, Willems LN, Bel EH, van Krieken JH, Vandenbroucke JP, Sterk PJ (1999) Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group. Am J Respir Crit Care Med 159:1043–1051

    CAS  Google Scholar 

  59. FitzGerald JM, Boulet LP, McIvor RA, Zimmerman S, Chapman KR (2006) Asthma control in Canada remains suboptimal: the Reality of Asthma Control (TRAC) study. Can Respir J 13:253–259

    PubMed  Google Scholar 

  60. van Lier l (1959) The influence of non-specific factors on the nasal mucous membrane in patients with rhinitis vasomotoria. Acta Allergol 13:507–509

    PubMed  Google Scholar 

  61. Litvyakova LI, Baraniuk JN (2001) Nasal provocation testing: a review. Ann Allergy Asthma Immunol 86:355–365

    Article  PubMed  CAS  Google Scholar 

  62. Melillo G, Bonini S, Cocco G, Davies RJ, de Monchy JG, Frolund L, Pelikan Z (1997) Provocation tests with allergens. Allergy 52(Suppl):5–36

    Article  Google Scholar 

  63. Holopainen E, Tarkiainen E, Malmberg H Nasal challenge (1976) Rhinology 14:181–188

    PubMed  CAS  Google Scholar 

  64. Lavasa S, Kumar L, Kaushal SC, Ganguli NK (1996) Wheat threshing dust-“new allergen” Indian Pediatr 33:566–570

    PubMed  CAS  Google Scholar 

  65. Baraniuk JN. Neuropeptides (1998) Am J Rhinol 12:9–16

    Article  PubMed  CAS  Google Scholar 

  66. Baraniuk JN, Lundgren JD, Mizoguchi H, Peden D, Gawin A, Merida M, Shelhamer JH, Kaliner MA (1990) Bradykinin respiratory mucous membranes. Analysis of bradykinin binding site distribution and secretory responses in vitro and in vivo. Am Rev Respir Dis 141:706–714

    PubMed  CAS  Google Scholar 

  67. Blom HM, Van Rijswijk JB. Garrelds IM, Mulder PG, Timmermans T, Gerth van Wijk R (1997) Intranasal capsaicin is efficacious in nonallergic, non-infectious perennial rhinitis. A placebo-controlled study. Clin Exp Allergy 796–801

    Google Scholar 

  68. Braat JP, Mulder PG, Fokkens WJ, van Wijk RG, Rijntjes E (1998) Intranasal cold dry air is superior to histamine challenge in determining the presence and degree of nasal hyper-reactivity in nonallergic noninfectious perennial rhinitis. Am J Respir Crit Care Med. 157:1748–1755

    PubMed  CAS  Google Scholar 

  69. Patriarca G, Nucera E, DiRienzo V, Schiavino D, Pellegrino S, Fais G (1991) Nasal provocation test with lysine acetylsalicylate in aspirin-sensitive patients. Ann Allergy 67:60–62

    PubMed  CAS  Google Scholar 

  70. Malm L, Gerth van Wijk R, Bachert C (2000) Guidelines for nasal provocations with aspects on nasal patency, airflow, and airflow resistance. International Committee on Objective Assessment of Nasal Airways, International Rhinologic Society. Rhinology 38:1–6

    PubMed  CAS  Google Scholar 

  71. Roithmann R, Chapnik J, Zamel N, Barreto SM, Cole P (1997) Acoustic rhinometric assessment of the nasal valve. Am J Rhinol 11:379–385

    Article  PubMed  CAS  Google Scholar 

  72. Taylor G, MacNeil AR, Freed DLJ (1973) Assessing degree of nasal patency by measuring peak expiratory flow rate through the nose. J Allergy Clin Immunol 52:193–198

    Article  PubMed  CAS  Google Scholar 

  73. Van Rijswijk JB, Boeke EL, Keizer JM, Mulder PG, Blom HM, Fokkens WJ (2003) Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: a double-blind randomized application regimen study. Allergy 58:754–761

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Division of Respirology, Critical Care and Sleep Medicine, Royal University Hospital/University of Saskatchewan, Saskatoon, SK, S7N 0W8, Canada

    John K. Reid, Donald W. Cockcroft & Beth E. Davis

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  1. John K. Reid
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  2. Donald W. Cockcroft
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  3. Beth E. Davis
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Editors and Affiliations

  1. Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan

    Ruby Pawankar

  2. Southampton General Hospital, University of Southampton, Tremona Road, Southampton, UK

    Stephen T. Holgate

  3. UMKC School of Medicine, Children's Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO, 64108, USA

    Lanny J. Rosenwasser

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Reid, J.K., Cockcroft, D.W., Davis, B.E. (2009). Nasal and Bronchial Nonallergic Provocation Tests. In: Pawankar, R., Holgate, S.T., Rosenwasser, L.J. (eds) Allergy Frontiers: Diagnosis and Health Economics. Allergy Frontiers, vol 4. Springer, Tokyo. https://doi.org/10.1007/978-4-431-98349-1_4

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  • DOI: https://doi.org/10.1007/978-4-431-98349-1_4

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