Medaka harbors active DNA-based transposable elements in its genome. This feature is unique among vertebrates and has enabled a wide range of studies on DNA-based elements, specifically on such topics as their transposition mechanisms, their population dynamics, and their contribution to genome evolution as natural mutagens. Findings of particular significance include the rapid expansion of an element in the medaka genome, the elevation of the mutation rate of host genes, and the disappearance of elements after they have functioned as mutagens. In addition to these contributions to basic biology, active DNA-based elements from medaka have also contributed to the development of tools for genetic manipulations, such as gene transfer, mutagenesis, gene tagging, and promoter/enhancer trapping. These tools are now used in a wide range of vertebrates, including humans, mice, and zebrafish.
KeywordsTransposable Element Target Site Duplication Transposase Gene Tyrosinase Gene Albino Mutant
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