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Medaka pp 59-77 | Cite as

A Systematic Screen for Mutations Affecting Organogenesis in Medaka

  • Makoto Furutani-Seiki

Abstract

The use of a single species for mutagenesis screening will not be sufficient to uncover all gene functions because of functional overlap of related genes in vertebrates. Medaka fish with accumulated knowledge and expertise in genetics and biology were successfully adopted for a systematic screen for mutations affecting organogenesis. Despite exhaustive screens in zebrafish, a large number of mutants with new distinct phenotypes were identified in the large-scale medaka screen, indicating that by carrying out screens in both species more mutants and/or phenotypes can be found and that screens in medaka and zebrafish are complementary. Straightforward comparison of phenotypes, ease of side-by-side analysis using the same techniques, and ease of raising the mutants of medaka and zebrafish in an aquarium, together with their draft genome sequences, facilitate further genetic dissection. Thus, the two fish models will provide essential supplements to finding the most difficult targets in mammalian mutant screens, mutants that become lethal in the uterus during development. Analyses of mutants of these three vertebrate models neatly complement each other and will lead to elucidation of the global functions of the vertebrate genome.

Keywords

Germ Cell Bacterial Artificial Chromosome Pharyngeal Arch Otic Vesicle Systematic Screen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ENU

N-Ethyl N-nitrosourea

TILLING

Targeting induced local lesions in genomes

Notes

Acknowledgments

I am grateful to all the colleagues who contributed to the Kyoto medaka screen and to Dr. Robert Kelsh and Prof. Cheryll Tickle for critically reading the manuscript. The Kyoto medaka screen was carried out in the ERATO/SORST project directed by Prof. Hisato Kondoh and was generously supported by the grant of the Japan Science and Technology Agency (JST).

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© Springer 2011

Authors and Affiliations

  1. 1.Centre for Regenerative Medicine, Department of Biology and BiochemistryThe University of BathBathUK

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