History of Allergy

  • Alan Edwards
Part of the Allergy Frontiers book series (ALLERGY, volume 4)

Allergy first defined by von Pirquet in 1906. Asthma and eczema first described by Hippocrates in 400BC. Other key events in history of allergy were identification of pollens as the cause of hay fever by Wyman and Blackley and that of the IgE antibody by the Ishizaka'a and Johansson.


Food Allergy Allergic Disease Grass Pollen Pollen Extract Systemic Mastocytosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    von Pirquet C (1906) Allergie. Munch Med Wochenschr 53:1457–158Google Scholar
  2. 2.
    C v Pirquet (1963) Appendix A. Allergy, (Translated from the German original by Carl Prausnitz) In Gell PGH, Coombs RRA (eds). Clinical aspects of immunology. Oxford: Blackwell ScientificGoogle Scholar
  3. 3.
    Portier P, Richet C (1902) De l'action anaphylactique de certains venins. C R Soc Biol (Paris) 54:170Google Scholar
  4. 4.
    Coombs RRA (1992) The Jack Pepys lecture. The hypersensitivity reactions — some personal reflections. Clin Exp Allergy 22:673–680PubMedCrossRefGoogle Scholar
  5. 5.
    Dunbar WP (1913) The present state of our knowledge of hay fever. J Hygiene 13:105CrossRefGoogle Scholar
  6. 6.
    Hide DW (1992) Carl Prausnitz — Father of clinical allergy. Southampton Med J 8(2)Google Scholar
  7. 7.
    Noon L (1911) Prophylactic inoculation against hay fever. Lancet 1:1572CrossRefGoogle Scholar
  8. 8.
    Freeman J (1930) “Rush” inoculation. Lancet 1:744CrossRefGoogle Scholar
  9. 9.
    Frankland AW, Augustin R (1954) Prophylaxis of summer hay fever and asthma: a controlled trial comparing crude grass-pollen extracts with the isolated main protein component. Lancet 1:1055–1057CrossRefGoogle Scholar
  10. 10.
    Curtis HH (1900) The immunizing cure of hay fever. Med News (NY) 77:16–18Google Scholar
  11. 11.
    Black JH (1927) The oral administration of pollen. J Lab Clin Med 12:1156Google Scholar
  12. 12.
    Prausnitz C, Kustner H (1921) Studien uber die uberempfindlichkeith. Zentralblatt fur Bakteriologie 86:160–169Google Scholar
  13. 13.
    Gell PGH, Coombs RRA (eds) (1963) Clinical aspects of immunology. Oxford: Blackwell ScientificGoogle Scholar
  14. 14.
    Coca AF, Grove EF (1925) Studies in hypersensitivness. J Immunol 10:445–464Google Scholar
  15. 15.
    Ishizaka K, Ishazaki T (1967) Identification of gamma-E antibodies as a carrier of reaginic activity. J Immunol 99:1187PubMedGoogle Scholar
  16. 16.
    Bennich H, Ishizaka K, Ishizaka T, Gunnar Johansson S (1969) A comparative antigenic study of λE-globulin and myeloma-IgND. J Immunol 102:826–831PubMedGoogle Scholar
  17. 17.
    Walzer M (1927) Studies in absorption of undigested proteins in human beings. J Immunol 14:143–174Google Scholar
  18. 18.
    Carini C, Brostoff J, Wraith DG (1987) IgE complexes in food allergy. Ann Allergy 59:110–117PubMedGoogle Scholar
  19. 19.
    Schultz WH (1909) Physiological studies in anaphylaxis. I. The reaction of smooth muscle of the guinea-pig sensitised with horse serum. J Pharmacol Exp Ther 1:566Google Scholar
  20. 20.
    Dale HH, Laidlaw PP (1911) The physiological action of β-iminazolylethylamine. J Physiol 41:318Google Scholar
  21. 21.
    Kellaway C, Trethwaite E (1940) The liberation of a slow reacting smooth muscle-stimulating substance in anaphylaxis. Q J Exp Physiol 30:121Google Scholar
  22. 22.
    Samuelsson, B (1983) Leukotrienes: mediators of immediate hypersensitivity reactions and inflammations. Science 220:568–575PubMedCrossRefGoogle Scholar
  23. 23.
    Riley J, West GB (1953) Histamine and tissue mast cells. J Physiol 120:528Google Scholar
  24. 24.
    Peipers A (1931) Ueber die Frage der Identität des hausstauballergens. Zeitschrift Immunitätsforch 71:359–364.Google Scholar
  25. 25.
    Lowell FC, Schiller IW (1947) Reduction in the vital capacity of asthmatic subjects following exposure to aerolised pollen extracts. Science 105:317PubMedCrossRefGoogle Scholar
  26. 26.
    Hargreave FE, Pepys J, Longbottom JL, Wraith DG (1966) Bird breeder's (Fancier's) lung. Lancet 1:445–449PubMedCrossRefGoogle Scholar
  27. 27.
    Pepys J, Hargreave FE, Chan M, McCarthy DS (1968) Inhibitory effects of disodium cromo-glycate on allergen-inhalation tests. Lancet 2:134–137PubMedCrossRefGoogle Scholar
  28. 28.
    Booij-Noord H, Orie NGM, de vries K (1971) Immediate and late bronchial obstructive reactions to inhalation of house dust and protective effects of disodium cromoglycate and prednisolone. J Allergy Clin Immunol 48(6):344–354PubMedCrossRefGoogle Scholar
  29. 29.
    Edwards AM, Howell JBL (2000) The chromones: history, chemistry and clinical development: a tribute to the work of REC. Altounyan Clin Exp Allergy 30:756–774CrossRefGoogle Scholar
  30. 30.
    Law M, Morris JK, Wald N, Luczynska C, Burney P (2005) Changes in atopy over a quarter of a century, based on cross sectional data at three time periods. BMJ 330:1187–1188.PubMedCrossRefGoogle Scholar
  31. 31.
    Silverstein AM (2000) Clemens Freiherr von Pirquet: Explaining immune complex disease in 1906. Nature Immunol 1:453–455CrossRefGoogle Scholar
  32. 32.
    Blackley CH (1873) Experimental Researches on the Nature and Causes of Catarrhus Aestivus. London: Balliere Tindall & CoxGoogle Scholar

Copyright information

© Springer 2009

Authors and Affiliations

  • Alan Edwards
    • 1
  1. 1.The David Hide Asthma and Allergy Research CentreNewportUK

Personalised recommendations