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Hypoxia Imaging for Image-Guided Radiotherapy

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Molecular Imaging for Integrated Medical Therapy and Drug Development

Abstract

Tumor hypoxia, or the condition of low oxygen, is a key factor for tumor progression and treatment resistance. Because hypoxic tumor cells are more resistant to ionizing radiation, hypoxia has been a focus of clinical research in radiation therapy for half a century. During this period, interest in targeting tumor hypoxia has waxed and waned as promising treatments emerged from the laboratory, only to fail in the clinics. With the development of new radiation targeting strategies, specifically intensity-modulated radiotherapy (IMRT) and image guidance technologies (image-guided RT; IGRT), there is a strong interest in imaging hypoxia for radiation targeting and dose escalation. In this review, we will discuss the role of hypoxia imaging, specifically positron emission tomography (PET)-based imaging with hypoxia-specific tracers, for directing radiation treatment in solid tumors.

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Stanford University, 875 Blake Wilbur Dr, MC 5847, Stanford, CA, 94305-5847, USA

    Quynh-Thu Le & Billy W. Loo

  2. Memorial Sloan Kettering Cancer Center, 1275 York Ave, NY, 10021, USA

    Nancy Lee

Authors
  1. Quynh-Thu Le
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  2. Billy W. Loo
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  3. Nancy Lee
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Editors and Affiliations

  1. Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-8638, Japan

    Nagara Tamaki M.D., Ph.D.

  2. Department of Tracer Kinetics and Bioanalysis, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-8638, Japan

    Yuji Kuge Ph.D.

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© 2010 Springer

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Le, QT., Loo, B.W., Lee, N. (2010). Hypoxia Imaging for Image-Guided Radiotherapy. In: Tamaki, N., Kuge, Y. (eds) Molecular Imaging for Integrated Medical Therapy and Drug Development. Springer, Tokyo. https://doi.org/10.1007/978-4-431-98074-2_2

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  • DOI: https://doi.org/10.1007/978-4-431-98074-2_2

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-98073-5

  • Online ISBN: 978-4-431-98074-2

  • eBook Packages: MedicineMedicine (R0)

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