Medaka pp 255-267 | Cite as

The Sex-Determining Gene in Medaka


Because the sex of most vertebrate species is determined by genetic information, these species must possess a sex-determining gene in their genome. The first sex-determining gene among vertebrates was identified in mammals. Thereafter, for more than a decade, no other sex-determining gene was found. The second sex-determining gene in vertebrates was identified in medaka (Oryzias latipes). This gene is designated Dmy or DMRT1bY and has a DNA-binding motif that is different from that of the mammalian sex-determining gene SRY or Sry. In this review, I have focused on the isolation of the sex-determining gene of medaka. The identification of the sex-determining gene has revealed the diversity among the sex chromosomes of medaka. This knowledge has provided important clues that are useful to study the diversity of sex-determining genes in vertebrates and to identify the sex-determining genes in other nonmammalian vertebrates.


Germ Cell Nonmammalian Vertebrate Gonadal Somatic Cell Medaka Male 
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© Springer 2011

Authors and Affiliations

  1. 1.Center for Bioscience Research & EducationUtsunomiya UniversityUtsunomiyaJapan

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